Lack of effect of ECN on sensorimotor tests in ob/ob and wild-type mice. Panels show histograms of average time in seconds in different sensorimotor tests such as inclined plane
(A), platform (B), and ledge (C) for wild-type (open bars) and ob/ob mice (filled bars). Baseline measurements were taken 2 days before (B), immediately before (0 min), and 90–120 min after ECN injection (25 mg/kg i.p.). Vertical bars indicate SE of multiple determinations.
We used two-way ANOVA followed by pairwise comparison to analyze results, finding that ECN had no significant effect on either
test, because P > 0.05 in comparisons of time points within each animal group (n = 5 mice in each group). WT, wild type.