SIRT1 Genetic Variation Is Related to BMI and Risk of Obesity

TABLE 2

BMI in the Rotterdam Study and the ERF study by SIRT1 genotype and longitudinal BMI change in the Rotterdam Study

Genotype Rotterdam Study baseline
Rotterdam Study follow-up
Rotterdam Study BMI change
ERF study
P combined
MAF* Effect size per allele copy P trend MAF Effect size per allele copy P trend MAF Effect size per allele copy P trend MAF Effect size per allele copy P trend
rs7895833 0.20 −0.190 (0.08) 0.02 0.20 −0.291 (0.12) 0.02 0.20 −0.126 (0.05) 0.01 0.23 −0.350 (0.16) 0.03 0.002
rs1467568 0.37 −0.149 (0.07) 0.04 0.37 −0.238 (0.10) 0.02 0.37 −0.075 (0.04) 0.08 0.41 −0.372 (0.14) 0.008 0.002
rs497849 0.22 +0.030 (0.08) 0.70 0.22 −0.054 (0.11) 0.62 0.22 −0.020 (0.05) 0.69
Haplotype 1 0.41 +0.130 (0.07) 0.07 0.41 +0.273 (0.10) 0.008 0.41 +0.070 (0.05) 0.11
  • Analyses adjusted for age, sex, and genomic control and, in ERF, also for family structure.

  • *Minor allele rs7895833; G, rs1467568; A, rs497849.

  • †Effect size is difference in BMI (kg/m2) (SE) or difference in BMI change per allele.

  • P combined analysis for Rotterdam Study baseline and the ERF study. MAF, minor allele frequency.

This Article

  1. Diabetes vol. 58 no. 12 2828-2834