SIRT1 Genetic Variation Is Related to BMI and Risk of Obesity

TABLE 3

Risk of being overweight (A) or obese (B) in the Rotterdam Study at baseline, the ERF study, and studies combined by SIRT1 genotype

Genotype n case/control subjects OR (95% CI) P value dominant model P value additive model P value recessive model Genotype n case/control subjects OR (95% CI) P value dominant model P value additive model P value recessive model
A: Overweight (BMI >25 kg/m2) rs7895833 rs1467568
    Rotterdam Study AA 2,389/1,390 1 (reference) GG 1,497/863 1 (reference)
AG + GG 1,311/869 0.88 (0.79–0.99) 0.03 0.03 0.42 GA + AA 2,207/1,398 0.91 (0.82–1.02) 0.09 0.27 0.85
    ERF study AA 854/487 1 (reference) GG 509/259 1 (reference)
AG + GG 559/359 0.95 (0.84–1.06) 0.35 0.08 0.01 GA + AA 910/593 0.88 (0.84–0.91) 0.02 1.9 × 10−6 0.02
    Studies combined 0.91 (0.84–0.99) 0.02 0.006 0.02 0.89 (0.83–0.97) 0.005 3.5 × 10−6 0.06
B: Obese (BMI >30 kg/m2) rs7895833 rs1467568
    Rotterdam Study AA 577/1,390 1 (reference) GG 377/863 1 (reference)
AG + GG 282/869 0.79 (0.67–0.94) 0.007 0.008 0.20 GA + AA 483/1,398 0.80 (0.68–0.94) 0.007 0.01 0.34
    ERF study AA 276/487 1 (reference) GG 164/259 1 (reference)
AG + GG 161/359 0.93 (0.73–1.19) 0.37 0.23 0.25 GA + AA 277/593 0.85 (0.72–0.99) 0.04 0.05 0.35
    Studies combined 0.87 (0.77–0.97) 0.02 0.009 0.10 0.82 (0.73–0.92) 0.0009 0.002 0.20
  • Analyses adjusted for age, sex, and genomic control and, in the ERF study, also for family structure. BMI of control subjects 18.5–25 kg/m2.

This Article

  1. Diabetes vol. 58 no. 12 2828-2834