Location of Arterial Stiffening Differs in Those With Impaired Fasting Glucose Versus Diabetes
Implications for Left Ventricular Hypertrophy From the Multi-Ethnic Study of Atherosclerosis
- Pairoj Rerkpattanapipat1,
- Ralph B. D'Agostino, Jr1,
- Kerry M. Link2,
- Eyal Shahar3,
- Joao A. Lima4,
- David A. Bluemke5,
- Shantanu Sinha6,
- David M. Herrington7,8 and
- W. Gregory Hundley1,7
- 1Department of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina;
- 2Department of Radiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina; and
- 3Division of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona;
- 4D. W. Reynolds Cardiovascular Research Center, Johns Hopkins, Baltimore, Maryland;
- 5Russell H. Morgan Department of Radiology & Radiological Sciences, Johns Hopkins, Baltimore, Maryland;
- 6Department of Radiology, University of California at San Diego, San Diego, California;
- 7Department of Internal Medicine (Cardiology Section), Wake Forest University School of Medicine, Winston-Salem, North Carolina;
- 8Department of Biomedical Engineering, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
- Corresponding author: W. Gregory Hundley, ghundley{at}wfubmc.edu.
Abstract
OBJECTIVE To determine whether middle-aged and older individuals with impaired fasting glucose (IFG), but no clinical evidence of cardiovascular disease, exhibit abnormal changes in proximal thoracic aortic stiffness or left ventricular (LV) mass when compared with healthy counterparts.
RESEARCH DESIGN AND METHODS From the Multi-Ethnic Study of Atherosclerosis, 2,240 subjects with normal fasting glucose (NFG), 845 with IFG, and 414 with diabetes, all aged 45 to 85 years and without preexisting coronary artery disease, underwent MRI determinations of total arterial and proximal thoracic aortic stiffness and LV mass. The presence or absence of other factors known to influence arterial stiffness was assessed.
RESULTS After adjustment for clinical factors known to modify arterial stiffness, proximal thoracic aortic stiffness was not increased in those with IFG compared with those with NFG (1.90 ± 0.05 versus 1.91 ± 0.04 10−3 mmHg−1, respectively, P = 0.83). After accounting for clinical factors known to influence LV mass, LV mass was increased in those with diabetes relative to those with NFG (150.6 ± 1.4 versus 145.8 ± 0.81 g, P < 0.0009) but not in those with IFG in comparison with NFG (145.2 ± 1.03 versus 145.8 ± 0.81 g, P = 0.56).
CONCLUSIONS Middle-aged and older individuals with the pre-diabetes state of IFG do not exhibit abnormal proximal thoracic distensibility or LV hypertrophy relative to individuals with NFG. For this reason, an opportunity may exist in those with IFG to prevent LV hypertrophy and abnormal aortic stiffness that is observed in middle-aged and older individuals with diabetes.
Footnotes
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The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
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- Received August 28, 2008.
- Accepted January 2, 2009.
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Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
- © 2009 by the American Diabetes Association.
