Comment on: Reyna et al. (2008) Elevated Toll-Like Receptor 4 Expression and Signaling in Muscle From Insulin-Resistant Subjects. Diabetes 57:2595–2602
- Haim Shapiro1,
- Pierre Singer2,3 and
- Joelle Attal-Singer3,4
- 1Institute for Nutrition Research, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel
- 2Department of General Intensive Care, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel;
- 3Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; and
- 4Institute of Endocrinology, Diabetes Services, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel.
- Corresponding author: Haim Shapiro, haim_shapiro{at}yahoo.com.
We read with interest an important finding by Reyna et al. (1) that the toll-like receptor (TLR)4→nuclear factor κB (NFκB) pathway is overstimulated in the skeletal muscle of patients with type 2 diabetes and that this may be secondary to free saturated fatty acid (FSFA) activation of TLR4. We would like the investigators' opinion on how their data should be interpreted in light of previous data …
