Table of Contents

Online Letter to the Editor

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- Yafang Hu,
- Takuya Nishimura,
- Aiping Zhang,
- and Abner L. Notkins
Comment on: Torii et al. (2009) Gene Silencing of Phogrin Unveils Its Essential Role in Glucose-Responsive Pancreatic β-Cell Growth. Diabetes 58:682–692
Diabetes May 2009 58:e8; doi:10.2337/db09-0168

Commentary

Commentaries

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- Thierry Alquier and
- Vincent Poitout
GPR40: Good Cop, Bad Cop?
Diabetes May 2009 58:1035-1036; doi:10.2337/db09-0215
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- Abdul G. Dulloo
Adipose Tissue Plasticity in Catch-Up–Growth Trajectories to Metabolic Syndrome: Hyperplastic Versus Hypertrophic Catch-Up Fat
Diabetes May 2009 58:1037-1039; doi:10.2337/db09-0290

Original Article

Metabolism

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- Prachiti Narvekar,
- Mauricio Berriel Diaz,
- Anja Krones-Herzig,
- Ulrike Hardeland,
- Daniela Strzoda,
- Sigrid Stöhr,
- Marcus Frohme,
- and Stephan Herzig
Liver-Specific Loss of Lipolysis-Stimulated Lipoprotein Receptor Triggers Systemic Hyperlipidemia in Mice
Diabetes May 2009 58:1040-1049; published ahead of print February 2, 2009, doi:10.2337/db08-1184
Select this article
- Huangming Xie,
- Bing Lim,
- and Harvey F. Lodish
MicroRNAs Induced During Adipogenesis that Accelerate Fat Cell Development Are Downregulated in Obesity
Diabetes May 2009 58:1050-1057; published ahead of print February 2, 2009, doi:10.2337/db08-1299
Select this article
- Lina M. Lauffer,
- Roman Iakoubov,
- and Patricia L. Brubaker
GPR119 Is Essential for Oleoylethanolamide-Induced Glucagon-Like Peptide-1 Secretion From the Intestinal Enteroendocrine L-Cell
Diabetes May 2009 58:1058-1066; published ahead of print February 10, 2009, doi:10.2337/db08-1237
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- Kae Nagasumi,
- Ritsuko Esaki,
- Kimihiko Iwachidow,
- Yoshitaka Yasuhara,
- Kazuhiro Ogi,
- Hideyuki Tanaka,
- Mitsugu Nakata,
- Takashi Yano,
- Kozo Shimakawa,
- Shigehisa Taketomi,
- Koji Takeuchi,
- Hiroyuki Odaka,
- and Yoshihiko Kaisho
Overexpression of GPR40 in Pancreatic β-Cells Augments Glucose-Stimulated Insulin Secretion and Improves Glucose Tolerance in Normal and Diabetic Mice
Diabetes May 2009 58:1067-1076; doi:10.2337/db08-1233

Signal Transduction

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- Ke-Ping Xu,
- Yanfeng Li,
- Alexander V. Ljubimov,
- and Fu-Shin X. Yu
High Glucose Suppresses Epidermal Growth Factor Receptor/Phosphatidylinositol 3-Kinase/Akt Signaling Pathway and Attenuates Corneal Epithelial Wound Healing
Diabetes May 2009 58:1077-1085; published ahead of print February 2, 2009, doi:10.2337/db08-0997
Select this article
- Derek Y.C. Yuen,
- Renee M. Dwyer,
- Vance B. Matthews,
- Lei Zhang,
- Brian G. Drew,
- Bronwyn Neill,
- Bronwyn A. Kingwell,
- Michael G. Clark,
- Stephen Rattigan,
- and Mark A. Febbraio
Interleukin-6 Attenuates Insulin-Mediated Increases in Endothelial Cell Signaling but Augments Skeletal Muscle Insulin Action via Differential Effects on Tumor Necrosis Factor-α Expression
Diabetes May 2009 58:1086-1095; published ahead of print February 2, 2009, doi:10.2337/db08-0775
Select this article
- Katsuhiko Funai and
- Gregory D. Cartee
Inhibition of Contraction-Stimulated AMP-Activated Protein Kinase Inhibits Contraction-Stimulated Increases in PAS-TBC1D1 and Glucose Transport Without Altering PAS-AS160 in Rat Skeletal Muscle
Diabetes May 2009 58:1096-1104; published ahead of print February 10, 2009, doi:10.2337/db08-1477
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- Safia Costes,
- Brigitte Vandewalle,
- Cécile Tourrel-Cuzin,
- Christophe Broca,
- Nathalie Linck,
- Gyslaine Bertrand,
- Julie Kerr-Conte,
- Bernard Portha,
- François Pattou,
- Joel Bockaert,
- and Stéphane Dalle
Degradation of cAMP-Responsive Element–Binding Protein by the Ubiquitin-Proteasome Pathway Contributes to Glucotoxicity in β-Cells and Human Pancreatic Islets
Diabetes May 2009 58:1105-1115; published ahead of print February 17, 2009, doi:10.2337/db08-0926

Obesity Studies

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- Kellie L.K. Tamashiro,
- Chantelle E. Terrillion,
- Jayson Hyun,
- James I. Koenig,
- and Timothy H. Moran
Prenatal Stress or High-Fat Diet Increases Susceptibility to Diet-Induced Obesity in Rat Offspring
Diabetes May 2009 58:1116-1125; published ahead of print February 2, 2009, doi:10.2337/db08-1129
Select this article
- Nora E. Straznicky,
- Gavin W. Lambert,
- Mariee T. McGrane,
- Kazuko Masuo,
- Tye Dawood,
- Paul J. Nestel,
- Nina Eikelis,
- Markus P. Schlaich,
- Murray D. Esler,
- Florentia Socratous,
- Reena Chopra,
- and Elisabeth A. Lambert
Weight Loss May Reverse Blunted Sympathetic Neural Responsiveness to Glucose Ingestion in Obese Subjects With Metabolic Syndrome
Diabetes May 2009 58:1126-1132; published ahead of print February 2, 2009, doi:10.2337/db08-1595
Select this article
- Jason J. Wilkes,
- David J. Lloyd,
- and Nick Gekakis
Loss-of-Function Mutation in Myostatin Reduces Tumor Necrosis Factor α Production and Protects Liver Against Obesity-Induced Insulin Resistance
Diabetes May 2009 58:1133-1143; published ahead of print February 10, 2009, doi:10.2337/db08-0245

Immunology and Transplantation

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- Andrew P.R. Sutherland,
- Tom Van Belle,
- Andrea L. Wurster,
- Akira Suto,
- Monia Michaud,
- Dorothy Zhang,
- Michael J. Grusby,
- and Matthias von Herrath
Interleukin-21 Is Required for the Development of Type 1 Diabetes in NOD Mice
Diabetes May 2009 58:1144-1155; published ahead of print February 10, 2009, doi:10.2337/db08-0882
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- F. Susan Wong,
- Lai Khai Siew,
- Gwen Scott,
- Ian J. Thomas,
- Stephen Chapman,
- Christophe Viret,
- and Li Wen
Activation of Insulin-Reactive CD8 T-Cells for Development of Autoimmune Diabetes
Diabetes May 2009 58:1156-1164; published ahead of print February 10, 2009, doi:10.2337/db08-0800

Islet Studies

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- Eunjin Oh and
- Debbie C. Thurmond
Munc18c Depletion Selectively Impairs the Sustained Phase of Insulin Release
Diabetes May 2009 58:1165-1174; published ahead of print February 2, 2009, doi:10.2337/db08-1059
Select this article
- Klaus Pechhold,
- Xiaolong Zhu,
- Victor S. Harrison,
- Janet Lee,
- Sagarika Chakrabarty,
- Kerstin Koczwara,
- Oksana Gavrilova,
- and David M. Harlan
Dynamic Changes in Pancreatic Endocrine Cell Abundance, Distribution, and Function in Antigen-Induced and Spontaneous Autoimmune Diabetes
Diabetes May 2009 58:1175-1184; published ahead of print February 19, 2009, doi:10.2337/db08-0616

Pathophysiology

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- Geraldine F. Clough,
- Magdalena Turzyniecka,
- Lara Walter,
- Andrew J. Krentz,
- Sarah H. Wild,
- Andrew J. Chipperfield,
- John Gamble,
- and Christopher D. Byrne
Muscle Microvascular Dysfunction in Central Obesity Is Related to Muscle Insulin Insensitivity but Is Not Reversed by High-Dose Statin Treatment
Diabetes May 2009 58:1185-1191; published ahead of print February 10, 2009, doi:10.2337/db08-1688
Select this article
- Elvira Isganaitis,
- Jose Jimenez-Chillaron,
- Melissa Woo,
- Alice Chow,
- Jennifer DeCoste,
- Martha Vokes,
- Manway Liu,
- Simon Kasif,
- Ann-Marie Zavacki,
- Rebecca L. Leshan,
- Martin G. Myers,
- and Mary-Elizabeth Patti
Accelerated Postnatal Growth Increases Lipogenic Gene Expression and Adipocyte Size in Low–Birth Weight Mice
Diabetes May 2009 58:1192-1200; published ahead of print February 10, 2009, doi:10.2337/db08-1266
Select this article
- Assaad A. Eid,
- Yves Gorin,
- Bridget M. Fagg,
- Rita Maalouf,
- Jeffrey L. Barnes,
- Karen Block,
- and Hanna E. Abboud
Mechanisms of Podocyte Injury in Diabetes: Role of Cytochrome P450 and NADPH Oxidases
Diabetes May 2009 58:1201-1211; published ahead of print February 10, 2009, doi:10.2337/db08-1536
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- Alena Stančáková,
- Martin Javorský,
- Teemu Kuulasmaa,
- Steven M. Haffner,
- Johanna Kuusisto,
- and Markku Laakso
Changes in Insulin Sensitivity and Insulin Release in Relation to Glycemia and Glucose Tolerance in 6,414 Finnish Men
Diabetes May 2009 58:1212-1221; published ahead of print February 17, 2009, doi:10.2337/db08-1607

Complications

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- Pauline A.M. Roest,
- Daniël G.M. Molin,
- Casper G. Schalkwijk,
- Liesbeth van Iperen,
- Parri Wentzel,
- Ulf J. Eriksson,
- and Adriana C. Gittenberger-de Groot
Specific Local Cardiovascular Changes of N^ɛ-(Carboxymethyl)lysine, Vascular Endothelial Growth Factor, and Smad2 in the Developing Embryos Coincide With Maternal Diabetes–Induced Congenital Heart Defects
Diabetes May 2009 58:1222-1228; published ahead of print February 2, 2009, doi:10.2337/db07-1016
Select this article
- Daniella Brasacchio,
- Jun Okabe,
- Christos Tikellis,
- Aneta Balcerczyk,
- Prince George,
- Emma K. Baker,
- Anna C. Calkin,
- Michael Brownlee,
- Mark E. Cooper,
- and Assam El-Osta
Hyperglycemia Induces a Dynamic Cooperativity of Histone Methylase and Demethylase Enzymes Associated With Gene-Activating Epigenetic Marks That Coexist on the Lysine Tail
Diabetes May 2009 58:1229-1236; published ahead of print February 10, 2009, doi:10.2337/db08-1666
Select this article
- Kathleen A. Page,
- Anne Williamson,
- Namyi Yu,
- Ewan C. McNay,
- James Dzuira,
- Rory J. McCrimmon,
- and Robert S. Sherwin
Medium-Chain Fatty Acids Improve Cognitive Function in Intensively Treated Type 1 Diabetic Patients and Support In Vitro Synaptic Transmission During Acute Hypoglycemia
Diabetes May 2009 58:1237-1244; published ahead of print February 17, 2009, doi:10.2337/db08-1557

Genetics

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- Sylvia F. Boj,
- Joan Marc Servitja,
- David Martin,
- Martin Rios,
- Iannis Talianidis,
- Roderic Guigo,
- and Jorge Ferrer
Functional Targets of the Monogenic Diabetes Transcription Factors HNF-1α and HNF-4α Are Highly Conserved Between Mice and Humans
Diabetes May 2009 58:1245-1253; published ahead of print February 2, 2009, doi:10.2337/db08-0812

Diabetes

Online Letter to the Editor

Comment on: Torii et al. (2009) Gene Silencing of Phogrin Unveils Its Essential Role in Glucose-Responsive Pancreatic β-Cell Growth. Diabetes 58:682–692

Commentary

Commentaries

GPR40: Good Cop, Bad Cop?

Adipose Tissue Plasticity in Catch-Up–Growth Trajectories to Metabolic Syndrome: Hyperplastic Versus Hypertrophic Catch-Up Fat

Original Article

Metabolism

Liver-Specific Loss of Lipolysis-Stimulated Lipoprotein Receptor Triggers Systemic Hyperlipidemia in Mice

MicroRNAs Induced During Adipogenesis that Accelerate Fat Cell Development Are Downregulated in Obesity

GPR119 Is Essential for Oleoylethanolamide-Induced Glucagon-Like Peptide-1 Secretion From the Intestinal Enteroendocrine L-Cell

Overexpression of GPR40 in Pancreatic β-Cells Augments Glucose-Stimulated Insulin Secretion and Improves Glucose Tolerance in Normal and Diabetic Mice

Signal Transduction

High Glucose Suppresses Epidermal Growth Factor Receptor/Phosphatidylinositol 3-Kinase/Akt Signaling Pathway and Attenuates Corneal Epithelial Wound Healing

Interleukin-6 Attenuates Insulin-Mediated Increases in Endothelial Cell Signaling but Augments Skeletal Muscle Insulin Action via Differential Effects on Tumor Necrosis Factor-α Expression

Inhibition of Contraction-Stimulated AMP-Activated Protein Kinase Inhibits Contraction-Stimulated Increases in PAS-TBC1D1 and Glucose Transport Without Altering PAS-AS160 in Rat Skeletal Muscle

Degradation of cAMP-Responsive Element–Binding Protein by the Ubiquitin-Proteasome Pathway Contributes to Glucotoxicity in β-Cells and Human Pancreatic Islets

Obesity Studies

Prenatal Stress or High-Fat Diet Increases Susceptibility to Diet-Induced Obesity in Rat Offspring

Weight Loss May Reverse Blunted Sympathetic Neural Responsiveness to Glucose Ingestion in Obese Subjects With Metabolic Syndrome

Loss-of-Function Mutation in Myostatin Reduces Tumor Necrosis Factor α Production and Protects Liver Against Obesity-Induced Insulin Resistance

Immunology and Transplantation

Interleukin-21 Is Required for the Development of Type 1 Diabetes in NOD Mice

Activation of Insulin-Reactive CD8 T-Cells for Development of Autoimmune Diabetes

Islet Studies

Munc18c Depletion Selectively Impairs the Sustained Phase of Insulin Release

Dynamic Changes in Pancreatic Endocrine Cell Abundance, Distribution, and Function in Antigen-Induced and Spontaneous Autoimmune Diabetes

Pathophysiology

Muscle Microvascular Dysfunction in Central Obesity Is Related to Muscle Insulin Insensitivity but Is Not Reversed by High-Dose Statin Treatment

Accelerated Postnatal Growth Increases Lipogenic Gene Expression and Adipocyte Size in Low–Birth Weight Mice

Mechanisms of Podocyte Injury in Diabetes: Role of Cytochrome P450 and NADPH Oxidases

Changes in Insulin Sensitivity and Insulin Release in Relation to Glycemia and Glucose Tolerance in 6,414 Finnish Men

Complications

Specific Local Cardiovascular Changes of Nɛ-(Carboxymethyl)lysine, Vascular Endothelial Growth Factor, and Smad2 in the Developing Embryos Coincide With Maternal Diabetes–Induced Congenital Heart Defects

Hyperglycemia Induces a Dynamic Cooperativity of Histone Methylase and Demethylase Enzymes Associated With Gene-Activating Epigenetic Marks That Coexist on the Lysine Tail

Medium-Chain Fatty Acids Improve Cognitive Function in Intensively Treated Type 1 Diabetic Patients and Support In Vitro Synaptic Transmission During Acute Hypoglycemia

Genetics

Functional Targets of the Monogenic Diabetes Transcription Factors HNF-1α and HNF-4α Are Highly Conserved Between Mice and Humans

This Issue

Current Issue

Specific Local Cardiovascular Changes of N^ɛ-(Carboxymethyl)lysine, Vascular Endothelial Growth Factor, and Smad2 in the Developing Embryos Coincide With Maternal Diabetes–Induced Congenital Heart Defects