Table of Contents

June 2009; 58 (6)

Commentary

Commentaries

    • Juris J. Meier

    Linking the Genetics of Type 2 Diabetes With Low Birth Weight: A Role for Prenatal Islet Maldevelopment?

    Diabetes June 2009 58:1255-1256; doi:10.2337/db09-0225
    • Peter In't Veld

    Insulitis in Type 1 Diabetes: A Sticky Problem

    Diabetes June 2009 58:1257-1258; doi:10.2337/db09-0345

Original Article

Metabolism

    • Karly C. Sourris,
    • Jasmine G. Lyons,
    • Maximilian P.J. de Courten,
    • Sonia L. Dougherty,
    • Darren C. Henstridge,
    • Mark E. Cooper,
    • Michelle Hage,
    • Anthony Dart,
    • Bronwyn A. Kingwell,
    • Josephine M. Forbes,
    • and Barbora de Courten

    c-Jun NH2-Terminal Kinase Activity in Subcutaneous Adipose Tissue but Not Nuclear Factor-κB Activity in Peripheral Blood Mononuclear Cells Is an Independent Determinant of Insulin Resistance in Healthy Individuals

    Diabetes June 2009 58:1259-1265; published ahead of print March 3, 2009, doi:10.2337/db08-1725
    • Lihong Jiang,
    • Raimund I. Herzog,
    • Graeme F. Mason,
    • Robin A. de Graaf,
    • Douglas L. Rothman,
    • Robert S. Sherwin,
    • and Kevin L. Behar

    Recurrent Antecedent Hypoglycemia Alters Neuronal Oxidative Metabolism In Vivo

    Diabetes June 2009 58:1266-1274; published ahead of print March 10, 2009, doi:10.2337/db08-1664
    • Jane J. Kim,
    • Pingping Li,
    • Jessica Huntley,
    • Jeffrey P. Chang,
    • Karen C. Arden,
    • and Jerrold M. Olefsky

    FoxO1 Haploinsufficiency Protects Against High-Fat Diet–Induced Insulin Resistance With Enhanced Peroxisome Proliferator–Activated Receptor γ Activation in Adipose Tissue

    Diabetes June 2009 58:1275-1282; published ahead of print March 16, 2009, doi:10.2337/db08-1001

Signal Transduction

    • Fabrice Moore,
    • Maikel L. Colli,
    • Miriam Cnop,
    • Mariana Igoillo Esteve,
    • Alessandra K. Cardozo,
    • Daniel A. Cunha,
    • Marco Bugliani,
    • Piero Marchetti,
    • and Décio L. Eizirik

    PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon-γ–Induced Pancreatic β-Cell Apoptosis

    Diabetes June 2009 58:1283-1291; published ahead of print March 31, 2009, doi:10.2337/db08-1510

Immunology and Transplantation

    • John D. Glawe,
    • D. Ross Patrick,
    • Meng Huang,
    • Christopher D. Sharp,
    • Shayne C. Barlow,
    • and Christopher G. Kevil

    Genetic Deficiency of Itgb2 or ItgaL Prevents Autoimmune Diabetes Through Distinctly Different Mechanisms in NOD/LtJ Mice

    Diabetes June 2009 58:1292-1301; published ahead of print February 17, 2009, doi:10.2337/db08-0804
    • Juliet A. Emamaullee,
    • Joy Davis,
    • Shaheed Merani,
    • Christian Toso,
    • John F. Elliott,
    • Aducio Thiesen,
    • and A.M. James Shapiro

    Inhibition of Th17 Cells Regulates Autoimmune Diabetes in NOD Mice

    Diabetes June 2009 58:1302-1311; published ahead of print March 16, 2009, doi:10.2337/db08-1113

Islet Studies

    • Shuen-Ing Tschen,
    • Sangeeta Dhawan,
    • Tatyana Gurlo,
    • and Anil Bhushan

    Age-Dependent Decline in β-Cell Proliferation Restricts the Capacity of β-Cell Regeneration in Mice

    Diabetes June 2009 58:1312-1320; published ahead of print February 19, 2009, doi:10.2337/db08-1651
    • Suirin Hamada,
    • Kenta Hara,
    • Takeshi Hamada,
    • Hisafumi Yasuda,
    • Hiroaki Moriyama,
    • Rika Nakayama,
    • Masao Nagata,
    • and Koichi Yokono

    Upregulation of the Mammalian Target of Rapamycin Complex 1 Pathway by Ras Homolog Enriched in Brain in Pancreatic β-Cells Leads to Increased β-Cell Mass and Prevention of Hyperglycemia

    Diabetes June 2009 58:1321-1332; published ahead of print March 3, 2009, doi:10.2337/db08-0519

Pathophysiology

    • Gertrud Kacerovsky-Bielesz,
    • Marek Chmelik,
    • Charlotte Ling,
    • Rochus Pokan,
    • Julia Szendroedi,
    • Michaela Farukuoye,
    • Michaela Kacerovsky,
    • Albrecht I. Schmid,
    • Stephan Gruber,
    • Michael Wolzt,
    • Ewald Moser,
    • Giovanni Pacini,
    • Gerhard Smekal,
    • Leif Groop,
    • and Michael Roden

    Short-Term Exercise Training Does Not Stimulate Skeletal Muscle ATP Synthesis in Relatives of Humans With Type 2 Diabetes

    Diabetes June 2009 58:1333-1341; published ahead of print March 5, 2009, doi:10.2337/db08-1240
    • Chee W. Chia,
    • Olga D. Carlson,
    • Wook Kim,
    • Yu-Kyong Shin,
    • Cornelia P. Charles,
    • Hee Seung Kim,
    • Denise L. Melvin,
    • and Josephine M. Egan

    Exogenous Glucose–Dependent Insulinotropic Polypeptide Worsens Post prandial Hyperglycemia in T ype 2 Diabetes

    Diabetes June 2009 58:1342-1349; published ahead of print March 10, 2009, doi:10.2337/db08-0958
    • Pernille Poulsen,
    • Louise G. Grunnet,
    • Kasper Pilgaard,
    • Heidi Storgaard,
    • Amra Alibegovic,
    • Mette P. Sonne,
    • Bendix Carstensen,
    • Henning Beck-Nielsen,
    • and Allan Vaag

    Increased Risk of Type 2 Diabetes in Elderly Twins

    Diabetes June 2009 58:1350-1355; published ahead of print March 31, 2009, doi:10.2337/db08-1714

Complications

    • Elena Zherebitskaya,
    • Eli Akude,
    • Darrell R. Smith,
    • and Paul Fernyhough

    Development of Selective Axonopathy in Adult Sensory Neurons Isolated From Diabetic Rats: Role of Glucose-Induced Oxidative Stress

    Diabetes June 2009 58:1356-1364; published ahead of print February 27, 2009, doi:10.2337/db09-0034
    • Matthew M. Rankin and
    • Jake A. Kushner

    Adaptive β-Cell Proliferation Is Severely Restricted With Advanced Age

    Diabetes June 2009 58:1365-1372; published ahead of print March 5, 2009, doi:10.2337/db08-1198
    • Dirk Westermann,
    • Thomas Walther,
    • Konstantinos Savvatis,
    • Felcicitas Escher,
    • Meike Sobirey,
    • Alexander Riad,
    • Michael Bader,
    • Heinz-Peter Schultheiss,
    • and Carsten Tschöpe

    Gene Deletion of the Kinin Receptor B1 Attenuates Cardiac Inflammation and Fibrosis During the Development of Experimental Diabetic Cardiomyopathy

    Diabetes June 2009 58:1373-1381; published ahead of print March 10, 2009, doi:10.2337/db08-0329
    • Kamila C. Silva,
    • Mariana A.B. Rosales,
    • Subrata K. Biswas,
    • Jose B. Lopes de Faria,
    • and Jacqueline M. Lopes de Faria

    Diabetic Retinal Neurodegeneration Is Associated With Mitochondrial Oxidative Stress and Is Improved by an Angiotensin Receptor Blocker in a Model Combining Hypertension and Diabetes

    Diabetes June 2009 58:1382-1390; published ahead of print March 16, 2009, doi:10.2337/db09-0166
    • Yuehui Wang,
    • Wenke Feng,
    • Wanli Xue,
    • Yi Tan,
    • David W. Hein,
    • Xiao-Kun Li,
    • and Lu Cai

    Inactivation of GSK-3β by Metallothionein Prevents Diabetes-Related Changes in Cardiac Energy Metabolism, Inflammation, Nitrosative Damage, and Remodeling

    Diabetes June 2009 58:1391-1402; published ahead of print March 26, 2009, doi:10.2337/db08-1697

Genetics

    • Marcus G. Pezzolesi,
    • G. David Poznik,
    • Josyf C. Mychaleckyj,
    • Andrew D. Paterson,
    • Michelle T. Barati,
    • Jon B. Klein,
    • Daniel P.K. Ng,
    • Grzegorz Placha,
    • Luis H. Canani,
    • Jacek Bochenski,
    • Daryl Waggott,
    • Michael L. Merchant,
    • Bozena Krolewski,
    • Lucia Mirea,
    • Krzysztof Wanic,
    • Pisut Katavetin,
    • Masahiko Kure,
    • Pawel Wolkow,
    • Jonathon S. Dunn,
    • Adam Smiles,
    • William H. Walker,
    • Andrew P. Boright,
    • Shelley B. Bull,
    • the DCCT/EDIC Research Group,
    • Alessandro Doria,
    • John J. Rogus,
    • Stephen S. Rich,
    • James H. Warram,
    • and Andrzej S. Krolewski

    Genome-Wide Association Scan for Diabetic Nephropathy Susceptibility Genes in Type 1 Diabetes

    Diabetes June 2009 58:1403-1410; published ahead of print February 27, 2009, doi:10.2337/db08-1514
    • Ema C. Brito,
    • Valeriya Lyssenko,
    • Frida Renström,
    • Göran Berglund,
    • Peter M. Nilsson,
    • Leif Groop,
    • and Paul W. Franks

    Previously Associated Type 2 Diabetes Variants May Interact With Physical Activity to Modify the Risk of Impaired Glucose Regulation and Type 2 Diabetes: A Study of 16,003 Swedish Adults

    Diabetes June 2009 58:1411-1418; published ahead of print March 26, 2009, doi:10.2337/db08-1623
    • Samir Sayed,
    • David R. Langdon,
    • Stella Odili,
    • Pan Chen,
    • Carol Buettger,
    • Alisa B. Schiffman,
    • Mariko Suchi,
    • Rebecca Taub,
    • Joseph Grimsby,
    • Franz M. Matschinsky,
    • and Charles A. Stanley

    Extremes of Clinical and Enzymatic Phenotypes in Children With Hyperinsulinism Caused by Glucokinase Activating Mutations

    Diabetes June 2009 58:1419-1427; published ahead of print March 31, 2009, doi:10.2337/db08-1792
    • Rachel M. Freathy,
    • Amanda J. Bennett,
    • Susan M. Ring,
    • Beverley Shields,
    • Christopher J. Groves,
    • Nicholas J. Timpson,
    • Michael N. Weedon,
    • Eleftheria Zeggini,
    • Cecilia M. Lindgren,
    • Hana Lango,
    • John R.B. Perry,
    • Anneli Pouta,
    • Aimo Ruokonen,
    • Elina Hyppönen,
    • Chris Power,
    • Paul Elliott,
    • David P. Strachan,
    • Marjo-Riitta Järvelin,
    • George Davey Smith,
    • Mark I. McCarthy,
    • Timothy M. Frayling,
    • and Andrew T. Hattersley

    Type 2 Diabetes Risk Alleles Are Associated With Reduced Size at Birth

    Diabetes June 2009 58:1428-1433; published ahead of print February 19, 2009, doi:10.2337/db08-1739

Genetics

    • Kaixin Zhou,
    • Louise A. Donnelly,
    • Charlotte H. Kimber,
    • Peter T. Donnan,
    • Alex S.F. Doney,
    • Graham Leese,
    • Andrew T. Hattersley,
    • Mark I. McCarthy,
    • Andrew D. Morris,
    • Colin N.A. Palmer,
    • and Ewan R. Pearson

    Reduced-Function SLC22A1 Polymorphisms Encoding Organic Cation Transporter 1 and Glycemic Response to Metformin: A GoDARTS Study

    Diabetes June 2009 58:1434-1439; published ahead of print March 31, 2009, doi:10.2337/db08-0896
    • Mandy van Hoek,
    • Janneke G. Langendonk,
    • Susanne R. de Rooij,
    • Eric J.G. Sijbrands,
    • and Tessa J. Roseboom

    Genetic Variant in the IGF2BP2 Gene May Interact With Fetal Malnutrition to Affect Glucose Metabolism

    Diabetes June 2009 58:1440-1444; published ahead of print March 3, 2009, doi:10.2337/db08-1173
    • Jonathan T. Tan,
    • Siti Nurbaya,
    • Daphne Gardner,
    • Sandra Ye,
    • E. Shyong Tai,
    • and Daniel P.K. Ng

    Genetic Variation in KCNQ1 Associates With Fasting Glucose andβ-Cell Function: A Study of 3,734 Subjects Comprising Three Ethnicities Living in Singapore

    Diabetes June 2009 58:1445-1449; published ahead of print February 27, 2009, doi:10.2337/db08-1138
    • Thomas Sparsø,
    • Amélie Bonnefond,
    • Ehm Andersson,
    • Nabila Bouatia-Naji,
    • Johan Holmkvist,
    • Lise Wegner,
    • Niels Grarup,
    • Anette P. Gjesing,
    • Karina Banasik,
    • Christine Cavalcanti-Proença,
    • Marion Marchand,
    • Martine Vaxillaire,
    • Guillaume Charpentier,
    • Marjo-Riitta Jarvelin,
    • Jean Tichet,
    • Beverley Balkau,
    • Michel Marre,
    • Claire Lévy-Marchal,
    • Kristine Færch,
    • Knut Borch-Johnsen,
    • Torben Jørgensen,
    • Sten Madsbad,
    • Pernille Poulsen,
    • Allan Vaag,
    • Christian Dina,
    • Torben Hansen,
    • Oluf Pedersen,
    • and Philippe Froguel

    G-allele of Intronic rs10830963 in MTNR1B Confers Increased Risk of Impaired Fasting Glycemia and Type 2 Diabetes Through an Impaired Glucose-Stimulated Insulin Release: Studies Involving 19,605 Europeans

    Diabetes June 2009 58:1450-1456; published ahead of print March 26, 2009, doi:10.2337/db08-1660
    • Beth S. Sutton,
    • Nicholette D. Palmer,
    • Carl D. Langefeld,
    • Bingzhong Xue,
    • Alexandria Proctor,
    • Julie T. Ziegler,
    • Steven M. Haffner,
    • Jill M. Norris,
    • and Donald W. Bowden

    Association of SSTR2 Polymorphisms and Glucose Homeostasis Phenotypes: The Insulin Resistance Atherosclerosis Family Study

    Diabetes June 2009 58:1457-1462; published ahead of print March 26, 2009, doi:10.2337/db08-0189
    • John R.B. Perry,
    • Mark I. McCarthy,
    • Andrew T. Hattersley,
    • Eleftheria Zeggini,
    • the Wellcome Trust Case Control Consortium,
    • Michael N. Weedon,
    • and Timothy M. Frayling

    Interrogating Type 2 Diabetes Genome-Wide Association Data Using a Biological Pathway-Based Approach

    Diabetes June 2009 58:1463-1467; published ahead of print February 27, 2009, doi:10.2337/db08-1378
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This Issue

June 2009; 58 (6)
  1. Commentary
    1. Commentaries
  3. Original Article
    1. Metabolism
    2. Signal Transduction
    3. Immunology and Transplantation
    4. Islet Studies
    5. Pathophysiology
    6. Complications
    7. Genetics
  5. Genetics

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