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Additive Interaction Between the Renin-Angiotensin System and Lipid Metabolism for Cancer in Type 2 Diabetes

TABLE 3

Additive interactions of use of RAS inhibitors and statins for the risk of cancer in type 2 diabetes

Measures of additive interaction of RAS inhibitors with statins* Estimate (95% CI)
Model 1
    RERI 0.39 (0.09–0.69)
    AP 1.57 (0.21–2.94)
    S 0.66 (0.50–0.86)
Model 2
    RERI 0.53 (0.20–0.87)
    AP 2.65 (0.38–4.91)
    S 0.60 (0.46–0.78)
  • *Adjusted schemes for models 1 and 2 are available in Table 2.

  • †Statistically significant with RERI > 0, AP > 0, and S > 1 indicating additive interaction.

This Article

  1. Diabetes vol. 58 no. 7 1518-1525
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