High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans

Effects of Cold Exposure and Adiposity

  1. Masayuki Saito1,
  2. Yuko Okamatsu-Ogura2,
  3. Mami Matsushita1,
  4. Kumiko Watanabe1,
  5. Takeshi Yoneshiro1,
  6. Junko Nio-Kobayashi2,
  7. Toshihiko Iwanaga3,
  8. Masao Miyagawa4,
  9. Toshimitsu Kameya5,
  10. Kunihiro Nakada5,
  11. Yuko Kawai5 and
  12. Masayuki Tsujisaki5
  1. 1Department of Nutrition, School of Nursing and Nutrition, Tenshi College, Sapporo, Japan;
  2. 2Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan;
  3. 3Graduate School of Medicine, Hokkdaido University, Sapporo, Japan;
  4. 4PET Center, Ehime Hospital, Matsuyama, Japan;
  5. 5LSI Sapporo Clinic, Sapporo, Japan.
  1. Corresponding author: Masayuki Saito, saito{at}tenshi.ac.jp.

Abstract

OBJECTIVE The significant roles of brown adipose tissue (BAT) in the regulation of energy expenditure and adiposity are established in small rodents but have been controversial in humans. The objective is to examine the prevalence of metabolically active BAT in healthy adult humans and to clarify the effects of cold exposure and adiposity.

RESEARCH DESIGN AND METHODS In vivo 2-[18F]fluoro-2-deoxyglucose (FDG) uptake into adipose tissue was measured in 56 healthy volunteers (31 male and 25 female subjects) aged 23–65 years by positron emission tomography (PET) combined with X-ray computed tomography (CT).

RESULTS When exposed to cold (19°C) for 2 h, 17 of 32 younger subjects (aged 23–35 years) and 2 of 24 elderly subjects (aged 38–65 years) showed a substantial FDG uptake into adipose tissue of the supraclavicular and paraspinal regions, whereas they showed no detectable uptake when kept warm (27°C). Histological examinations confirmed the presence of brown adipocytes in these regions. The cold-activated FDG uptake was increased in winter compared with summer (P < 0.001) and was inversely related to BMI (P < 0.001) and total (P < 0.01) and visceral (P < 0.001) fat areas estimated from CT image at the umbilical level.

CONCLUSIONS Our findings, being against the conventional view, indicate the high incidence of metabolically active BAT in adult humans and suggest a role in the control of body temperature and adiposity.

Footnotes

  • The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

  • See accompanying commentary, p. 1482.

    • Received April 10, 2009.
    • Accepted April 15, 2009.
  • Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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  1. Diabetes vol. 58 no. 7 1526-1531
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