Majority of Children With Type 1 Diabetes Produce and Deposit Anti-Tissue Transglutaminase Antibodies in the Small Intestine

TABLE 1

Immunohistochemical findings in the small intestine of type 1 diabetic patients enrolled in this study

Group A Group B P
CD3+ >34/mm 6/14 (43) 4/19 (21) NS
γδ+ >3.4/mm 9/14 (64) 5/19 (26) <0.05
CD25+ >4/mm2 4/14 (29) 7/19 (37) NS
HLA-DR (++/+++) 10/14 (71) 11/19 (58) NS
ICAM-1 (++/+++) 4/14 (29) 6/19 (31) NS
  • Group A consisted of type 1 diabetic patients with elevated serum levels of anti-TG2 antibodies (TG2+). Group B consisted of type 1 diabetic patients with normal serum levels of anti-TG2 antibodies (TG2). CD3+ and γδ+ IELs are expressed per millimeter of epithelium; CD25+ cells are expressed per square millimeter of lamina propria. The expression of crypt epithelial HLA-DR and the expression of lamina propria ICAM-1 were evaluated in terms of their staining intensity and graded on an arbitrary scale of staining level, where − = no staining, + = weak staining, ++ = strong staining, and +++ = very strong staining. The data were analyzed by a χ2 test. P < 0.05 was considered significant.

This Article

  1. Diabetes vol. 58 no. 7 1578-1584