Table of Contents

Commentaries

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- Mikael Knip
Diet, Gut, and Type 1 Diabetes: Role of Wheat-Derived Peptides?
Diabetes August 2009 58:1723-1724; doi:10.2337/db09-0686
Select this article
- Helen E. Thomas and
- Trevor J. Biden
Bad News for β-Cell Apoptosis
Diabetes August 2009 58:1725-1727; doi:10.2337/db09-0732
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- Todd M. Brusko
Mesenchymal Stem Cells: A Potential Border Patrol for Transplanted Islets?
Diabetes August 2009 58:1728-1729; doi:10.2337/db09-0749
Select this article
- William T. Cefalu
Primary Prevention of Type 2 Diabetes: There Are No Simple Solutions!
Diabetes August 2009 58:1730-1731; doi:10.2337/db09-0840

Original Article

New Methodologies and Databases

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- Gertraud Maskarinec,
- Eva Erber,
- Andrew Grandinetti,
- Martijn Verheus,
- Robert Oum,
- Beth N. Hopping,
- Mark M. Schmidt,
- Aileen Uchida,
- Deborah Taira Juarez,
- Krista Hodges,
- and Laurence N. Kolonel
Diabetes Incidence Based on Linkages With Health Plans: The Multiethnic Cohort
Diabetes August 2009 58:1732-1738; published ahead of print March 3, 2009, doi:10.2337/db08-1685

Metabolism

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- Powen Tu,
- Shalender Bhasin,
- Paul W. Hruz,
- Karen L. Herbst,
- Lawrence W. Castellani,
- Ning Hua,
- James A. Hamilton,
- and Wen Guo
Genetic Disruption of Myostatin Reduces the Development of Proatherogenic Dyslipidemia and Atherogenic Lesions In Ldlr Null Mice
Diabetes August 2009 58:1739-1748; published ahead of print June 9, 2009, doi:10.2337/db09-0349
Select this article
- Alexandre A. da Silva,
- Jussara M. do Carmo,
- J. Nathan Freeman,
- Lakshmi S. Tallam,
- and John E. Hall
A Functional Melanocortin System May Be Required for Chronic CNS-Mediated Antidiabetic and Cardiovascular Actions of Leptin
Diabetes August 2009 58:1749-1756; published ahead of print June 2, 2009, doi:10.2337/db08-1221
Select this article
- Andreas Peter,
- Cora Weigert,
- Harald Staiger,
- Fausto Machicao,
- Fritz Schick,
- Jürgen Machann,
- Norbert Stefan,
- Claus Thamer,
- Hans-Ulrich Häring,
- and Erwin Schleicher
Individual Stearoyl-CoA Desaturase 1 Expression Modulates Endoplasmic Reticulum Stress and Inflammation in Human Myotubes and Is Associated With Skeletal Muscle Lipid Storage and Insulin Sensitivity In Vivo
Diabetes August 2009 58:1757-1765; published ahead of print May 28, 2009, doi:10.2337/db09-0188
Select this article
- John R. Ussher,
- Timothy R. Koves,
- Jagdip S. Jaswal,
- Liyan Zhang,
- Olga Ilkayeva,
- Jason R.B. Dyck,
- Deborah M. Muoio,
- and Gary D. Lopaschuk
Insulin-Stimulated Cardiac Glucose Oxidation Is Increased in High-Fat Diet–Induced Obese Mice Lacking Malonyl CoA Decarboxylase
Diabetes August 2009 58:1766-1775; published ahead of print May 28, 2009, doi:10.2337/db09-0011
Select this article
- Hendrik J.F. Helmerhorst,
- Katrien Wijndaele,
- Søren Brage,
- Nicholas J. Wareham,
- and Ulf Ekelund
Objectively Measured Sedentary Time May Predict Insulin Resistance Independent of Moderate- and Vigorous-Intensity Physical Activity
Diabetes August 2009 58:1776-1779; published ahead of print May 26, 2009, doi:10.2337/db08-1773

Obesity Studies

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- Katrina Kos,
- Steve Wong,
- Bee Tan,
- Anders Gummesson,
- Margareta Jernas,
- Niclas Franck,
- David Kerrigan,
- Fredrik H. Nystrom,
- Lena M.S. Carlsson,
- Harpal S. Randeva,
- Jonathan H. Pinkney,
- and John P.H. Wilding
Regulation of the Fibrosis and Angiogenesis Promoter SPARC/Osteonectin in Human Adipose Tissue by Weight Change, Leptin, Insulin, and Glucose
Diabetes August 2009 58:1780-1788; published ahead of print June 9, 2009, doi:10.2337/db09-0211

Immunology and Transplantation

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- Majid Mojibian,
- Habiba Chakir,
- David E. Lefebvre,
- Jennifer A. Crookshank,
- Brigitte Sonier,
- Erin Keely,
- and Fraser W. Scott
Diabetes-Specific HLA-DR–Restricted Proinflammatory T-Cell Response to Wheat Polypeptides in Tissue Transglutaminase Antibody–Negative Patients With Type 1 Diabetes
Diabetes August 2009 58:1789-1796; published ahead of print April 28, 2009, doi:10.2337/db08-1579
Select this article
- Yunchuan Ding,
- Danmei Xu,
- Gang Feng,
- Andrew Bushell,
- Ruth J. Muschel,
- and Kathryn J. Wood
Mesenchymal Stem Cells Prevent the Rejection of Fully Allogenic Islet Grafts by the Immunosuppressive Activity of Matrix Metalloproteinase-2 and -9
Diabetes August 2009 58:1797-1806; published ahead of print June 9, 2009, doi:10.2337/db09-0317

Islet Studies

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- Lars G. Grunnet,
- Reid Aikin,
- Morten F. Tonnesen,
- Steven Paraskevas,
- Lykke Blaabjerg,
- Joachim Størling,
- Lawrence Rosenberg,
- Nils Billestrup,
- Dusica Maysinger,
- and Thomas Mandrup-Poulsen
Proinflammatory Cytokines Activate the Intrinsic Apoptotic Pathway in β-Cells
Diabetes August 2009 58:1807-1815; published ahead of print May 26, 2009, doi:10.2337/db08-0178
Select this article
- Marion Cornu,
- Jiang-Yan Yang,
- Evrim Jaccard,
- Carine Poussin,
- Christian Widmann,
- and Bernard Thorens
Glucagon-Like Peptide-1 Protects β-Cells Against Apoptosis by Increasing the Activity of an Igf-2/Igf-1 Receptor Autocrine Loop
Diabetes August 2009 58:1816-1825; published ahead of print April 28, 2009, doi:10.2337/db09-0063
Select this article
- James Cantley,
- James G. Burchfield,
- Gemma L. Pearson,
- Carsten Schmitz-Peiffer,
- Michael Leitges,
- and Trevor J. Biden
Deletion of PKCε Selectively Enhances the Amplifying Pathways of Glucose-Stimulated Insulin Secretion via Increased Lipolysis in Mouse β-Cells
Diabetes August 2009 58:1826-1834; published ahead of print April 28, 2009, doi:10.2337/db09-0132
Select this article
- Martina Düfer,
- Belinda Gier,
- Daniela Wolpers,
- Peter Krippeit-Drews,
- Peter Ruth,
- and Gisela Drews
Enhanced Glucose Tolerance by SK4 Channel Inhibition in Pancreatic β-Cells
Diabetes August 2009 58:1835-1843; published ahead of print April 28, 2009, doi:10.2337/db08-1324
Select this article
- Jennifer B. Moss,
- Punita Koustubhan,
- Melanie Greenman,
- Michael J. Parsons,
- Ingrid Walter,
- and Larry G. Moss
Regeneration of the Pancreas in Adult Zebrafish
Diabetes August 2009 58:1844-1851; published ahead of print June 2, 2009, doi:10.2337/db08-0628
Select this article
- George Harb,
- Rupangi C. Vasavada,
- David Cobrinik,
- and Andrew F. Stewart
The Retinoblastoma Protein and Its Homolog p130 Regulate the G₁/S Transition in Pancreatic β-Cells
Diabetes August 2009 58:1852-1862; published ahead of print June 9, 2009, doi:10.2337/db08-0759
Select this article
- Takeshi Miyatsuka,
- Zhongmei Li,
- and Michael S. German
Chronology of Islet Differentiation Revealed By Temporal Cell Labeling
Diabetes August 2009 58:1863-1868; published ahead of print May 28, 2009, doi:10.2337/db09-0390

Pathophysiology

Select this article
- Dennis T. Villareal,
- Joseph C. Koster,
- Heather Robertson,
- Alejandro Akrouh,
- Kazuaki Miyake,
- Graeme I. Bell,
- Bruce W. Patterson,
- Colin G. Nichols,
- and Kenneth S. Polonsky
Kir6.2 Variant E23K Increases ATP-Sensitive K⁺ Channel Activity and Is Associated With Impaired Insulin Release and Enhanced Insulin Sensitivity in Adults With Normal Glucose Tolerance
Diabetes August 2009 58:1869-1878; published ahead of print June 2, 2009, doi:10.2337/db09-0025
Select this article
- Martina I. Lefterova,
- Shannon E. Mullican,
- Takuya Tomaru,
- Mohammed Qatanani,
- Michael Schupp,
- and Mitchell A. Lazar
Endoplasmic Reticulum Stress Regulates Adipocyte Resistin Expression
Diabetes August 2009 58:1879-1886; published ahead of print June 2, 2009, doi:10.2337/db08-1706
Select this article
- Seth S. Martin,
- Atif N. Qasim,
- Nehal N. Mehta,
- Megan Wolfe,
- Karen Terembula,
- Stanley Schwartz,
- Nayyar Iqbal,
- Mark Schutta,
- Roshanak Bagheri,
- and Muredach P. Reilly
Apolipoprotein B but not LDL Cholesterol Is Associated With Coronary Artery Calcification in Type 2 Diabetic Whites
Diabetes August 2009 58:1887-1892; published ahead of print June 2, 2009, doi:10.2337/db08-1794

Complications

Select this article
- Shuangxi Wang,
- Jian Xu,
- Ping Song,
- Benoit Viollet,
- and Ming-Hui Zou
In Vivo Activation of AMP-Activated Protein Kinase Attenuates Diabetes-Enhanced Degradation of GTP Cyclohydrolase I
Diabetes August 2009 58:1893-1901; published ahead of print June 15, 2009, doi:10.2337/db09-0267
Select this article
- Kyoungmin Park,
- Ying Chen,
- Yang Hu,
- Aaron S. Mayo,
- Uday B. Kompella,
- Richard Longeras,
- and Jian-xing Ma
Nanoparticle-Mediated Expression of an Angiogenic Inhibitor Ameliorates Ischemia-Induced Retinal Neovascularization and Diabetes-Induced Retinal Vascular Leakage
Diabetes August 2009 58:1902-1913; published ahead of print June 2, 2009, doi:10.2337/db08-1327
Select this article
- Johan Wadén,
- Carol Forsblom,
- Lena M. Thorn,
- Markku Saraheimo,
- Milla Rosengård-Bärlund,
- Outi Heikkilä,
- Kustaa Hietala,
- Ken Ong,
- Nicholas Wareham,
- and Per-Henrik Groop
Adult Stature and Diabetes Complications in Patients With Type 1 Diabetes: The FinnDiane Study and the Diabetes Control and Complications Trial
Diabetes August 2009 58:1914-1920; published ahead of print June 2, 2009, doi:10.2337/db08-1767

Pharmacology & Therapeutics

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- Yiqing Song,
- Nancy R. Cook,
- Christine M. Albert,
- Martin Van Denburgh,
- and JoAnn E. Manson
Effect of Homocysteine-Lowering Treatment With Folic Acid and B Vitamins on Risk of Type 2 Diabetes in Women: A Randomized, Controlled Trial
Diabetes August 2009 58:1921-1928; published ahead of print June 2, 2009, doi:10.2337/db09-0087

Genetics

Select this article
- Daniela Gašperíková,
- Nicolas D. Tribble,
- Juraj Staník,
- Miroslava Hučková,
- Nadežda Mišovicová,
- Martijn van de Bunt,
- Lucia Valentínová,
- Beryl A. Barrow,
- L'ubomir Barák,
- Radoslav Dobránsky,
- Eva Bereczková,
- Jozef Michálek,
- Kate Wicks,
- Kevin Colclough,
- Julian C. Knight,
- Sian Ellard,
- Iwar Klimeš,
- and Anna L. Gloyn
Identification of a Novel β-Cell Glucokinase (GCK) Promoter Mutation (−71G>C) That Modulates GCK Gene Expression Through Loss of Allele-Specific Sp1 Binding Causing Mild Fasting Hyperglycemia in Humans
Diabetes August 2009 58:1929-1935; published ahead of print May 1, 2009, doi:10.2337/db09-0070

Erratum

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Errata
Diabetes August 2009 58:1936; doi:10.2337/db09-er08
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Errata
Diabetes August 2009 58:1937; doi:10.2337/db09-er08b

Diabetes

Commentaries

Diet, Gut, and Type 1 Diabetes: Role of Wheat-Derived Peptides?

Bad News for β-Cell Apoptosis

Mesenchymal Stem Cells: A Potential Border Patrol for Transplanted Islets?

Primary Prevention of Type 2 Diabetes: There Are No Simple Solutions!

Original Article

New Methodologies and Databases

Diabetes Incidence Based on Linkages With Health Plans: The Multiethnic Cohort

Metabolism

Genetic Disruption of Myostatin Reduces the Development of Proatherogenic Dyslipidemia and Atherogenic Lesions In Ldlr Null Mice

A Functional Melanocortin System May Be Required for Chronic CNS-Mediated Antidiabetic and Cardiovascular Actions of Leptin

Individual Stearoyl-CoA Desaturase 1 Expression Modulates Endoplasmic Reticulum Stress and Inflammation in Human Myotubes and Is Associated With Skeletal Muscle Lipid Storage and Insulin Sensitivity In Vivo

Insulin-Stimulated Cardiac Glucose Oxidation Is Increased in High-Fat Diet–Induced Obese Mice Lacking Malonyl CoA Decarboxylase

Objectively Measured Sedentary Time May Predict Insulin Resistance Independent of Moderate- and Vigorous-Intensity Physical Activity

Obesity Studies

Regulation of the Fibrosis and Angiogenesis Promoter SPARC/Osteonectin in Human Adipose Tissue by Weight Change, Leptin, Insulin, and Glucose

Immunology and Transplantation

Diabetes-Specific HLA-DR–Restricted Proinflammatory T-Cell Response to Wheat Polypeptides in Tissue Transglutaminase Antibody–Negative Patients With Type 1 Diabetes

Mesenchymal Stem Cells Prevent the Rejection of Fully Allogenic Islet Grafts by the Immunosuppressive Activity of Matrix Metalloproteinase-2 and -9

Islet Studies

Proinflammatory Cytokines Activate the Intrinsic Apoptotic Pathway in β-Cells

Glucagon-Like Peptide-1 Protects β-Cells Against Apoptosis by Increasing the Activity of an Igf-2/Igf-1 Receptor Autocrine Loop

Deletion of PKCε Selectively Enhances the Amplifying Pathways of Glucose-Stimulated Insulin Secretion via Increased Lipolysis in Mouse β-Cells

Enhanced Glucose Tolerance by SK4 Channel Inhibition in Pancreatic β-Cells

Regeneration of the Pancreas in Adult Zebrafish

The Retinoblastoma Protein and Its Homolog p130 Regulate the G1/S Transition in Pancreatic β-Cells

Chronology of Islet Differentiation Revealed By Temporal Cell Labeling

Pathophysiology

Kir6.2 Variant E23K Increases ATP-Sensitive K+ Channel Activity and Is Associated With Impaired Insulin Release and Enhanced Insulin Sensitivity in Adults With Normal Glucose Tolerance

Endoplasmic Reticulum Stress Regulates Adipocyte Resistin Expression

Apolipoprotein B but not LDL Cholesterol Is Associated With Coronary Artery Calcification in Type 2 Diabetic Whites

Complications

In Vivo Activation of AMP-Activated Protein Kinase Attenuates Diabetes-Enhanced Degradation of GTP Cyclohydrolase I

Nanoparticle-Mediated Expression of an Angiogenic Inhibitor Ameliorates Ischemia-Induced Retinal Neovascularization and Diabetes-Induced Retinal Vascular Leakage

Adult Stature and Diabetes Complications in Patients With Type 1 Diabetes: The FinnDiane Study and the Diabetes Control and Complications Trial

Pharmacology & Therapeutics

Effect of Homocysteine-Lowering Treatment With Folic Acid and B Vitamins on Risk of Type 2 Diabetes in Women: A Randomized, Controlled Trial

Genetics

Identification of a Novel β-Cell Glucokinase (GCK) Promoter Mutation (−71G>C) That Modulates GCK Gene Expression Through Loss of Allele-Specific Sp1 Binding Causing Mild Fasting Hyperglycemia in Humans

Erratum

Errata

Errata

This Issue

Current Issue

The Retinoblastoma Protein and Its Homolog p130 Regulate the G₁/S Transition in Pancreatic β-Cells

Kir6.2 Variant E23K Increases ATP-Sensitive K⁺ Channel Activity and Is Associated With Impaired Insulin Release and Enhanced Insulin Sensitivity in Adults With Normal Glucose Tolerance