Diet, Gut, and Type 1 Diabetes: Role of Wheat-Derived Peptides?

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FIG. 1.
FIG. 1.

Proposed pathway for a wheat-induced intestinal inflammation in patients with type 1 diabetes. Wheat polypeptides pass through the apical junction system from the gut lumen to the mucosa and are presented to T-cells by dendritic cells (DCs) in an HLA DR-restricted manner. The activated T-cells stimulate T-helper type 1 (Th1) cells to produce γ-interferon (INF-γ) and tumor necrosis factor (TNF), Th2 cells to secrete IL-4, and Th17 cells to secrete IL-17A. This cytokine cascade results in local inflammation.

This Article

  1. Diabetes vol. 58 no. 8 1723-1724