Comment on: Perry et al. (2009) Interrogating Type 2 Diabetes Genome-Wide Association Data Using a Biological Pathway-Based Approach. Diabetes;58:1463–1467
- 1Department of Biomedical Genetics, Complex Genetics Section, University Medical Center Utrecht, Utrecht, the Netherlands;
- 2Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands;
- 3Department of Genetics, University Medical Center Groningen and University of Groningen, Groningen, the Netherlands.
- Corresponding author: N. Charlotte Onland-Moret, n.c.onland{at}umcutrecht.nl.
Perry et al. (1) performed a pathway-based approach aiming to identify biological pathways associated with type 2 diabetes. They used genome-wide association (GWA) data from the type 2 diabetes study in the U.K. Wellcome Trust Case Control Consortium (WTCCC) for the initial analysis and validated the findings with data from the Diabetes Genetics Initiative (DGI) and Finland–United States Investigation of NIDDM Genetics (FUSION) studies. The Wnt signaling pathway was the most strongly associated, and they therefore postulated this was the most interesting candidate pathway. However, after correcting for multiple testing, none of the …
