Table of Contents

Metabolism

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- Risheng Ye,
- Dae Young Jung,
- John Y. Jun,
- Jianze Li,
- Shengzhan Luo,
- Hwi Jin Ko,
- Jason K. Kim,
- and Amy S. Lee
Grp78 Heterozygosity Promotes Adaptive Unfolded Protein Response and Attenuates Diet-Induced Obesity and Insulin Resistance
Diabetes January 2010 59:6-16; published ahead of print October 6, 2009, doi:10.2337/db09-0755
Select this article
- Ying Cheng,
- Qingshu Meng,
- Chunxia Wang,
- Houkai Li,
- Zhiying Huang,
- Shanghai Chen,
- Fei Xiao,
- and Feifan Guo
Leucine Deprivation Decreases Fat Mass by Stimulation of Lipolysis in White Adipose Tissue and Upregulation of Uncoupling Protein 1 (UCP1) in Brown Adipose Tissue
Diabetes January 2010 59:17-25; published ahead of print October 15, 2009, doi:10.2337/db09-0929
Select this article
- Kristian Kiilerich,
- Mikkel Gudmundsson,
- Jesper B. Birk,
- Carsten Lundby,
- Sarah Taudorf,
- Peter Plomgaard,
- Bengt Saltin,
- Per A. Pedersen,
- Jorgen F.P. Wojtaszewski,
- and Henriette Pilegaard
Low Muscle Glycogen and Elevated Plasma Free Fatty Acid Modify but Do Not Prevent Exercise-Induced PDH Activation in Human Skeletal Muscle
Diabetes January 2010 59:26-32; published ahead of print October 15, 2009, doi:10.2337/db09-1032
Select this article
- Hyonson Hwang,
- Benjamin P. Bowen,
- Natalie Lefort,
- Charles R. Flynn,
- Elena A. De Filippis,
- Christine Roberts,
- Christopher C. Smoke,
- Christian Meyer,
- Kurt Højlund,
- Zhengping Yi,
- and Lawrence J. Mandarino
Proteomics Analysis of Human Skeletal Muscle Reveals Novel Abnormalities in Obesity and Type 2 Diabetes
Diabetes January 2010 59:33-42; published ahead of print October 15, 2009, doi:10.2337/db09-0214
Select this article
- Manuel Sanchez-Alavez,
- Iustin V. Tabarean,
- Olivia Osborn,
- Kayo Mitsukawa,
- Jean Schaefer,
- Jeffrey Dubins,
- Kristina H. Holmberg,
- Izabella Klein,
- Joe Klaus,
- Luis F. Gomez,
- Hartmuth Kolb,
- James Secrest,
- Jeanine Jochems,
- Kevin Myashiro,
- Peter Buckley,
- John R. Hadcock,
- James Eberwine,
- Bruno Conti,
- and Tamas Bartfai
Insulin Causes Hyperthermia by Direct Inhibition of Warm-Sensitive Neurons
Diabetes January 2010 59:43-50; published ahead of print October 21, 2009, doi:10.2337/db09-1128

Signal Transduction

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- Samson Mathews Samuel,
- Yuzo Akita,
- Debayon Paul,
- Mahesh Thirunavukkarasu,
- Lijun Zhan,
- Perumana R. Sudhakaran,
- Chuanfu Li,
- and Nilanjana Maulik
Coadministration of Adenoviral Vascular Endothelial Growth Factor and Angiopoietin-1 Enhances Vascularization and Reduces Ventricular Remodeling in the Infarcted Myocardium of Type 1 Diabetic Rats
Diabetes January 2010 59:51-60; published ahead of print September 30, 2009, doi:10.2337/db09-0336
Select this article
- Jennifer Jager,
- Thierry Grémeaux,
- Teresa Gonzalez,
- Stéphanie Bonnafous,
- Cyrille Debard,
- Martine Laville,
- Hubert Vidal,
- Albert Tran,
- Philippe Gual,
- Yannick Le Marchand-Brustel,
- Mireille Cormont,
- and Jean-François Tanti
Tpl2 Kinase Is Upregulated in Adipose Tissue in Obesity and May Mediate Interleukin-1β and Tumor Necrosis Factor-α Effects on Extracellular Signal–Regulated Kinase Activation and Lipolysis
Diabetes January 2010 59:61-70; published ahead of print October 6, 2009, doi:10.2337/db09-0470

Obesity Studies

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- Nora E. Straznicky,
- Elisabeth A. Lambert,
- Paul J. Nestel,
- Mariee T. McGrane,
- Tye Dawood,
- Markus P. Schlaich,
- Kazuko Masuo,
- Nina Eikelis,
- Barbora de Courten,
- Justin A. Mariani,
- Murray D. Esler,
- Florentia Socratous,
- Reena Chopra,
- Carolina I. Sari,
- Eldho Paul,
- and Gavin W. Lambert
Sympathetic Neural Adaptation to Hypocaloric Diet With or Without Exercise Training in Obese Metabolic Syndrome Subjects
Diabetes January 2010 59:71-79; published ahead of print October 15, 2009, doi:10.2337/db09-0934
Select this article
- Paul M. Coen,
- John J. Dubé,
- Francesca Amati,
- Maja Stefanovic-Racic,
- Robert E. Ferrell,
- Frederico G.S. Toledo,
- and Bret H. Goodpaster
Insulin Resistance Is Associated With Higher Intramyocellular Triglycerides in Type I but Not Type II Myocytes Concomitant With Higher Ceramide Content
Diabetes January 2010 59:80-88; published ahead of print October 15, 2009, doi:10.2337/db09-0988
Select this article
- Helen Karakelides,
- Brian A. Irving,
- Kevin R. Short,
- Peter O'Brien,
- and K. Sreekumaran Nair
Age, Obesity, and Sex Effects on Insulin Sensitivity and Skeletal Muscle Mitochondrial Function
Diabetes January 2010 59:89-97; published ahead of print October 15, 2009, doi:10.2337/db09-0591
Select this article
- Inagadapa J.N. Padmavathi,
- K. Rajender Rao,
- Lagishetty Venu,
- Manisha Ganeshan,
- K. Anand Kumar,
- Ch. Narasima Rao,
- Nemani Harishankar,
- Ayesha Ismail,
- and Manchala Raghunath
Chronic Maternal Dietary Chromium Restriction Modulates Visceral Adiposity: Probable Underlying Mechanisms
Diabetes January 2010 59:98-104; published ahead of print October 21, 2009, doi:10.2337/db09-0779
Select this article
- Erik Arner,
- Pål O. Westermark,
- Kirsty L. Spalding,
- Tom Britton,
- Mikael Rydén,
- Jonas Frisén,
- Samuel Bernard,
- and Peter Arner
Adipocyte Turnover: Relevance to Human Adipose Tissue Morphology
Diabetes January 2010 59:105-109; published ahead of print October 21, 2009, doi:10.2337/db09-0942

Immunology and Transplantation

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- Rebecca S. Tirabassi,
- Dennis L. Guberski,
- Elizabeth P. Blankenhorn,
- Jean H. Leif,
- Bruce A. Woda,
- Zhijun Liu,
- Donald Winans,
- Dale L. Greiner,
- and John P. Mordes
Infection With Viruses From Several Families Triggers Autoimmune Diabetes in LEW.1WR1 Rats: Prevention of Diabetes by Maternal Immunization
Diabetes January 2010 59:110-118; published ahead of print September 30, 2009, doi:10.2337/db09-0255

Islet Studies

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- Anita M. Hennige,
- Felicia Ranta,
- Isabel Heinzelmann,
- Martina Düfer,
- Diana Michael,
- Heidi Braumüller,
- Stefan Z. Lutz,
- Reiner Lammers,
- Gisela Drews,
- Fatima Bosch,
- Hans-Ulrich Häring,
- and Susanne Ullrich
Overexpression of Kinase-Negative Protein Kinase Cδ in Pancreatic β-Cells Protects Mice From Diet-Induced Glucose Intolerance and β-Cell Dysfunction
Diabetes January 2010 59:119-127; published ahead of print October 13, 2009, doi:10.2337/db09-0512
Select this article
- Michela Slucca,
- Jamie S. Harmon,
- Elizabeth A. Oseid,
- Joseph Bryan,
- and R. Paul Robertson
ATP-Sensitive K⁺ Channel Mediates the Zinc Switch-Off Signal for Glucagon Response During Glucose Deprivation
Diabetes January 2010 59:128-134; published ahead of print October 6, 2009, doi:10.2337/db09-1098
Select this article
- Omid Tavana,
- Nahum Puebla-Osorio,
- Mei Sang,
- and Chengming Zhu
Absence of p53-Dependent Apoptosis Combined With Nonhomologous End-Joining Deficiency Leads to a Severe Diabetic Phenotype in Mice
Diabetes January 2010 59:135-142; published ahead of print October 15, 2009, doi:10.2337/db09-0792
Select this article
- Hongjie Zhang,
- Jia Zhang,
- Christine F. Pope,
- Laura A. Crawford,
- Rupangi C. Vasavada,
- Shubhada M. Jagasia,
- and Maureen Gannon
Gestational Diabetes Mellitus Resulting From Impaired β-Cell Compensation in the Absence of FoxM1, a Novel Downstream Effector of Placental Lactogen
Diabetes January 2010 59:143-152; published ahead of print October 15, 2009, doi:10.2337/db09-0050
Select this article
- Nafeesa A. Noordeen,
- Tarnjit K. Khera,
- Gao Sun,
- E. Rebecca Longbottom,
- Timothy J. Pullen,
- Gabriela da Silva Xavier,
- Guy A. Rutter,
- and Isabelle Leclerc
Carbohydrate-Responsive Element-Binding Protein (ChREBP) Is a Negative Regulator of ARNT/HIF-1β Gene Expression in Pancreatic Islet β-Cells
Diabetes January 2010 59:153-160; published ahead of print October 15, 2009, doi:10.2337/db08-0868

Pathophysiology

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- Jacqueline F. Aitken,
- Kerry M. Loomes,
- David W. Scott,
- Shivanand Reddy,
- Anthony R.J. Phillips,
- Gordana Prijic,
- Chathurini Fernando,
- Shaoping Zhang,
- Ric Broadhurst,
- Phil L'Huillier,
- and Garth J.S. Cooper
Tetracycline Treatment Retards the Onset and Slows the Progression of Diabetes in Human Amylin/Islet Amyloid Polypeptide Transgenic Mice
Diabetes January 2010 59:161-171; published ahead of print September 30, 2009, doi:10.2337/db09-0548
Select this article
- Nehal N. Mehta,
- Fiona C. McGillicuddy,
- Paul D. Anderson,
- Christine C. Hinkle,
- Rachana Shah,
- Leticia Pruscino,
- Jennifer Tabita-Martinez,
- Kim F. Sellers,
- Michael R. Rickels,
- and Muredach P. Reilly
Experimental Endotoxemia Induces Adipose Inflammation and Insulin Resistance in Humans
Diabetes January 2010 59:172-181; published ahead of print September 30, 2009, doi:10.2337/db09-0367
Select this article
- Pia Thaning,
- Laurids T. Bune,
- Ylva Hellsten,
- Henriette Pilegaard,
- Bengt Saltin,
- and Jaya B. Rosenmeier
Attenuated Purinergic Receptor Function in Patients With Type 2 Diabetes
Diabetes January 2010 59:182-189; published ahead of print October 6, 2009, doi:10.2337/db09-1068
Select this article
- Alessia Fornoni,
- Jongmin Jeon,
- Javier Varona Santos,
- Lorenzo Cobianchi,
- Alexandra Jauregui,
- Luca Inverardi,
- Slavena A. Mandic,
- Christina Bark,
- Kevin Johnson,
- George McNamara,
- Antonello Pileggi,
- R. Damaris Molano,
- Jochen Reiser,
- Karl Tryggvason,
- Dontscho Kerjaschki,
- Per-Olof Berggren,
- Peter Mundel,
- and Camillo Ricordi
Nephrin Is Expressed on the Surface of Insulin Vesicles and Facilitates Glucose-Stimulated Insulin Release
Diabetes January 2010 59:190-199; published ahead of print October 15, 2009, doi:10.2337/db09-0655
Select this article
- José María Moreno-Navarrete,
- Rubén Martínez-Barricarte,
- Victoria Catalán,
- Mònica Sabater,
- Javier Gómez-Ambrosi,
- Francisco José Ortega,
- Wifredo Ricart,
- Mathias Blüher,
- Gema Frühbeck,
- Santiago Rodríguez de Cordoba,
- and José Manuel Fernández-Real
Complement Factor H Is Expressed in Adipose Tissue in Association With Insulin Resistance
Diabetes January 2010 59:200-209; published ahead of print October 15, 2009, doi:10.2337/db09-0700
Select this article
- Valma Harjutsalo,
- Niina Lammi,
- Marjatta Karvonen,
- and Per-Henrik Groop
Age at Onset of Type 1 Diabetes in Parents and Recurrence Risk in Offspring
Diabetes January 2010 59:210-214; published ahead of print October 15, 2009, doi:10.2337/db09-0344
Select this article
- Marietta Stadler,
- Christian Anderwald,
- Giovanni Pacini,
- Štefan Zbýň,
- Miriam Promintzer-Schifferl,
- Martina Mandl,
- Martin Bischof,
- Stephan Gruber,
- Peter Nowotny,
- Anton Luger,
- Rudolf Prager,
- and Michael Krebs
Chronic Peripheral Hyperinsulinemia in Type 1 Diabetic Patients After Successful Combined Pancreas-Kidney Transplantation Does Not Affect Ectopic Lipid Accumulation in Skeletal Muscle and Liver
Diabetes January 2010 59:215-218; published ahead of print October 15, 2009, doi:10.2337/db09-0354

Complications

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- Maria Tikhonenko,
- Todd A. Lydic,
- Yun Wang,
- Weiqin Chen,
- Madalina Opreanu,
- Andrew Sochacki,
- Kelly M. McSorley,
- Rebecca L. Renis,
- Timothy Kern,
- Donald B. Jump,
- Gavin E. Reid,
- and Julia V. Busik
Remodeling of Retinal Fatty Acids in an Animal Model of Diabetes: A Decrease in Long-Chain Polyunsaturated Fatty Acids Is Associated With a Decrease in Fatty Acid Elongases Elovl2 and Elovl4
Diabetes January 2010 59:219-227; published ahead of print October 29, 2009, doi:10.2337/db09-0728
Select this article
- Weiguo Li,
- Roshini Prakash,
- Aisha I. Kelly-Cobbs,
- Safia Ogbi,
- Anna Kozak,
- Azza B. El-Remessy,
- Derek A. Schreihofer,
- Susan C. Fagan,
- and Adviye Ergul
Adaptive Cerebral Neovascularization in a Model of Type 2 Diabetes: Relevance to Focal Cerebral Ischemia
Diabetes January 2010 59:228-235; published ahead of print October 6, 2009, doi:10.2337/db09-0902
Select this article
- Tamara Hershey,
- Dana C. Perantie,
- Jenny Wu,
- Patrick M. Weaver,
- Kevin J. Black,
- and Neil H. White
Hippocampal Volumes in Youth With Type 1 Diabetes
Diabetes January 2010 59:236-241; published ahead of print October 15, 2009, doi:10.2337/db09-1117
Select this article
- Susan Cheng,
- Joseph M. Massaro,
- Caroline S. Fox,
- Martin G. Larson,
- Michelle J. Keyes,
- Elizabeth L. McCabe,
- Sander J. Robins,
- Christopher J. O'Donnell,
- Udo Hoffmann,
- Paul F. Jacques,
- Sarah L. Booth,
- Ramachandran S. Vasan,
- Myles Wolf,
- and Thomas J. Wang
Adiposity, Cardiometabolic Risk, and Vitamin D Status: The Framingham Heart Study
Diabetes January 2010 59:242-248; published ahead of print October 15, 2009, doi:10.2337/db09-1011
Select this article
- Dachun Yao and
- Michael Brownlee
Hyperglycemia-Induced Reactive Oxygen Species Increase Expression of the Receptor for Advanced Glycation End Products (RAGE) and RAGE Ligands
Diabetes January 2010 59:249-255; published ahead of print October 15, 2009, doi:10.2337/db09-0801

Pharmacology and Therapeutics

Select this article
- Bei-Ying Qiu,
- Nigel Turner,
- Yuan-Yuan Li,
- Min Gu,
- Meng-Wei Huang,
- Fang Wu,
- Tao Pang,
- Fa-Jun Nan,
- Ji-Ming Ye,
- Jing-Ya Li,
- and Jia Li
High-Throughput Assay for Modulators of Mitochondrial Membrane Potential Identifies a Novel Compound With Beneficial Effects on db/db Mice
Diabetes January 2010 59:256-265; published ahead of print October 15, 2009, doi:10.2337/db09-0223

Genetics

Select this article
- Hana Lango Allen,
- Stefan Johansson,
- Sian Ellard,
- Beverley Shields,
- Jens K. Hertel,
- Helge Ræder,
- Kevin Colclough,
- Anders Molven,
- Timothy M. Frayling,
- Pål R. Njølstad,
- Andrew T. Hattersley,
- and Michael N. Weedon
Polygenic Risk Variants for Type 2 Diabetes Susceptibility Modify Age at Diagnosis in Monogenic HNF1A Diabetes
Diabetes January 2010 59:266-271; published ahead of print September 30, 2009, doi:10.2337/db09-0555
Select this article
- Jun Yamanouchi,
- Maria-Carmen Puertas,
- Joan Verdaguer,
- Paul A. Lyons,
- Daniel B. Rainbow,
- Giselle Chamberlain,
- Kara M. Hunter,
- Laurence B. Peterson,
- Linda S. Wicker,
- and Pere Santamaria
Idd9.1 Locus Controls the Suppressive Activity of FoxP3⁺CD4⁺CD25⁺ Regulatory T-Cells
Diabetes January 2010 59:272-281; published ahead of print October 15, 2009, doi:10.2337/db09-0648
Select this article
- Clive J. Petry,
- Mark L. Evans,
- Dianne L. Wingate,
- Ken K. Ong,
- Wolf Reik,
- Miguel Constância,
- and David B. Dunger
Raised Late Pregnancy Glucose Concentrations in Mice Carrying Pups With Targeted Disruption of H19^Δ13
Diabetes January 2010 59:282-286; published ahead of print September 30, 2009, doi:10.2337/db09-0757
Select this article
- Leen M. ‘t Hart,
- Annemarie M. Simonis-Bik,
- Giel Nijpels,
- Timon W. van Haeften,
- Silke A. Schäfer,
- Jeanine J. Houwing-Duistermaat,
- Dorret I. Boomsma,
- Marlous J. Groenewoud,
- Erwin Reiling,
- Els C. van Hove,
- Michaela Diamant,
- Mark H.H. Kramer,
- Robert J. Heine,
- J. Antonie Maassen,
- Kerstin Kirchhoff,
- Fausto Machicao,
- Hans-Ulrich Häring,
- P. Eline Slagboom,
- Gonneke Willemsen,
- Elisabeth M. Eekhoff,
- Eco J. de Geus,
- Jacqueline M. Dekker,
- and Andreas Fritsche
Combined Risk Allele Score of Eight Type 2 Diabetes Genes Is Associated With Reduced First-Phase Glucose-Stimulated Insulin Secretion During Hyperglycemic Clamps
Diabetes January 2010 59:287-292; published ahead of print October 6, 2009, doi:10.2337/db09-0736
Select this article
- Annemarie M. Simonis-Bik,
- Giel Nijpels,
- Timon W. van Haeften,
- Jeanine J. Houwing-Duistermaat,
- Dorret I. Boomsma,
- Erwin Reiling,
- Els C. van Hove,
- Michaela Diamant,
- Mark H.H. Kramer,
- Robert J. Heine,
- J. Antonie Maassen,
- P. Eline Slagboom,
- Gonneke Willemsen,
- Jacqueline M. Dekker,
- Elisabeth M. Eekhoff,
- Eco J. de Geus,
- and Leen M. 't Hart
Gene Variants in the Novel Type 2 Diabetes Loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B Affect Different Aspects of Pancreatic β-Cell Function
Diabetes January 2010 59:293-301; published ahead of print October 15, 2009, doi:10.2337/db09-1048
Select this article
- Elin Pettersen,
- Frank Skorpen,
- Kirsti Kvaløy,
- Kristian Midthjell,
- and Valdemar Grill
Genetic Heterogeneity in Latent Autoimmune Diabetes Is Linked to Various Degrees of Autoimmune Activity: Results From the Nord-Trøndelag Health Study
Diabetes January 2010 59:302-310; published ahead of print October 15, 2009, doi:10.2337/db09-0923
Select this article
- David Meyre,
- Karine Proulx,
- Hiroko Kawagoe-Takaki,
- Vincent Vatin,
- Ruth Gutiérrez-Aguilar,
- Debbie Lyon,
- Marcella Ma,
- Helene Choquet,
- Fritz Horber,
- Wim Van Hul,
- Luc Van Gaal,
- Beverley Balkau,
- Sophie Visvikis-Siest,
- François Pattou,
- I. Sadaf Farooqi,
- Vladimir Saudek,
- Stephen O'Rahilly,
- Philippe Froguel,
- Barbara Sedgwick,
- and Giles S.H. Yeo
Prevalence of Loss-of-Function FTO Mutations in Lean and Obese Individuals
Diabetes January 2010 59:311-318; published ahead of print October 15, 2009, doi:10.2337/db09-0703

Diabetes

Commentaries

PKCδ Blues for the β-Cell

The Final Frontier: How Does Diabetes Affect the Brain?

Original Article

Metabolism

Grp78 Heterozygosity Promotes Adaptive Unfolded Protein Response and Attenuates Diet-Induced Obesity and Insulin Resistance

Leucine Deprivation Decreases Fat Mass by Stimulation of Lipolysis in White Adipose Tissue and Upregulation of Uncoupling Protein 1 (UCP1) in Brown Adipose Tissue

Low Muscle Glycogen and Elevated Plasma Free Fatty Acid Modify but Do Not Prevent Exercise-Induced PDH Activation in Human Skeletal Muscle

Proteomics Analysis of Human Skeletal Muscle Reveals Novel Abnormalities in Obesity and Type 2 Diabetes

Insulin Causes Hyperthermia by Direct Inhibition of Warm-Sensitive Neurons

Signal Transduction

Coadministration of Adenoviral Vascular Endothelial Growth Factor and Angiopoietin-1 Enhances Vascularization and Reduces Ventricular Remodeling in the Infarcted Myocardium of Type 1 Diabetic Rats

Tpl2 Kinase Is Upregulated in Adipose Tissue in Obesity and May Mediate Interleukin-1β and Tumor Necrosis Factor-α Effects on Extracellular Signal–Regulated Kinase Activation and Lipolysis

Obesity Studies

Sympathetic Neural Adaptation to Hypocaloric Diet With or Without Exercise Training in Obese Metabolic Syndrome Subjects

Insulin Resistance Is Associated With Higher Intramyocellular Triglycerides in Type I but Not Type II Myocytes Concomitant With Higher Ceramide Content

Age, Obesity, and Sex Effects on Insulin Sensitivity and Skeletal Muscle Mitochondrial Function

Chronic Maternal Dietary Chromium Restriction Modulates Visceral Adiposity: Probable Underlying Mechanisms

Adipocyte Turnover: Relevance to Human Adipose Tissue Morphology

Immunology and Transplantation

Infection With Viruses From Several Families Triggers Autoimmune Diabetes in LEW.1WR1 Rats: Prevention of Diabetes by Maternal Immunization

Islet Studies

Overexpression of Kinase-Negative Protein Kinase Cδ in Pancreatic β-Cells Protects Mice From Diet-Induced Glucose Intolerance and β-Cell Dysfunction

ATP-Sensitive K+ Channel Mediates the Zinc Switch-Off Signal for Glucagon Response During Glucose Deprivation

Absence of p53-Dependent Apoptosis Combined With Nonhomologous End-Joining Deficiency Leads to a Severe Diabetic Phenotype in Mice

Gestational Diabetes Mellitus Resulting From Impaired β-Cell Compensation in the Absence of FoxM1, a Novel Downstream Effector of Placental Lactogen

Carbohydrate-Responsive Element-Binding Protein (ChREBP) Is a Negative Regulator of ARNT/HIF-1β Gene Expression in Pancreatic Islet β-Cells

Pathophysiology

Tetracycline Treatment Retards the Onset and Slows the Progression of Diabetes in Human Amylin/Islet Amyloid Polypeptide Transgenic Mice

Experimental Endotoxemia Induces Adipose Inflammation and Insulin Resistance in Humans

Attenuated Purinergic Receptor Function in Patients With Type 2 Diabetes

Nephrin Is Expressed on the Surface of Insulin Vesicles and Facilitates Glucose-Stimulated Insulin Release

Complement Factor H Is Expressed in Adipose Tissue in Association With Insulin Resistance

Age at Onset of Type 1 Diabetes in Parents and Recurrence Risk in Offspring

Chronic Peripheral Hyperinsulinemia in Type 1 Diabetic Patients After Successful Combined Pancreas-Kidney Transplantation Does Not Affect Ectopic Lipid Accumulation in Skeletal Muscle and Liver

Complications

Remodeling of Retinal Fatty Acids in an Animal Model of Diabetes: A Decrease in Long-Chain Polyunsaturated Fatty Acids Is Associated With a Decrease in Fatty Acid Elongases Elovl2 and Elovl4

Adaptive Cerebral Neovascularization in a Model of Type 2 Diabetes: Relevance to Focal Cerebral Ischemia

Hippocampal Volumes in Youth With Type 1 Diabetes

Adiposity, Cardiometabolic Risk, and Vitamin D Status: The Framingham Heart Study

Hyperglycemia-Induced Reactive Oxygen Species Increase Expression of the Receptor for Advanced Glycation End Products (RAGE) and RAGE Ligands

Pharmacology and Therapeutics

High-Throughput Assay for Modulators of Mitochondrial Membrane Potential Identifies a Novel Compound With Beneficial Effects on db/db Mice

Genetics

Polygenic Risk Variants for Type 2 Diabetes Susceptibility Modify Age at Diagnosis in Monogenic HNF1A Diabetes

Idd9.1 Locus Controls the Suppressive Activity of FoxP3+CD4+CD25+ Regulatory T-Cells

Raised Late Pregnancy Glucose Concentrations in Mice Carrying Pups With Targeted Disruption of H19Δ13

Combined Risk Allele Score of Eight Type 2 Diabetes Genes Is Associated With Reduced First-Phase Glucose-Stimulated Insulin Secretion During Hyperglycemic Clamps

Gene Variants in the Novel Type 2 Diabetes Loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B Affect Different Aspects of Pancreatic β-Cell Function

Genetic Heterogeneity in Latent Autoimmune Diabetes Is Linked to Various Degrees of Autoimmune Activity: Results From the Nord-Trøndelag Health Study

Prevalence of Loss-of-Function FTO Mutations in Lean and Obese Individuals

Errata

Errata

Errata

This Issue

Current Issue

ATP-Sensitive K⁺ Channel Mediates the Zinc Switch-Off Signal for Glucagon Response During Glucose Deprivation

Idd9.1 Locus Controls the Suppressive Activity of FoxP3⁺CD4⁺CD25⁺ Regulatory T-Cells

Raised Late Pregnancy Glucose Concentrations in Mice Carrying Pups With Targeted Disruption of H19^Δ13