Decreased IRS Signaling Impairs β-Cell Cycle Progression and Survival in Transgenic Mice Overexpressing S6K in β-Cells
- Lynda Elghazi1,
- Norman Balcazar1,
- Manuel Blandino-Rosano1,
- Corentin Cras-Méneur1,
- Szabolcs Fatrai1,
- Aaron P. Gould1,
- Maggie M. Chi2,
- Kelle H. Moley2 and
- Ernesto Bernal-Mizrachi1
- 1Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, Brehm Center for Diabetes Research, University of Michigan, Ann Arbor, Michigan;
- 2Department of Obstetrics/Gynecology, Washington University School of Medicine, St. Louis, Missouri.
- Corresponding author: Ernesto Bernal-Mizrachi, .
L.E. and N.B. contributed equally to this manuscript.