Impact of Physical Inactivity on Subcutaneous Adipose Tissue Metabolism in Healthy Young Male Offspring of Patients With Type 2 Diabetes

TABLE 3

Basal subcutaneous adipose tissue interstitial and plasma water concentrations of metabolites

CON FDR
Before BR After BR Before BR After BR
Interstitial glucose abdominal (μM) 4.4 ± 0.2 (n = 19)* 3.6 ± 0.4 (n = 18)* 4.0 ± 0.5 (n = 11)* 4.5 ± 0.3 (n = 13)*
Interstitial glucose femoral (μM) 4.7 ± 0.2 (n = 19)* 4.0 ± 0.2 (n = 19)* 5.7 ± 0.4 (n = 11)* 4.3 ± 0.3 (n = 11)*
Arterial plasma water glucose (μM) 5.3 ± 0.1 (n = 20) 5.1 ± 0.1 (n = 20) 5.9 ± 0.1 (n = 13) 5.6 ± 0.1 (n = 13)
Interstitial glycerol abdominal (μM) 235 ± 29 (n = 20) 172 ± 13 (n = 20)* 228 ± 40 (n = 13)* 241 ± 39 (n = 12)*
Interstitial glycerol femoral (μM) 309 ± 38 (n = 20) 232 ± 34 (n = 19)* 355 ± 49 (n = 11)* 205 ± 29 (n = 12)*
Arterial plasma water glycerol (μM) 36 ± 3 (n = 20) 33 ± 2 (n = 20) 42 ± 4 (n = 13) 36 ± 3 (n = 13)
Interstitial lactate abdominal (μM) 2.7 ± 0.2 (n = 19)* 3.0 ± 0.3 (n = 18)* 3.1 ± 0.5 (n = 10)* 3.0 ± 0.3 (n = 13)*
Interstitial lactate femoral (μM) 2.8 ± 0.3 (n = 19)* 3.1 ± 0.3 (n = 19)* 2.8 ± 0.2 (n = 10)* 2.6 ± 0.3 (n = 12)*
Arterial plasma water lactate (μM) 0.8 ± 0.06 (n = 20) 0.8 ± 0.05 (n = 20) 0.8 ± 0.08 (n = 13) 0.8 ± 0.05 (n = 13)
  • Data are mean ± SE.

  • *Significant difference interstitial vs. arterial plasma water concentration, P < 0.05. BR, bed rest.

This Article

  1. Diabetes vol. 59 no. 11 2790-2798