Comment on: Yang et al. (2010) Associations of Hyperglycemia and Insulin Usage With the Risk of Cancer in Type 2 Diabetes: The Hong Kong Diabetes Registry. Diabetes;59:1254–1260

  1. Laura Sciacca
  1. From the Endocrinology Division, Department of Clinical and Molecular Biomedicine, University of Catania, Garibaldi-Nesima Hospital, Catania, Italy.
  1. Corresponding author: Riccardo Vigneri, vigneri{at}

By analyzing data from the Hong Kong Diabetes Registry, Yang et al. (1) conclude that insulin use is associated with a reduced cancer risk in type 2 diabetes. The authors hypothesize that insulin treatment, by causing tighter glycemic control, less oxidative stress, and less inflammation, reduces the risk of cancer. We believe that the study presents serious methodological problems regarding patient matching as well as follow-up and that the conclusions are unrealistic.

From the original cohort of 4,623 diabetic patients, including 169 patients who developed cancer among insulin nonusers (4.6 vs. 3.3% among insulin …

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