Associations of Six Single Nucleotide Polymorphisms in Obesity-Related Genes With BMI and Risk of Obesity in Chinese Children
- Lijun Wu1,
- Bo Xi1,
- Meixian Zhang1,
- Yue Shen2,
- Xiaoyuan Zhao1,
- Hong Cheng1,
- Dongqing Hou1,
- Dandan Sun3,
- Jurg Ott3,
- Xingyu Wang2 and
- Jie Mi1
- 1Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China;
- 2Laboratory of Human Genetics, Beijing Hypertension League Institute, Beijing, China;
- 3Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
- Corresponding authors: Xingyu Wang, , and Jie Mi, .
L.W., B.X., and M.Z. contributed equally to this study.
OBJECTIVE Childhood obesity strongly predisposes to some adult diseases. Recently, genome-wide association (GWA) studies in Caucasians identified multiple single nucleotide polymorphisms (SNPs) associated with BMI and obesity. The associations of those SNPs with BMI and obesity among other ethnicities are not fully described, especially in children. Among those previously identified SNPs, we selected six (rs7138803, rs1805081, rs6499640, rs17782313, rs6265, and rs10938397, in or near obesity-related genes FAIM2, NPC1, FTO, MC4R, BDNF, and GNPDA2, respectively) because of the relatively high minor allele frequencies in Chinese individuals and tested the associations of the SNPs with BMI and obesity in Chinese children.
RESEARCH DESIGN AND METHODS We investigated the associations of these SNPs with BMI and obesity in school-aged children. A total of 3,503 children participated in the study, including 1,229 obese, 655 overweight, and 1,619 normal-weight children (diagnosed by the Chinese age- and sex-specific BMI cutoffs).
RESULTS After age and sex adjustment and correction for multiple testing, the SNPs rs17782313, rs6265, and rs10938397 were associated with BMI (P = 1.0 × 10−5, 0.038, and 0.00093, respectively) and also obesity (P = 5.0 × 10−6, 0.043, and 0.00085, respectively) in the Chinese children. The SNPs rs17782313 and rs10938397 were also significantly associated with waist circumference, waist-to-height ratio, and fat mass percentage.
CONCLUSIONS Results of this study support obesity-related genes in adults as important genes for BMI variation in children and suggest that some SNPs identified by GWA studies in Caucasians also confer risk for obesity in Chinese children.
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- Received February 24, 2010.
- Accepted September 5, 2010.
- © 2010 by the American Diabetes Association.
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