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Table of Contents

February 2010; 59 (2)

Perspectives in Diabetes

    • Andrew A. Butler and
    • Leslie P. Kozak

    A Recurring Problem With the Analysis of Energy Expenditure in Genetic Models Expressing Lean and Obese Phenotypes

    Diabetes February 2010 59:323-329; doi:10.2337/db09-1471

Commentaries

    • R. David Leslie

    Predicting Adult-Onset Autoimmune Diabetes: Clarity From Complexity

    Diabetes February 2010 59:330-331; doi:10.2337/db09-1620
    • Jose C. Florez

    A Genome-Wide Association Study of Treated A1C: A Genetic Needle in an Environmental Haystack?

    Diabetes February 2010 59:332-334; doi:10.2337/db09-1636
    • John C. Hutton and
    • Howard W. Davidson

    Cytokine-Induced Dicing and Splicing in the β-Cell and the Immune Response in Type 1 Diabetes

    Diabetes February 2010 59:335-336; doi:10.2337/db09-1767

Original Article

Metabolism

    • Hua V. Lin,
    • Leona Plum,
    • Hiraku Ono,
    • Roger Gutiérrez-Juárez,
    • Marya Shanabrough,
    • Erzsebet Borok,
    • Tamas L. Horvath,
    • Luciano Rossetti,
    • and Domenico Accili

    Divergent Regulation of Energy Expenditure and Hepatic Glucose Production by Insulin Receptor in Agouti-Related Protein and POMC Neurons

    Diabetes February 2010 59:337-346; published ahead of print November 23, 2009, doi:10.2337/db09-1303
    • Wan Huang,
    • Anantha Metlakunta,
    • Nikolaos Dedousis,
    • Pili Zhang,
    • Ian Sipula,
    • John J. Dube,
    • Donald K. Scott,
    • and Robert M. O'Doherty

    Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance

    Diabetes February 2010 59:347-357; published ahead of print November 23, 2009, doi:10.2337/db09-0016

Signal Transduction

    • Fernanda Ortis,
    • Najib Naamane,
    • Daisy Flamez,
    • Laurence Ladrière,
    • Fabrice Moore,
    • Daniel A. Cunha,
    • Maikel L. Colli,
    • Thomas Thykjaer,
    • Kasper Thorsen,
    • Torben F. Ørntoft,
    • and Decio L. Eizirik

    Cytokines Interleukin-1β and Tumor Necrosis Factor-α Regulate Different Transcriptional and Alternative Splicing Networks in Primary β-Cells

    Diabetes February 2010 59:358-374; published ahead of print November 23, 2009, doi:10.2337/db09-1159
    • Christopher Lipina,
    • Clare Stretton,
    • Simon Hastings,
    • Jonathan S. Hundal,
    • Ken Mackie,
    • Andrew J. Irving,
    • and Harinder S. Hundal

    Regulation of MAP Kinase–Directed Mitogenic and Protein Kinase B–Mediated Signaling by Cannabinoid Receptor Type 1 in Skeletal Muscle Cells

    Diabetes February 2010 59:375-385; published ahead of print November 23, 2009, doi:10.2337/db09-0979

Obesity Studies

    • Chang Yeop Han,
    • Atil Y. Kargi,
    • Mohamed Omer,
    • Christina K. Chan,
    • Martin Wabitsch,
    • Kevin D. O'Brien,
    • Thomas N. Wight,
    • and Alan Chait

    Differential Effect of Saturated and Unsaturated Free Fatty Acids on the Generation of Monocyte Adhesion and Chemotactic Factors by Adipocytes: Dissociation of Adipocyte Hypertrophy From Inflammation

    Diabetes February 2010 59:386-396; published ahead of print November 23, 2009, doi:10.2337/db09-0925
    • James V. Gardiner,
    • Attia Bataveljic,
    • Neekhil A. Patel,
    • Gavin A. Bewick,
    • Debabrata Roy,
    • Daniel Campbell,
    • Hannah C. Greenwood,
    • Kevin G. Murphy,
    • Saira Hameed,
    • Preeti H. Jethwa,
    • Francis J.P. Ebling,
    • Steven P. Vickers,
    • Sharon Cheetham,
    • Mohammad A. Ghatei,
    • Stephen R. Bloom,
    • and Waljit S. Dhillo

    Prokineticin 2 Is a Hypothalamic Neuropeptide That Potently Inhibits Food Intake

    Diabetes February 2010 59:397-406; published ahead of print November 23, 2009, doi:10.2337/db09-1198

Immunology and Transplantation

    • S. Alice Long,
    • Karen Cerosaletti,
    • Paul L. Bollyky,
    • Megan Tatum,
    • Heather Shilling,
    • Sheng Zhang,
    • Zhong-Yin Zhang,
    • Catherine Pihoker,
    • Srinath Sanda,
    • Carla Greenbaum,
    • and Jane H. Buckner

    Defects in IL-2R Signaling Contribute to Diminished Maintenance of FOXP3 Expression in CD4+CD25+ Regulatory T-Cells of Type 1 Diabetic Subjects

    Diabetes February 2010 59:407-415; published ahead of print October 29, 2009, doi:10.2337/db09-0694
    • Virve M. Lundgren,
    • Bo Isomaa,
    • Valeriya Lyssenko,
    • Esa Laurila,
    • Pasi Korhonen,
    • Leif C. Groop,
    • Tiinamaija Tuomi,
    • and for the Botnia Study Group

    GAD Antibody Positivity Predicts Type 2 Diabetes in an Adult Population

    Diabetes February 2010 59:416-422; published ahead of print October 28, 2009, doi:10.2337/db09-0747
    • John P. Driver,
    • Felix Scheuplein,
    • Yi-Guang Chen,
    • Alexandra E. Grier,
    • S. Brian Wilson,
    • and David V. Serreze

    Invariant Natural Killer T-Cell Control of Type 1 Diabetes: A Dendritic Cell Genetic Decision of a Silver Bullet or Russian Roulette

    Diabetes February 2010 59:423-432; published ahead of print November 10, 2009, doi:10.2337/db09-1116
    • Nicola Gagliani,
    • Tatiana Jofra,
    • Angela Stabilini,
    • Andrea Valle,
    • Mark Atkinson,
    • Maria-Grazia Roncarolo,
    • and Manuela Battaglia

    Antigen-Specific Dependence of Tr1-Cell Therapy in Preclinical Models of Islet Transplant

    Diabetes February 2010 59:433-439; published ahead of print November 23, 2009, doi:10.2337/db09-1168

Islet Studies

    • Junqin Chen,
    • Ghislaine Fontes,
    • Geetu Saxena,
    • Vincent Poitout,
    • and Anath Shalev

    Lack of TXNIP Protects Against Mitochondria-Mediated Apoptosis but Not Against Fatty Acid–Induced ER Stress–Mediated β-Cell Death

    Diabetes February 2010 59:440-447; published ahead of print October 29, 2009, doi:10.2337/db09-0949
    • Hongfang Lu,
    • Vasilij Koshkin,
    • Emma M. Allister,
    • Armen V. Gyulkhandanyan,
    • and Michael B. Wheeler

    Molecular and Metabolic Evidence for Mitochondrial Defects Associated With β-Cell Dysfunction in a Mouse Model of Type 2 Diabetes

    Diabetes February 2010 59:448-459; published ahead of print November 10, 2009, doi:10.2337/db09-0129
    • David J. Lloyd,
    • Matthew C. Wheeler,
    • and Nicholas Gekakis

    A Point Mutation in Sec61α1 Leads to Diabetes and Hepatosteatosis in Mice

    Diabetes February 2010 59:460-470; published ahead of print November 23, 2009, doi:10.2337/db08-1362
    • Dong Wei,
    • Jie Li,
    • Miaoda Shen,
    • Wei Jia,
    • Nuoqi Chen,
    • Tao Chen,
    • Dongming Su,
    • Haoming Tian,
    • Shusen Zheng,
    • Yifan Dai,
    • and Allan Zhao

    Cellular Production of n-3 PUFAs and Reduction of n-6–to–n-3 Ratios in the Pancreatic β-Cells and Islets Enhance Insulin Secretion and Confer Protection Against Cytokine-Induced Cell Death

    Diabetes February 2010 59:471-478; published ahead of print November 23, 2009, doi:10.2337/db09-0284

Pathophysiology

    • Dennis T. Villareal,
    • Heather Robertson,
    • Graeme I. Bell,
    • Bruce W. Patterson,
    • Hung Tran,
    • Burton Wice,
    • and Kenneth S. Polonsky

    TCF7L2 Variant rs7903146 Affects the Risk of Type 2 Diabetes by Modulating Incretin Action

    Diabetes February 2010 59:479-485; published ahead of print November 23, 2009, doi:10.2337/db09-1169
    • Chris R. Cardwell,
    • Lars C. Stene,
    • Geir Joner,
    • Max K. Bulsara,
    • Ondrej Cinek,
    • Joachim Rosenbauer,
    • Johnny Ludvigsson,
    • Mireia Jané,
    • Jannet Svensson,
    • Michael J. Goldacre,
    • Thomas Waldhoer,
    • Przemysława Jarosz-Chobot,
    • Suely G.A. Gimeno,
    • Lee-Ming Chuang,
    • Roger C. Parslow,
    • Emma J.K. Wadsworth,
    • Amanda Chetwynd,
    • Paolo Pozzilli,
    • Girts Brigis,
    • Brone Urbonaitė,
    • Sandra Šipetić,
    • Edith Schober,
    • Gabriele Devoti,
    • Constantin Ionescu-Tirgoviste,
    • Carine E. de Beaufort,
    • Denka Stoyanov,
    • Karsten Buschard,
    • and Chris C. Patterson

    Maternal Age at Birth and Childhood Type 1 Diabetes: A Pooled Analysis of 30 Observational Studies

    Diabetes February 2010 59:486-494; published ahead of print October 29, 2009, doi:10.2337/db09-1166
    • Erica P. Gunderson,
    • David R. Jacobs, Jr,
    • Vicky Chiang,
    • Cora E. Lewis,
    • Juanran Feng,
    • Charles P. Quesenberry, Jr,
    • and Stephen Sidney

    Duration of Lactation and Incidence of the Metabolic Syndrome in Women of Reproductive Age According to Gestational Diabetes Mellitus Status: A 20-Year Prospective Study in CARDIA (Coronary Artery Risk Development in Young Adults)

    Diabetes February 2010 59:495-504; published ahead of print December 3, 2009, doi:10.2337/db09-1197

Complications

    • Elizabeth J. Pawson,
    • Beatriz Duran-Jimenez,
    • Richard Surosky,
    • Heather E. Brooke,
    • S. Kaye Spratt,
    • David R. Tomlinson,
    • and Natalie J. Gardiner

    Engineered Zinc Finger Protein–Mediated VEGF-A Activation Restores Deficient VEGF-A in Sensory Neurons in Experimental Diabetes

    Diabetes February 2010 59:509-518; published ahead of print November 23, 2009, doi:10.2337/db08-1526
    • Xavier Fioramonti,
    • Nicolas Marsollier,
    • Zhentao Song,
    • Kurt A. Fakira,
    • Reema M. Patel,
    • Stacey Brown,
    • Thibaut Duparc,
    • Arnaldo Pica-Mendez,
    • Nicole M. Sanders,
    • Claude Knauf,
    • Philippe Valet,
    • Rory J. McCrimmon,
    • Annie Beuve,
    • Christophe Magnan,
    • and Vanessa H. Routh

    Ventromedial Hypothalamic Nitric Oxide Production Is Necessary for Hypoglycemia Detection and Counterregulation

    Diabetes February 2010 59:519-528; published ahead of print November 23, 2009, doi:10.2337/db09-0421

Pharmacology and Therapeutics

    • Gavin Y. Oudit,
    • George C. Liu,
    • JiuChang Zhong,
    • Ratnadeep Basu,
    • Fung L. Chow,
    • Joyce Zhou,
    • Hans Loibner,
    • Evelyne Janzek,
    • Manfred Schuster,
    • Josef M. Penninger,
    • Andrew M. Herzenberg,
    • Zamaneh Kassiri,
    • and James W. Scholey

    Human Recombinant ACE2 Reduces the Progression of Diabetic Nephropathy

    Diabetes February 2010 59:529-538; published ahead of print November 23, 2009, doi:10.2337/db09-1218

Genetics

    • Andrew D. Paterson,
    • Daryl Waggott,
    • Andrew P. Boright,
    • S. Mohsen Hosseini,
    • Enqing Shen,
    • Marie-Pierre Sylvestre,
    • Isidro Wong,
    • Bhupinder Bharaj,
    • Patricia A. Cleary,
    • John M. Lachin,
    • MAGIC (Meta-Analyses of Glucose and Insulin-related traits Consortium),
    • Jennifer E. Below,
    • Dan Nicolae,
    • Nancy J. Cox,
    • Angelo J. Canty,
    • Lei Sun,
    • Shelley B. Bull,
    • and the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group

    A Genome-Wide Association Study Identifies a Novel Major Locus for Glycemic Control in Type 1 Diabetes, as Measured by Both A1C and Glucose

    Diabetes February 2010 59:539-549; published ahead of print October 29, 2009, doi:10.2337/db09-0653

Pathophysiology

    • Michael P. Brugts,
    • Cornelia M. van Duijn,
    • Leo J. Hofland,
    • Jacqueline C. Witteman,
    • Steven W.J. Lamberts,
    • and Joseph A.M.J.L. Janssen

    IGF-I Bioactivity in an Elderly Population: Relation to Insulin Sensitivity, Insulin Levels, and the Metabolic Syndrome

    Diabetes February 2010 59:505-508; doi:10.2337/db09-0583
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This Issue

February 2010; 59 (2)
  1. Perspectives in Diabetes
  2. Commentaries
  3. Original Article
    1. Metabolism
    2. Signal Transduction
    3. Obesity Studies
    4. Immunology and Transplantation
    5. Islet Studies
    6. Pathophysiology
    7. Complications
    8. Pharmacology and Therapeutics
    9. Genetics
  5. Pathophysiology

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