Molecular and Metabolic Evidence for Mitochondrial Defects Associated With β-Cell Dysfunction in a Mouse Model of Type 2 Diabetes
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Mouse characterization and islet glucose-stimulated insulin secretion and ATP/ADP ratio. Fasting plasma insulin (A) and blood glucose levels (B). Islets from age-matched MKR and WT mice were exposed to 2.8 or 20 mmol/l glucose. C and D: Islet insulin secretion during 1 h in 3- and 10-week-old islets. GSIS from 5-week-old islets is shown in Fig. S1. E and F: Total islet ATP/ADP ratio. (n = 3 independent experiments with five mice per genotype.) Data are means ± SE. *P < 0.05; **P < 0.01; ***P < 0.001 MKR compared with age-matched WT unless otherwise indicated.