Comment on: Song et al. (2009) Effect of Homocysteine-Lowering Treatment With Folic Acid and B Vitamins on Risk of Type 2 Diabetes in Women

A Randomized, Controlled Trial. Diabetes 58:1921–1928

  1. Chu-Huang Chen3,4,5
  1. 1Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan;
  2. 2Department of Biochemistry and Molecular Biology, National Taiwan University College of Medicine, Taipei, Taiwan;
  3. 3Department of Medicine, China Medical University Hospital, Taichung, Taiwan;
  4. 4Vascular and Medicinal Research, Texas Heart Institute at St. Luke's Episcopal Hospital, Houston, Texas;
  5. 5Department of Medicine, Baylor College of Medicine, Houston, Texas.
  1. Corresponding author: Chu-Huang Chen, cchen{at}heart.thi.tmc.edu.

The Diabetes article by Song et al. (1) presents the results of the first randomized, controlled trial to analyze the long-term effects of folic acid and vitamin B supplementation on the risk of developing type 2 diabetes in women at high risk for cardiovascular disease. Daily supplements significantly lowered homocysteine levels but did not reduce the risk of developing type 2 diabetes. Their results do not support previous findings indicating …

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