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Table of Contents

April 2010; 59 (4)

Banting Lecture

    • George S. Eisenbarth

    Banting Lecture 2009: An Unfinished Journey: Molecular Pathogenesis to Prevention of Type 1A Diabetes

    Diabetes April 2010 59:759-774; doi:10.2337/db09-1855

Original Article

Metabolism

    • Partha Chakrabarti,
    • Taylor English,
    • Jun Shi,
    • Cynthia M. Smas,
    • and Konstantin V. Kandror

    Mammalian Target of Rapamycin Complex 1 Suppresses Lipolysis, Stimulates Lipogenesis, and Promotes Fat Storage

    Diabetes April 2010 59:775-781; published ahead of print January 12, 2010, doi:10.2337/db09-1602
    • Scott Robertson,
    • Ryoko Ishida-Takahashi,
    • Isao Tawara,
    • Jiang Hu,
    • Christa M. Patterson,
    • Justin C. Jones,
    • Rohit N. Kulkarni,
    • and Martin G. Myers, Jr

    Insufficiency of Janus Kinase 2–Autonomous Leptin Receptor Signals for Most Physiologic Leptin Actions

    Diabetes April 2010 59:782-790; published ahead of print January 12, 2010, doi:10.2337/db09-1556
    • Nanlan Luo,
    • Jian Liu,
    • B. Hong Chung,
    • Qinglin Yang,
    • Richard L. Klein,
    • W. Timothy Garvey,
    • and Yuchang Fu

    Macrophage Adiponectin Expression Improves Insulin Sensitivity and Protects Against Inflammation and Atherosclerosis

    Diabetes April 2010 59:791-799; doi:10.2337/db09-1338
    • Beth A. Griesel,
    • Juston Weems,
    • Robert A. Russell,
    • E. Dale Abel,
    • Kenneth Humphries,
    • and Ann Louise Olson

    Acute Inhibition of Fatty Acid Import Inhibits GLUT4 Transcription in Adipose Tissue, but Not Skeletal or Cardiac Muscle Tissue, Partly Through Liver X Receptor (LXR) Signaling

    Diabetes April 2010 59:800-807; published ahead of print January 26, 2010, doi:10.2337/db09-1542
    • Yael Riahi,
    • Yoav Sin-Malia,
    • Guy Cohen,
    • Evgenia Alpert,
    • Arie Gruzman,
    • Juergen Eckel,
    • Bart Staels,
    • Michel Guichardant,
    • and Shlomo Sasson

    The Natural Protective Mechanism Against Hyperglycemia in Vascular Endothelial Cells: Roles of the Lipid Peroxidation Product 4-Hydroxydodecadienal and Peroxisome Proliferator–Activated Receptor δ

    Diabetes April 2010 59:808-818; published ahead of print January 27, 2010, doi:10.2337/db09-1207
    • Graham P. Holloway,
    • Brendon J. Gurd,
    • Laelie A. Snook,
    • Jamie Lally,
    • and Arend Bonen

    Compensatory Increases in Nuclear PGC1α Protein Are Primarily Associated With Subsarcolemmal Mitochondrial Adaptations in ZDF Rats

    Diabetes April 2010 59:819-828; published ahead of print January 26, 2010, doi:10.2337/db09-1519
    • Jarno Rutanen,
    • Nagendra Yaluri,
    • Shalem Modi,
    • Jussi Pihlajamäki,
    • Markku Vänttinen,
    • Paula Itkonen,
    • Sakari Kainulainen,
    • Hiroyasu Yamamoto,
    • Marie Lagouge,
    • David A. Sinclair,
    • Peter Elliott,
    • Christoph Westphal,
    • Johan Auwerx,
    • and Markku Laakso

    SIRT1 mRNA Expression May Be Associated With Energy Expenditure and Insulin Sensitivity

    Diabetes April 2010 59:829-835; published ahead of print January 27, 2010, doi:10.2337/db09-1191
    • Amra C. Alibegovic,
    • Mette P. Sonne,
    • Lise Højbjerre,
    • Torben Hansen,
    • Oluf Pedersen,
    • Gerrit van Hall,
    • Jens J. Holst,
    • Bente Stallknecht,
    • Flemming Dela,
    • and Allan Vaag

    The T-Allele of TCF7L2 rs7903146 Associates With a Reduced Compensation of Insulin Secretion for Insulin Resistance Induced by 9 Days of Bed Rest

    Diabetes April 2010 59:836-843; published ahead of print January 27, 2010, doi:10.2337/db09-0918

Signal Transduction

    • Tilo Wuensch,
    • Florian Thilo,
    • Katharina Krueger,
    • Alexandra Scholze,
    • Michael Ristow,
    • and Martin Tepel

    High Glucose–Induced Oxidative Stress Increases Transient Receptor Potential Channel Expression in Human Monocytes

    Diabetes April 2010 59:844-849; published ahead of print January 12, 2010, doi:10.2337/db09-1100
    • Tao Jiang,
    • Zheping Huang,
    • Yifeng Lin,
    • Zhigang Zhang,
    • Deyu Fang,
    • and Donna D. Zhang

    The Protective Role of Nrf2 in Streptozotocin-Induced Diabetic Nephropathy

    Diabetes April 2010 59:850-860; published ahead of print January 26, 2010, doi:10.2337/db09-1342
    • Alexandre Charbonneau and
    • André Marette

    Inducible Nitric Oxide Synthase Induction Underlies Lipid-Induced Hepatic Insulin Resistance in Mice: Potential Role of Tyrosine Nitration of Insulin Signaling Proteins

    Diabetes April 2010 59:861-871; published ahead of print January 26, 2010, doi:10.2337/db09-1238

Obesity Studies

    • Ivy K.M. Law,
    • Aimin Xu,
    • Karen S.L. Lam,
    • Thorsten Berger,
    • Tak W. Mak,
    • Paul M. Vanhoutte,
    • Jacky T.C. Liu,
    • Gary Sweeney,
    • Mingyan Zhou,
    • Bo Yang,
    • and Yu Wang

    Lipocalin-2 Deficiency Attenuates Insulin Resistance Associated With Aging and Obesity

    Diabetes April 2010 59:872-882; published ahead of print January 12, 2010, doi:10.2337/db09-1541
    • Chi Bun Chan,
    • Xia Liu,
    • Dae Young Jung,
    • John Y. Jun,
    • Hongbo R. Luo,
    • Jason K. Kim,
    • and Keqiang Ye

    Deficiency of Phosphoinositide 3-Kinase Enhancer Protects Mice From Diet-Induced Obesity and Insulin Resistance

    Diabetes April 2010 59:883-893; published ahead of print January 12, 2010, doi:10.2337/db09-1404
    • Alison S. Reed,
    • Elizabeth K. Unger,
    • Louise E. Olofsson,
    • Merisa L. Piper,
    • Martin G. Myers, Jr,
    • and Allison W. Xu

    Functional Role of Suppressor of Cytokine Signaling 3 Upregulation in Hypothalamic Leptin Resistance and Long-Term Energy Homeostasis

    Diabetes April 2010 59:894-906; published ahead of print January 12, 2010, doi:10.2337/db09-1024
    • Dong-Hoon Kim,
    • Stephen C. Woods,
    • and Randy J. Seeley

    Peptide Designed to Elicit Apoptosis in Adipose Tissue Endothelium Reduces Food Intake and Body Weight

    Diabetes April 2010 59:907-915; published ahead of print January 26, 2010, doi:10.2337/db09-1141
    • Amrom E. Obstfeld,
    • Eiji Sugaru,
    • Marie Thearle,
    • Anne-Marie Francisco,
    • Constance Gayet,
    • Henry N. Ginsberg,
    • Eleanore V. Ables,
    • and Anthony W. Ferrante, Jr

    C-C Chemokine Receptor 2 (CCR2) Regulates the Hepatic Recruitment of Myeloid Cells That Promote Obesity-Induced Hepatic Steatosis

    Diabetes April 2010 59:916-925; published ahead of print January 26, 2010, doi:10.2337/db09-1403
    • Tony Jourdan,
    • Louiza Djaouti,
    • Laurent Demizieux,
    • Joseph Gresti,
    • Bruno Vergès,
    • and Pascal Degrace

    CB1 Antagonism Exerts Specific Molecular Effects on Visceral and Subcutaneous Fat and Reverses Liver Steatosis in Diet-Induced Obese Mice

    Diabetes April 2010 59:926-934; published ahead of print January 28, 2010, doi:10.2337/db09-1482
    • Florian W. Kiefer,
    • Maximilian Zeyda,
    • Karina Gollinger,
    • Birgit Pfau,
    • Angelika Neuhofer,
    • Thomas Weichhart,
    • Marcus D. Säemann,
    • René Geyeregger,
    • Michaela Schlederer,
    • Lukas Kenner,
    • and Thomas M. Stulnig

    Neutralization of Osteopontin Inhibits Obesity-Induced Inflammation and Insulin Resistance

    Diabetes April 2010 59:935-946; published ahead of print January 27, 2010, doi:10.2337/db09-0404

Immunology and Transplantation

    • Francesco Vendrame,
    • Antonello Pileggi,
    • Elsa Laughlin,
    • Gloria Allende,
    • Ainhoa Martin-Pagola,
    • R. Damaris Molano,
    • Stavros Diamantopoulos,
    • Nathan Standifer,
    • Kelly Geubtner,
    • Ben A. Falk,
    • Hirohito Ichii,
    • Hidenori Takahashi,
    • Isaac Snowhite,
    • Zhibin Chen,
    • Armando Mendez,
    • Linda Chen,
    • Junichiro Sageshima,
    • Phillip Ruiz,
    • Gaetano Ciancio,
    • Camillo Ricordi,
    • Helena Reijonen,
    • Gerald T. Nepom,
    • George W. Burke III,
    • and Alberto Pugliese

    Recurrence of Type 1 Diabetes After Simultaneous Pancreas-Kidney Transplantation, Despite Immunosuppression, Is Associated With Autoantibodies and Pathogenic Autoreactive CD4 T-Cells

    Diabetes April 2010 59:947-957; published ahead of print January 19, 2010, doi:10.2337/db09-0498
    • Hossein Arefanian,
    • Eric B. Tredget,
    • Ray V. Rajotte,
    • Ron G. Gill,
    • Gregory S. Korbutt,
    • and Gina R. Rayat

    Short-Term Administrations of a Combination of Anti–LFA-1 and Anti-CD154 Monoclonal Antibodies Induce Tolerance to Neonatal Porcine Islet Xenografts in Mice

    Diabetes April 2010 59:958-966; published ahead of print January 19, 2010, doi:10.2337/db09-0413

Islet Studies

    • Anjaneyulu Kowluru,
    • Rajakrishnan Veluthakal,
    • Christopher J. Rhodes,
    • Vasudeva Kamath,
    • Ismail Syed,
    • and Brandon J. Koch

    Protein Farnesylation–Dependent Raf/Extracellular Signal–Related Kinase Signaling Links to Cytoskeletal Remodeling to Facilitate Glucose-Induced Insulin Secretion in Pancreatic β-Cells

    Diabetes April 2010 59:967-977; published ahead of print January 13, 2010, doi:10.2337/db09-1334
    • Elodie Roggli,
    • Aurore Britan,
    • Sonia Gattesco,
    • Nathalie Lin-Marq,
    • Amar Abderrahmani,
    • Paolo Meda,
    • and Romano Regazzi

    Involvement of MicroRNAs in the Cytotoxic Effects Exerted by Proinflammatory Cytokines on Pancreatic β-Cells

    Diabetes April 2010 59:978-986; published ahead of print January 19, 2010, doi:10.2337/db09-0881
    • Senta Georgia,
    • Charlotte Hinault,
    • Dan Kawamori,
    • Jiang Hu,
    • John Meyer,
    • Murtaza Kanji,
    • Anil Bhushan,
    • and Rohit N. Kulkarni

    Cyclin D2 Is Essential for the Compensatory β-Cell Hyperplastic Response to Insulin Resistance in Rodents

    Diabetes April 2010 59:987-996; published ahead of print January 26, 2010, doi:10.2337/db09-0838

Pathophysiology

    • Xizhen Xu,
    • Chun Xia Zhao,
    • Luyun Wang,
    • Ling Tu,
    • Xiaosai Fang,
    • Changlong Zheng,
    • Matthew L. Edin,
    • Darryl C. Zeldin,
    • and Dao Wen Wang

    Increased CYP2J3 Expression Reduces Insulin Resistance in Fructose-Treated Rats and db/db Mice

    Diabetes April 2010 59:997-1005; published ahead of print January 12, 2010, doi:10.2337/db09-1241
    • Saula Vigili de Kreutzenberg,
    • Giulio Ceolotto,
    • Italia Papparella,
    • Alessia Bortoluzzi,
    • Andrea Semplicini,
    • Chiara Dalla Man,
    • Claudio Cobelli,
    • Gian Paolo Fadini,
    • and Angelo Avogaro

    Downregulation of the Longevity-Associated Protein Sirtuin 1 in Insulin Resistance and Metabolic Syndrome: Potential Biochemical Mechanisms

    Diabetes April 2010 59:1006-1015; published ahead of print January 12, 2010, doi:10.2337/db09-1187
    • Gabriele Togliatto,
    • Antonella Trombetta,
    • Patrizia Dentelli,
    • Alessandra Baragli,
    • Arturo Rosso,
    • Riccarda Granata,
    • Dario Ghigo,
    • Luigi Pegoraro,
    • Ezio Ghigo,
    • and Maria Felice Brizzi

    Unacylated Ghrelin Rescues Endothelial Progenitor Cell Function in Individuals With Type 2 Diabetes

    Diabetes April 2010 59:1016-1025; published ahead of print January 12, 2010, doi:10.2337/db09-0858

Complications

    • Masayuki Arakawa,
    • Tomoya Mita,
    • Kosuke Azuma,
    • Chie Ebato,
    • Hiromasa Goto,
    • Takashi Nomiyama,
    • Yoshio Fujitani,
    • Takahisa Hirose,
    • Ryuzo Kawamori,
    • and Hirotaka Watada

    Inhibition of Monocyte Adhesion to Endothelial Cells and Attenuation of Atherosclerotic Lesion by a Glucagon-like Peptide-1 Receptor Agonist, Exendin-4

    Diabetes April 2010 59:1030-1037; published ahead of print January 12, 2010, doi:10.2337/db09-1694
    • Naila Rabbani,
    • Madhu Varma Chittari,
    • Charles W. Bodmer,
    • Daniel Zehnder,
    • Antonio Ceriello,
    • and Paul J. Thornalley

    Increased Glycation and Oxidative Damage to Apolipoprotein B100 of LDL Cholesterol in Patients With Type 2 Diabetes and Effect of Metformin

    Diabetes April 2010 59:1038-1045; published ahead of print January 12, 2010, doi:10.2337/db09-1455
    • Federica Barutta,
    • Alessandro Corbelli,
    • Raffaella Mastrocola,
    • Roberto Gambino,
    • Vincenzo Di Marzo,
    • Silvia Pinach,
    • Maria Pia Rastaldi,
    • Paolo Cavallo Perin,
    • and Gabriella Gruden

    Cannabinoid Receptor 1 Blockade Ameliorates Albuminuria in Experimental Diabetic Nephropathy

    Diabetes April 2010 59:1046-1054; published ahead of print January 12, 2010, doi:10.2337/db09-1336
    • Erwin C. Puente,
    • Julie Silverstein,
    • Adam J. Bree,
    • Daniel R. Musikantow,
    • David F. Wozniak,
    • Susan Maloney,
    • Dorit Daphna-Iken,
    • and Simon J. Fisher

    Recurrent Moderate Hypoglycemia Ameliorates Brain Damage and Cognitive Dysfunction Induced by Severe Hypoglycemia

    Diabetes April 2010 59:1055-1062; published ahead of print January 19, 2010, doi:10.2337/db09-1495
    • Meghan Sauvé,
    • Kiwon Ban,
    • M. Abdul Momen,
    • Yu-Qing Zhou,
    • R. Mark Henkelman,
    • Mansoor Husain,
    • and Daniel J. Drucker

    Genetic Deletion or Pharmacological Inhibition of Dipeptidyl Peptidase-4 Improves Cardiovascular Outcomes After Myocardial Infarction in Mice

    Diabetes April 2010 59:1063-1073; published ahead of print January 22, 2010, doi:10.2337/db09-0955
    • Maka S. Hedrington,
    • Stephnie Farmerie,
    • Andrew C. Ertl,
    • Zhihui Wang,
    • Donna B. Tate,
    • and Stephen N. Davis

    Effects of Antecedent GABAA Activation With Alprazolam on Counterregulatory Responses to Hypoglycemia in Healthy Humans

    Diabetes April 2010 59:1074-1081; published ahead of print January 19, 2010, doi:10.2337/db09-1520
    • Subir K. Roy Chowdhury,
    • Elena Zherebitskaya,
    • Darrell R. Smith,
    • Eli Akude,
    • Sharmila Chattopadhyay,
    • Corinne G. Jolivalt,
    • Nigel A. Calcutt,
    • and Paul Fernyhough

    Mitochondrial Respiratory Chain Dysfunction in Dorsal Root Ganglia of Streptozotocin-Induced Diabetic Rats and Its Correction by Insulin Treatment

    Diabetes April 2010 59:1082-1091; published ahead of print January 26, 2010, doi:10.2337/db09-1299

Pharmacology and Therapeutics

    • Nahoko Sato,
    • Masayuki Kaneko,
    • Mitsutaka Tamura,
    • and Hajimu Kurumatani

    The Prostacyclin Analog Beraprost Sodium Ameliorates Characteristics of Metabolic Syndrome in Obese Zucker (Fatty) Rats

    Diabetes April 2010 59:1092-1100; published ahead of print January 12, 2010, doi:10.2337/db09-1432
    • Manfred Hallschmid,
    • Kamila Jauch-Chara,
    • Oliver Korn,
    • Matthias Mölle,
    • Björn Rasch,
    • Jan Born,
    • Bernd Schultes,
    • and Werner Kern

    Euglycemic Infusion of Insulin Detemir Compared With Human Insulin Appears to Increase Direct Current Brain Potential Response and Reduces Food Intake While Inducing Similar Systemic Effects

    Diabetes April 2010 59:1101-1107; published ahead of print January 12, 2010, doi:10.2337/db09-1493

Brief Report

Pathophysiology

    • Agnieszka Nikolajuk,
    • Irina Kowalska,
    • Monika Karczewska-Kupczewska,
    • Agnieszka Adamska,
    • Elzbieta Otziomek,
    • Slawomir Wolczynski,
    • Ida Kinalska,
    • Maria Gorska,
    • and Marek Straczkowski

    Serum Soluble Glycoprotein 130 Concentration Is Inversely Related to Insulin Sensitivity in Women With Polycystic Ovary Syndrome

    Diabetes April 2010 59:1026-1029; published ahead of print January 26, 2010, doi:10.2337/db09-1316

Genetics

    • Rasmus Ribel-Madsen,
    • Pernille Poulsen,
    • Johan Holmkvist,
    • Brynjulf Mortensen,
    • Niels Grarup,
    • Martin Friedrichsen,
    • Torben Jørgensen,
    • Torsten Lauritzen,
    • Jørgen F.P. Wojtaszewski,
    • Oluf Pedersen,
    • Torben Hansen,
    • and Allan Vaag

    Impact of rs361072 in the Phosphoinositide 3-Kinase p110β Gene on Whole-Body Glucose Metabolism and Subunit Protein Expression in Skeletal Muscle

    Diabetes April 2010 59:1108-1112; published ahead of print January 27, 2010, doi:10.2337/db09-1359

Errata

  • Errata

    Diabetes April 2010 59:1113; doi:10.2337/db10-er04a

  • Errata

    Diabetes April 2010 59:1113-1114; doi:10.2337/db10-er04

Online Letters to the Editor

    • John B. Vincent and
    • Jane F. Rasco

    Comment on: Padmavathi et al. (2010) Chronic Maternal Dietary Chromium Restriction Modulates Visceral Adiposity: Probable Underlying Mechanisms. Diabetes;59:98–104

    Diabetes April 2010 59:e2; doi:10.2337/db10-0043
    • Inagadapa J.N. Padmavathi,
    • Venu Lagishetty,
    • and Manchala Raghunath

    Response to Comment on: Padmavathi et al. (2010) Chronic Maternal Dietary Chromium Restriction Modulates Visceral Adiposity: Probable Underlying Mechanisms. Diabetes;59:98–104

    Diabetes April 2010 59:e3; doi:10.2337/db10-0116
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This Issue

April 2010; 59 (4)
  1. Banting Lecture
  2. Original Article
    1. Metabolism
    2. Signal Transduction
    3. Obesity Studies
    4. Immunology and Transplantation
    5. Islet Studies
    6. Pathophysiology
    7. Complications
    8. Pharmacology and Therapeutics
  4. Brief Report
    1. Pathophysiology
    2. Genetics
  6. Errata
  7. Online Letters to the Editor

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