Increased CYP2J3 Expression Reduces Insulin Resistance in Fructose-Treated Rats and db/db Mice
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Effects of CYP2J3 gene delivery on urinary cAMP and cGMP levels. A: Levels of urinary cAMP were increased in rats 2 weeks after injection with CYP2J3+ compared with levels observed after injection with the empty pcDNA3.1 vector. B: Urinary cGMP levels were increased in rats injected with CYP2J3+ compared with those injected with the empty pcDNA vector. *P < 0.05 versus pcDNA-treated and normal water–treated rats; #P < 0.05 versus pcDNA-treated and fructose-treated rats; n = 8 per group.