Increased CYP2J3 Expression Reduces Insulin Resistance in Fructose-Treated Rats and db/db Mice

TABLE 1

Physiological parameters determined in rats after 3 weeks of administration of control or fructose-containing drinking water

Variables Control group (n = 32) Fructose-treated group (n = 24)
Glucose (mmol/l) 4.91 ± 0.2 5.62 ± 0.4
Triglycerides (mmol/l) 0.45 ± 0.12 1.18 ± 0.47*
Insulin (mIU/l) 17.74 ± 0.59 49.11 ± 0.42†
HOMA-IR 4.21 ± 0.56 14.24 ± 0.86†
Body weight (g) 254 ± 33 267 ± 26
  • Physiological parameters determined in rats after 3 weeks of administration of normal or fructose-containing drinking water. Fasting triglyceride, insulin levels, and HOMA-IR were increased in fructose-treated rats after 3 weeks of administration of fructose-containing drinking water. Values shown are mean ± SE from each group of rats, respectively.

  • *P < 0.05,

  • P < 0.001 compared with rats treated with water.

This Article

  1. Diabetes vol. 59 no. 4 997-1005