Enterovirus Infection of Human β-Cells Activates Dendritic Cells and Triggers Innate Antiviral Responses: Are Enteroviruses
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CVB3-infected human islets of Langerhans (1) are being phagocytosed by human monocyte-derived DCs (2). Activated DCs (3) express ISGs, such as RIG-I and Mda5 (4), and reprogram the DCs to an antiviral state (5), which might influence the immune balance between aggression and regulation.