Combined Analyses of 20 Common Obesity Susceptibility Variants

TABLE 1

Measures of ROC curve and model performance on overweight and obesity in the population-based Inter99 using validated BMI/obesity SNPs and nongenetic risk factors separately and in combination

Trait Included factors n AUC Brier score R2
Overweight SNPs 3,244 0.53 0.25 0.019
Obesity SNPs 2,406 0.58* 0.20 0.045
Overweight Nongenetic 4,468 0.65 0.23 0.094
Obesity Nongenetic 3,278 0.67* 0.18 0.119
Overweight SNPs + nongenetic 2,679 0.64 0.23 0.106
Obesity SNPs + nongenetic 1,968 0.69* 0.17 0.168
  • To perform the ROC analysis, information regarding all 20 validated BMI/obesity variants must be available when SNPs are the included factors. Information regarding all conventional obesity risk factors must be available when nongenetic factors are the included factors, and information regarding all 20 variants plus all conventional obesity risk factors must be available when SNPs and nongenetic factors are the included factors. This explains the decreasing number of included individuals with increased number of included factors. R2, partial R2 for explained variance.

  • *graphically illustrated in Figure 3.

This Article

  1. Diabetes vol. 59 no. 7 1667-1673