Age-Period-Cohort Analysis of 1990–2003 Incidence Time Trends of Childhood Diabetes in Italy

TABLE 1

Incidence rates of type 1 diabetes among Italian children 0–14 years old in the years 1990–2003 by sex, age-group, calendar period, and geographical area of residence

Incident cases (n) Person-years at risk (n) Incidence rates per 100,000 person-years (95% CI) % Estimated completeness of ascertainment (range)
All 5,180 42,246,144 12.26 (11.93–12.60)
Boys 2,840 21,629,264 13.13 (12.66–13.62)
Girls 2,340 20,616,878 11.35 (10.90–11.82)
Age-group (years)
    0–2 479 7,984,265 6.00 (5.49–6.56)
    3–5 961 8,002,496 12.01 (11.27–12.79)
    6–8 1,118 8,259,614 13.54 (12.77–14.35)
    9–11 1,366 8,672,116 15.75 (14.94–16.61)
    12–14 1,256 9,327,652 13.47 (12.74–14.23)
Calendar period
    1990–1992 1,089 10,659,853 10.22 (9.63–10.84)
    1993–1995 1,139 9,871,152 11.54 (10.89–12.23)
    1996–1998 1,184 9,297,165 12.74 (12.03–13.48)
    1999–2001 1,091 7,836,490 13.92 (13.12–14.77)
    2002–2003 677 4,581,483 14.78 (13.7–15.93)
Birth cohort
    1975–1981 273 2,536,714 10.76 (9.56–12.12)
    1978–1984 560 4,440,171 12.61 (11.61–13.70)
    1981–1987 819 6,100,235 13.43 (12.54–14.38)
    1984–1990 1,012 7,278,051 13.90 (13.07–14.79)
    1987–1993 1,047 8,137,636 12.87 (12.11–13.67)
    1990–1996 715 6,285,553 11.38 (10.57–12.24)
    1993–1999 457 4,186,785 10.92 (9.96–11.96)
    1996–2002 226 2,385,021 9.48 (8.32–10.80)
    1999–2003 71 895,977 7.92 (6.28–10.00)
Northern Italy 945 8,006,808 11.80 (11.07–12.58)
    Turin 419 3,823,910 10.96 (9.96–12.06) 99.0 (98.2–99.4)
    Liguria 280 2,377,687 11.78 (10.47–13.24) 98.2 (96.7–99.0)
    Pavia 93 768,584 12.10 (9.87–14.83) 99.0 (97.8–99.8)
    Modena 74 613,452 12.06 (9.61–15.15) 99.3 (98.1–100)
    Trento 79 423,175 18.67 (14.97–23.27) 99.4 (98.7–100)
Central-Southern Italy 2,728 30,550,760 8.93 (8.6–9.27)
    Firenze-Prato 214 1,923,090 11.13 (9.73–12.72) 98.8 (98.0–100)
    Marche 284 2,696,075 10.53 (9.38–11.83) 99.0 (97.8–99.9)
    Lazio 678 7,522,247 9.01 (8.36–9.72) 97.0 (95.3–98.8)
    Umbria 145 1,255,832 11.55 (9.81–13.59) 99.0 (98.0–100)
    Abruzzo 115 1,196,101 9.61 (8.01–11.54) 98.1 (97.2–100)
    Campania 1,292 15,957,414 8.10 (7.67–8.55) 96.2 (94.2–98.5)
Island
    Sardinia 1,507 3,688,576 40.86 (38.84–42.97) 91.0 (89.0–96.0)

This Article

  1. Diabetes vol. 59 no. 9 2281-2287