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Table of Contents

October 2011; 60 (10)

Perspectives in Diabetes

    • Fredrik Karpe,
    • Julian R. Dickmann,
    • and Keith N. Frayn

    Fatty Acids, Obesity, and Insulin Resistance: Time for a Reevaluation

    Diabetes October 2011 60:2441-2449; doi:10.2337/db11-0425
    • Leonard A. Fahien and
    • Michael J. MacDonald

    The Complex Mechanism of Glutamate Dehydrogenase in Insulin Secretion

    Diabetes October 2011 60:2450-2454; doi:10.2337/db10-1150

Commentary

    • Nils Billestrup

    ID’ing a Novel Inhibitor of β-Cell Function, Id1

    Diabetes October 2011 60:2455-2456; doi:10.2337/db11-1084

Metabolism

    • Martin Gauster,
    • Ursula Hiden,
    • Mireille van Poppel,
    • Sasa Frank,
    • Christian Wadsack,
    • Sylvie Hauguel-de Mouzon,
    • and Gernot Desoye

    Dysregulation of Placental Endothelial Lipase in Obese Women With Gestational Diabetes Mellitus

    Diabetes October 2011 60:2457-2464; published ahead of print August 18, 2011, doi:10.2337/db10-1434
    • Dionysios V. Chartoumpekis,
    • Panos G. Ziros,
    • Agathoklis I. Psyrogiannis,
    • Athanasios G. Papavassiliou,
    • Venetsana E. Kyriazopoulou,
    • Gerasimos P. Sykiotis,
    • and Ioannis G. Habeos

    Nrf2 Represses FGF21 During Long-Term High-Fat Diet–Induced Obesity in Mice

    Diabetes October 2011 60:2465-2473; published ahead of print August 18, 2011, doi:10.2337/db11-0112

Obesity Studies

    • Yun Sok Lee,
    • Pingping Li,
    • Jin Young Huh,
    • In Jae Hwang,
    • Min Lu,
    • Jong In Kim,
    • Mira Ham,
    • Saswata Talukdar,
    • Ai Chen,
    • Wendell J. Lu,
    • Guatam K. Bandyopadhyay,
    • Reto Schwendener,
    • Jerrold Olefsky,
    • and Jae Bum Kim

    Inflammation Is Necessary for Long-Term but Not Short-Term High-Fat Diet–Induced Insulin Resistance

    Diabetes October 2011 60:2474-2483; published ahead of print September 12, 2011, doi:10.2337/db11-0194
    • Changtao Jiang,
    • Aijuan Qu,
    • Tsutomu Matsubara,
    • Tatyana Chanturiya,
    • William Jou,
    • Oksana Gavrilova,
    • Yatrik M. Shah,
    • and Frank J. Gonzalez

    Disruption of Hypoxia-Inducible Factor 1 in Adipocytes Improves Insulin Sensitivity and Decreases Adiposity in High-Fat Diet–Fed Mice

    Diabetes October 2011 60:2484-2495; published ahead of print August 26, 2011, doi:10.2337/db11-0174
    • Simonetta Lisi,
    • Olimpia Gamucci,
    • Teresa Vottari,
    • Gaia Scabia,
    • Marcella Funicello,
    • Matilde Marchi,
    • Giulia Galli,
    • Ivan Arisi,
    • Rossella Brandi,
    • Mara D’Onofrio,
    • Aldo Pinchera,
    • Ferruccio Santini,
    • and Margherita Maffei

    Obesity-Associated Hepatosteatosis and Impairment of Glucose Homeostasis Are Attenuated by Haptoglobin Deficiency

    Diabetes October 2011 60:2496-2505; published ahead of print August 26, 2011, doi:10.2337/db10-1536

Islet Studies

    • Mia C. Åkerfeldt and
    • D. Ross Laybutt

    Inhibition of Id1 Augments Insulin Secretion and Protects Against High-Fat Diet–Induced Glucose Intolerance

    Diabetes October 2011 60:2506-2514; published ahead of print September 22, 2011, doi:10.2337/db11-0083
    • Maria Sara Remedi,
    • Sophia E. Agapova,
    • Arpita K. Vyas,
    • Paul W. Hruz,
    • and Colin G. Nichols

    Acute Sulfonylurea Therapy at Disease Onset Can Cause Permanent Remission of KATP-Induced Diabetes

    Diabetes October 2011 60:2515-2522; published ahead of print August 3, 2011, doi:10.2337/db11-0538
    • Melinda T. Coughlan,
    • Felicia Y.T. Yap,
    • David C.K. Tong,
    • Sofianos Andrikopoulos,
    • Anna Gasser,
    • Vicki Thallas-Bonke,
    • Diane E. Webster,
    • Jun-ichi Miyazaki,
    • Thomas W. Kay,
    • Robyn M. Slattery,
    • David M. Kaye,
    • Brian G. Drew,
    • Bronwyn A. Kingwell,
    • Spiros Fourlanos,
    • Per-Henrik Groop,
    • Leonard C. Harrison,
    • Mikael Knip,
    • and Josephine M. Forbes

    Advanced Glycation End Products Are Direct Modulators of β-Cell Function

    Diabetes October 2011 60:2523-2532; published ahead of print September 12, 2011, doi:10.2337/db10-1033
    • Magalie A. Ravier,
    • Dorothée Daro,
    • Leticia Prates Roma,
    • Jean-Christophe Jonas,
    • Rui Cheng-Xue,
    • Frans C. Schuit,
    • and Patrick Gilon

    Mechanisms of Control of the Free Ca2+ Concentration in the Endoplasmic Reticulum of Mouse Pancreatic β-Cells: Interplay With Cell Metabolism and [Ca2+]c and Role of SERCA2b and SERCA3

    Diabetes October 2011 60:2533-2545; published ahead of print September 1, 2011, doi:10.2337/db10-1543
    • Silvia Velazquez-Garcia,
    • Shelley Valle,
    • Taylor C. Rosa,
    • Karen K. Takane,
    • Cem Demirci,
    • Juan C. Alvarez-Perez,
    • Jose M. Mellado-Gil,
    • Sara Ernst,
    • Donald K. Scott,
    • Rupangi C. Vasavada,
    • Laura C. Alonso,
    • and Adolfo Garcia-Ocaña

    Activation of Protein Kinase C-ζ in Pancreatic β-Cells In Vivo Improves Glucose Tolerance and Induces β-Cell Expansion via mTOR Activation

    Diabetes October 2011 60:2546-2559; published ahead of print September 12, 2011, doi:10.2337/db10-1783

Immunology and Transplantation

    • Liping Yu,
    • Kevan Herold,
    • Heidi Krause-Steinrauf,
    • Paula L. McGee,
    • Brian Bundy,
    • Alberto Pugliese,
    • Jeff Krischer,
    • George S. Eisenbarth,
    • and for the Type 1 Diabetes TrialNet Anti-CD20 Study Group

    Rituximab Selectively Suppresses Specific Islet Antibodies

    Diabetes October 2011 60:2560-2565; published ahead of print August 10, 2011, doi:10.2337/db11-0674
    • Dustin Blanton,
    • Zhao Han,
    • Lindsey Bierschenk,
    • M.V. Prasad Linga-Reddy,
    • Hongjie Wang,
    • Michael Clare-Salzler,
    • Michael Haller,
    • Desmond Schatz,
    • Courtney Myhr,
    • Jin-Xiong She,
    • Clive Wasserfall,
    • and Mark Atkinson

    Reduced Serum Vitamin D–Binding Protein Levels Are Associated With Type 1 Diabetes

    Diabetes October 2011 60:2566-2570; published ahead of print August 15, 2011, doi:10.2337/db11-0576
    • Daniel Nyqvist,
    • Stephan Speier,
    • Rayner Rodriguez-Diaz,
    • R. Damaris Molano,
    • Saša Lipovsek,
    • Marjan Rupnik,
    • Andrea Dicker,
    • Erwin Ilegems,
    • Elsie Zahr-Akrawi,
    • Judith Molina,
    • Maite Lopez-Cabeza,
    • Susana Villate,
    • Midhat H. Abdulreda,
    • Camillo Ricordi,
    • Alejandro Caicedo,
    • Antonello Pileggi,
    • and Per-Olof Berggren

    Donor Islet Endothelial Cells in Pancreatic Islet Revascularization

    Diabetes October 2011 60:2571-2577; published ahead of print August 26, 2011, doi:10.2337/db10-1711

Pathophysiology

    • Robert Faulhaber-Walter,
    • William Jou,
    • Diane Mizel,
    • Lingli Li,
    • Jiandi Zhang,
    • Soo Mi Kim,
    • Yuning Huang,
    • Min Chen,
    • Josephine P. Briggs,
    • Oksana Gavrilova,
    • and Jurgen B. Schnermann

    Impaired Glucose Tolerance in the Absence of Adenosine A1 Receptor Signaling

    Diabetes October 2011 60:2578-2587; published ahead of print August 10, 2011, doi:10.2337/db11-0058
    • Francesca Amati,
    • John J. Dubé,
    • Elvis Alvarez-Carnero,
    • Martin M. Edreira,
    • Peter Chomentowski,
    • Paul M. Coen,
    • Galen E. Switzer,
    • Perry E. Bickel,
    • Maja Stefanovic-Racic,
    • Frederico G.S. Toledo,
    • and Bret H. Goodpaster

    Skeletal Muscle Triglycerides, Diacylglycerols, and Ceramides in Insulin Resistance: Another Paradox in Endurance-Trained Athletes?

    Diabetes October 2011 60:2588-2597; published ahead of print August 26, 2011, doi:10.2337/db10-1221
    • Amal Ait-Omar,
    • Milena Monteiro-Sepulveda,
    • Christine Poitou,
    • Maude Le Gall,
    • Aurélie Cotillard,
    • Jules Gilet,
    • Kevin Garbin,
    • Anne Houllier,
    • Danièle Château,
    • Amélie Lacombe,
    • Nicolas Veyrie,
    • Danielle Hugol,
    • Joan Tordjman,
    • Christophe Magnan,
    • Patricia Serradas,
    • Karine Clément,
    • Armelle Leturque,
    • and Edith Brot-Laroche

    GLUT2 Accumulation in Enterocyte Apical and Intracellular Membranes: A Study in Morbidly Obese Human Subjects and ob/ob and High Fat–Fed Mice

    Diabetes October 2011 60:2598-2607; published ahead of print August 18, 2011, doi:10.2337/db10-1740

Pharmacology and Therapeutics

    • Swenja Schuhmacher,
    • Matthias Oelze,
    • Franziska Bollmann,
    • Hartmut Kleinert,
    • Christian Otto,
    • Tjebo Heeren,
    • Sebastian Steven,
    • Michael Hausding,
    • Maike Knorr,
    • Andrea Pautz,
    • Kurt Reifenberg,
    • Eberhard Schulz,
    • Tommaso Gori,
    • Philip Wenzel,
    • Thomas Münzel,
    • and Andreas Daiber

    Vascular Dysfunction in Experimental Diabetes Is Improved by Pentaerithrityl Tetranitrate but Not Isosorbide-5-Mononitrate Therapy

    Diabetes October 2011 60:2608-2616; published ahead of print August 15, 2011, doi:10.2337/db10-1395
    • Cecilia Morgantini,
    • Andrea Natali,
    • Beatrice Boldrini,
    • Satoshi Imaizumi,
    • Mohamad Navab,
    • Alan M. Fogelman,
    • Ele Ferrannini,
    • and Srinivasa T. Reddy

    Anti-inflammatory and Antioxidant Properties of HDLs Are Impaired in Type 2 Diabetes

    Diabetes October 2011 60:2617-2623; published ahead of print August 18, 2011, doi:10.2337/db11-0378

Genetics

    • Rona J. Strawbridge,
    • Josée Dupuis,
    • Inga Prokopenko,
    • Adam Barker,
    • Emma Ahlqvist,
    • Denis Rybin,
    • John R. Petrie,
    • Mary E. Travers,
    • Nabila Bouatia-Naji,
    • Antigone S. Dimas,
    • Alexandra Nica,
    • Eleanor Wheeler,
    • Han Chen,
    • Benjamin F. Voight,
    • Jalal Taneera,
    • Stavroula Kanoni,
    • John F. Peden,
    • Fabiola Turrini,
    • Stefan Gustafsson,
    • Carina Zabena,
    • Peter Almgren,
    • David J.P. Barker,
    • Daniel Barnes,
    • Elaine M. Dennison,
    • Johan G. Eriksson,
    • Per Eriksson,
    • Elodie Eury,
    • Lasse Folkersen,
    • Caroline S. Fox,
    • Timothy M. Frayling,
    • Anuj Goel,
    • Harvest F. Gu,
    • Momoko Horikoshi,
    • Bo Isomaa,
    • Anne U. Jackson,
    • Karen A. Jameson,
    • Eero Kajantie,
    • Julie Kerr-Conte,
    • Teemu Kuulasmaa,
    • Johanna Kuusisto,
    • Ruth J.F. Loos,
    • Jian'an Luan,
    • Konstantinos Makrilakis,
    • Alisa K. Manning,
    • María Teresa Martínez-Larrad,
    • Narisu Narisu,
    • Maria Nastase Mannila,
    • John Öhrvik,
    • Clive Osmond,
    • Laura Pascoe,
    • Felicity Payne,
    • Avan A. Sayer,
    • Bengt Sennblad,
    • Angela Silveira,
    • Alena Stančáková,
    • Kathy Stirrups,
    • Amy J. Swift,
    • Ann-Christine Syvänen,
    • Tiinamaija Tuomi,
    • Ferdinand M. van 't Hooft,
    • Mark Walker,
    • Michael N. Weedon,
    • Weijia Xie,
    • Björn Zethelius,
    • the DIAGRAM Consortium,
    • the GIANT Consortium,
    • the MuTHER Consortium,
    • the CARDIoGRAM Consortium,
    • the C4D Consortium,
    • Halit Ongen,
    • Anders Mälarstig,
    • Jemma C. Hopewell,
    • Danish Saleheen,
    • John Chambers,
    • Sarah Parish,
    • John Danesh,
    • Jaspal Kooner,
    • Claes-Göran Östenson,
    • Lars Lind,
    • Cyrus C. Cooper,
    • Manuel Serrano-Ríos,
    • Ele Ferrannini,
    • Tom J. Forsen,
    • Robert Clarke,
    • Maria Grazia Franzosi,
    • Udo Seedorf,
    • Hugh Watkins,
    • Philippe Froguel,
    • Paul Johnson,
    • Panos Deloukas,
    • Francis S. Collins,
    • Markku Laakso,
    • Emmanouil T. Dermitzakis,
    • Michael Boehnke,
    • Mark I. McCarthy,
    • Nicholas J. Wareham,
    • Leif Groop,
    • François Pattou,
    • Anna L. Gloyn,
    • George V. Dedoussis,
    • Valeriya Lyssenko,
    • James B. Meigs,
    • Inês Barroso,
    • Richard M. Watanabe,
    • Erik Ingelsson,
    • Claudia Langenberg,
    • Anders Hamsten,
    • and Jose C. Florez

    Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes

    Diabetes October 2011 60:2624-2634; published ahead of print August 26, 2011, doi:10.2337/db11-0415
    • Joanna M.M. Howson,
    • Helen Stevens,
    • Deborah J. Smyth,
    • Neil M. Walker,
    • Kyla A. Chandler,
    • Polly J. Bingley,
    • and John A. Todd

    Evidence That HLA Class I and II Associations With Type 1 Diabetes, Autoantibodies to GAD and Autoantibodies to IA-2, Are Distinct

    Diabetes October 2011 60:2635-2644; published ahead of print August 10, 2011, doi:10.2337/db11-0131
    • Joanna M.M. Howson,
    • Silke Rosinger,
    • Deborah J. Smyth,
    • Bernhard O. Boehm,
    • the ADBW-END Study Group,
    • and John A. Todd

    Genetic Analysis of Adult-Onset Autoimmune Diabetes

    Diabetes October 2011 60:2645-2653; published ahead of print August 26, 2011, doi:10.2337/db11-0364
    • Alain Gautier,
    • Ronan Roussel,
    • Céline Lange,
    • Xavier Piguel,
    • Stéphane Cauchi,
    • Sylviane Vol,
    • Philippe Froguel,
    • Beverley Balkau,
    • and Fabrice Bonnet

    Effects of Genetic Susceptibility for Type 2 Diabetes on the Evolution of Glucose Homeostasis Traits Before and After Diabetes Diagnosis: Data From the D.E.S.I.R. Study

    Diabetes October 2011 60:2654-2663; published ahead of print September 12, 2011, doi:10.2337/db10-1442

Erratum

  • Erratum

    Diabetes October 2011 60:2664; doi:10.2337/db11-er10
    Free Article

Issues and Events

  • Issues and Events

    Diabetes October 2011 60:2665; doi:10.2337/db11-ie10
    Free Article
|

This Issue

October 2011; 60 (10)
Cover
  1. Perspectives in Diabetes
  2. Commentary
  3. Metabolism
  4. Obesity Studies
  5. Islet Studies
  6. Immunology and Transplantation
  7. Pathophysiology
  8. Pharmacology and Therapeutics
  9. Genetics
  10. Erratum
  11. Issues and Events

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