Fatty Acids, Obesity, and Insulin Resistance: Time for a Reevaluation

TABLE 1

Univariate relationships (Spearman’s rank correlation coefficient) with plasma NEFA concentrations in the Oxford BioBank

NEFA with BMI Fat mass WHR Insulin HOMA-IR TG 3-OHB CRP SBP DBP
Males
 rs 0.057 0.031 0.034 −0.028 −0.025 0.017 0.570 0.045 0.157 0.050
 P 0.094 0.362 0.323 0.409 0.466 0.616 <0.001 0.264 <0.001 0.141
 n 859 859 856 859 859 859 857 627 859 859
Females
 rs 0.091 0.081 0.043 0.086 0.094 0.142 0.654 0.116 0.132 0.126
 P 0.007 0.017 0.209 0.012 0.006 < 0.001 <0.001 0.004 <0.001 <0.001
 n 861 861 859 861 861 861 861 633 861 861
  • Samples were from 1,720 healthy individuals, median age 41 (range 2–53) years, median BMI 25 (range 15–48) kg/m2. 3-OHB, 3-hydroxybutyrate; DBP, diastolic blood pressure; HOMA-IR, homeostatic model assessment of insulin resistance; SBP, systolic blood pressure; WHR, waist-to-hip ratio.

This Article

  1. Diabetes vol. 60 no. 10 2441-2449