Subcutaneous Adipose Tissue Macrophage Infiltration Is Associated With Hepatic and Visceral Fat Deposition, Hyperinsulinemia, and Stimulation of NF-κB Stress Pathway

TABLE 1

Anthropometric, body composition, SI, and plasma parameters stratified by adipose tissue inflammatory status

CLS− CLS+ P value
n 20 16
Number of CLS (per 400 adipocyte) 0 ± 0 12.9 ± 17.9 0.002
Age (years) 21.6 ± 2.2 21.1 ± 2.4 NS
Sex (men/women) 8/12 8/8 NS
Ethnicity (Hispanic/African American) 10/10 10/6 NS
Body composition
 BMI (kg/m2) 35.1 ± 3.3 36.3 ± 4.1 NS
 Total fat (%) 37.7 ± 7.4 37.3 ± 6.3 NS
 SAT (L) 16.0 ± 4.9 17.3 ± 3.9 NS
 VAT (L) 2.6 ± 1.6 3.7 ± 1.3 0.04
 HFF (%) 5.8 ± 4.4 9.9 ± 7.3 0.03
SI
 Fasting glucose (mg/dL) 86.8 ± 5.3 94.4 ± 9.3 0.005
 Fasting insulin (mU/mL) 9.7 ± 6.6 20.9 ± 10.6 <0.001
 HOMA-IR 2.0 ± 1.4 4.4 ± 2.2 <0.001
 HOMA–β-cell 191.4 ± 125.4 399 ± 301 0.01
 Acute insulin response (mU/mL × 10 min) 1,320 ± 912 1,116 ± 796 NS
 SI (×10−4 min−1/mU/mL) 1.9 ± 0.7 1.3 ± 0.9 NS
 DI (×10−4 min−1) 2,024 ± 829 1,559 ± 984 0.03
Lipid metabolism
 FFAs (mmol/L) 0.87 ± 0.19 0.83 ± 0.15 NS
 TGs (mg/dL) 113 ± 59 102 ± 48 NS
 Cholesterol (mg/dL)
  Total 155 ± 31 158 ± 35 NS
  LDL 81 ± 26 94 ± 39 NS
  HDL 50 ± 11 43 ± 13 0.09
Inflammation
 MCP-1 (pg/mL) 349 ± 182 379 ± 97 NS
 IL-8 (pg/mL) 9.7 ± 3.3 11.4 ± 3.2 NS
 TNF-α (pg/mL) 16.2 ± 5.8 20.8 ± 4.8 0.01
 HGF (ng/mL) 2.1 ± 0.8 2.1 ± 0.8 NS
 PAI-1 (ng/mL) 104 ± 44 121 ± 43 NS
 hs-CRP (mg/L) 7.7 ± 16.2 6.7 ± 8.3 NS
 Leptin (ng/mL) 45 ± 22 51 ± 28 NS
 Adiponectin (mg/mL) 17 ± 6 14 ± 5 NS
  • Data are means ± SD. HGF, hepatocyte growth factor; hs-CRP, high-sensitivity C-reactive protein; NS, not significant; PAI-1, plasminogen activator inhibitor 1.

This Article

  1. Diabetes vol. 60 no. 11 2802-2809