Subcutaneous Adipose Tissue Macrophage Infiltration Is Associated With Hepatic and Visceral Fat Deposition, Hyperinsulinemia, and Stimulation of NF-κB Stress Pathway

TABLE 2

Top 15 up- and downregulated genes in CLS+ compared with CLS− individuals

Upregulated in CLS+ individuals Downregulated in CLS+ individuals
Unigene official gene symbol Gene name P value Fold change Unigene official gene symbol Gene name P value Fold change
MMP9 matrix metallopeptidase 9 0.0004 +4.8 KRT15 keratin 15 0.04 −2.2
SPP1 secreted phosphoprotein 1 0.01 +3.2 CIDEA cell death-inducing DFFA-like effector a 0.04 −1.9
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 0.0001 +2.7 COBL cordon-bleu homolog (mouse) 0.01 −1.9
PLA2G7 platelet-activating factor acetylhydrolase, plasma 0.005 +2.6 COL6A6 collagen, type VI, α-6 0.004 −1.8
IFI30 interferon, γ-inducible protein 30 0.003 +2.2 CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 0.04 −1.8
PLA2G2A phospholipase A2, group IIA 0.003 +2.1 S100P S100 calcium binding protein P 0.02 −1.6
LBP lipopolysaccharide binding protein 0.004 +2.1 GSDMB gasdermin B 0.02 −1.6
ITGAX integrin, α-X 0.006 +2.0 CISH cytokine inducible SH2-containing protein 0.02 −1.6
IL1RN IL-1 receptor antagonist 0.03 +2.0 ALDH3B2 aldehyde dehydrogenase 3 family, member B2 0.04 −1.6
CLIC6 chloride intracellular channel 6 0.03 +2.0 ADH1A alcohol dehydrogenase 1A (class I), α-polypeptide 0.006 −1.6
CHI3L2 chitinase 3-like 2 0.001 +2.0 IRS1 insulin receptor substrate 1 0.02 −1.6
HMOX1 heme oxygenase 1 0.0001 +2.0 FHOD3 formin homology 2 domain containing 3 0.02 −1.6
ACP5 acid phosphatase 5 0.007 +2.0 IRS2 insulin receptor substrate 2 0.01 −1.5
PRND prion protein 2 0.005 +1.9 RAP1GAP RAP1 GTPase activating protein 0.03 −1.5
HP haptoglobin 0.009 +1.8 ADH1B alcohol dehydrogenase 1B (class I), β-polypeptide 0.02 −1.5
  • Positive fold change, upregulated in individuals with CLS (CLS+); negative fold change, downregulated in individuals with CLS (CLS−).

This Article

  1. Diabetes vol. 60 no. 11 2802-2809