Subcutaneous Adipose Tissue Macrophage Infiltration Is Associated With Hepatic and Visceral Fat Deposition, Hyperinsulinemia, and Stimulation of NF-κB Stress Pathway

TABLE 3

Differentially regulated pathways between CLS+ and CLS− individuals

Canonical pathway No. of genes P value Symbol
Liver X receptor/retinoid X receptor activation 9 4.20 E-05 CD14, CCL2, TNFRSF11B, APOC1, MSR1, MMP9, NGFR, IL1RN, LBP
Hepatic cholestasis 12 6.69 E-05 CD14, CYP27A1, ABCC3, SLCO3A1, TNFRSF11B, IRAK1, ESR1, NGFR, RARA, IL1RN, LBP, HSD3B7
Bile acid biosynthesis 7 9.26 E-05 CYP27A1, ALDH1A3, ADHFE1, DHRS9, ADH1A, ADH1B, HSD3B7
Metabolism of xenobiotics by cytochrome P450 10 1.17 E-04 AKR1C2, ALDH1A3, CYP2F1, ALDH3B2 (includes EG:222), ADHFE1, CYP2C9, CYP2S1, DHRS9, ADH1A, ADH1B
Atherosclerosis signaling 10 1.4 E-04 PDGFA, CXCR4, CCL2, ITGB2, ALOX5, MSR1, MMP9, PLA2G2A, TNFRSF12A, IL1RN
Hepatic fibrosis/hepatic stellate cell activation 11 2.7 E-04 CD14, PDGFA, TIMP1, CCL2, EDNRA, TNFRSF11B, AGTR1, MMP9, NGFR, EGFR, LBP
IL-10 signaling 7 6.6 E-04 CD14, FCGR2B, CCR1, IL1RN, LBP, FCGR2A, HMOX1
Fatty acid metabolism 9 9.4 E-04 ALDH1A3, CYP2F1, ADHFE1, AUH, CYP2C9, CYP2S1, DHRS9, ADH1A, ADH1B
Complement system 5 1.2 E-03 C5AR1, C1QC, C2, C3AR1, CFB
Fcγ receptor-mediated phagocytosis in macrophages and monocytes 8 1.71 E-03 LYN, FCGR1A, PLD3, FGR, SYK, FCGR2A, WAS, HMOX1
Lipopolysaccharide/IL-1-mediated inhibition of retinoid X receptor function 12 2.1 E-03 CD14, ABCC3, IL4I1, TNFRSF11B, ALDH1A3, APOC1, IRAK1, ALDH3B2 (includes EG:222), CYP2C9, NGFR, RARA, LBP
Acute phase response signaling 11 2.8 E-03 TNFRSF11B, IRAK1, SERPINA3, C2, NGFR, HAMP, IL1RN, HP, LBP, HMOX1, CFB
Dendritic cell maturation 10 2.9 E-03 FCGR2B, CD86, TNFRSF11B, TYROBP, FCGR1A, NGFR, IL1RN, TREM2, FCGR2A, FCGR1B
IL-9 signaling 4 6.8 E-03 IRS1, BCL3, IRS2, CISH
PPAR signaling 5 1.5 E-02 PDGFA, TNFRSF11B, CITED2, NGFR, IL1RN, PPARGC1A
IL-8 signaling 9 2.01 E-02 ITGB2, ITGAX, IRAK1, MMP9, PLD3, GNAI1, ANGPT2, EGFR, HMOX1
IL-6 signaling 6 2.07 E-02 CD14, TNFRSF11B, NGFR, IL1RN, LBP, TNFAIP6
Role of macrophages, fibroblasts, and endothelial cells in rheumatoid arthritis 13 3.6 E-02 PDGFA, F2RL1, TNFRSF11B, FCGR1A, CFB, C5AR1, CCL2, FZD2, IRAK1, NGFR, HP, IL1RN, TNFSF13B
Type 2 diabetes signaling 1.26E00 3.8E-02 IRS1, TNFRSF11B, IRS2, PKM2, NGFR, SMPD1
  • PPAR, peroxisome proliferator–activated receptor.

This Article

  1. Diabetes vol. 60 no. 11 2802-2809