Prospectively Determined Impact of Type 1 Diabetes on Brain Volume During Development

TABLE 2

Demographic and clinical variables for T1DM subgroups

No hypo Any hypo HbA1c (%)
<7.5 7.5–8.9 ≥9
n 49 19 15 44 16
Age at Time 1 (years) 12.8 (2.7) 11.8 (3.1) 13.0 (3.6) 12.2 (2.7) 12.9 (2.6)
Male/female (% male) 31/18 (63) 13/6 (68) 11/4 (73) 29/15 (66) 8/8 (50)
Right handed/other (% right handed) 43/6 (88) 16/3 (84) 13/2 (87) 38/6 (86) 14/2 (88)
Parent education (years) 14.6 (2.2) 15.6 (1.9) 15.4 (2.3) 15.0 (2.1) 14.5 (1.9)
Age of diabetes onset (years) 7.0 (3.6) 6.8 (2.9) 6.8 (3.0) 6.7 (3.5) 7.7 (3.4)
Severe hypoglycemic episodes during 2-year follow-up 0 2.3 (0.6) 0.2 (0.4) 0.8 (2.7) 0.5 (0.7)
Participants with any severe hypoglycemic episodes during 2-year follow-up 0 (0) 19 (100) 3 (20) 11 (25) 5 (31)
Mean HbA1c during 2-year follow-up 8.5 (1.4) 8.5 (1.3) 7.1 (0.4) 8.2 (0.4) 10.8 (1.2)
Participants with ketoacidosis during 2-year follow-up 5 (10) 3 (16) 1 (6) 6 (14) 3 (19)
  • Data are means (SD) and n (%) unless otherwise indicated. Hypo, hypoglycemia.

This Article

  1. Diabetes vol. 60 no. 11 3006-3014