Prospectively Determined Impact of Type 1 Diabetes on Brain Volume During Development

TABLE 4

Summary of whole brain and voxel-wise analyses and results by group and variable

Significant effects of diagnosis or exposure
T1DM vs. NDC
 Whole brain
  Gray None
  White None
 Voxel-wise
  Gray None
  White None
Hyperglycemia
 Whole brain
  Gray Higher HbA1c → greater decrease over time
  White None
 Voxel-wise
  Gray None
  White None
Severe hypoglycemia
 Whole brain
  Gray None
  White None
 Voxel-wise
  Gray None
  White Any severe hypoglycemia → greater decrease in occipital/parietal region over time
Mild hypoglycemia
 Whole brain
  Gray None
  White None
 Voxel-wise
  Gray None
  White None

This Article

  1. Diabetes vol. 60 no. 11 3006-3014