Decreased IRS2 and TIMP3 Expression in Monocytes From Offspring of Type 2 Diabetic Patients Is Correlated With Insulin Resistance and Increased Intima-Media Thickness

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

FIG. 3.
FIG. 3.

TIMP3 and ADAM17 pathway in monocytes from FDRs. A: TIMP3 expression is higher in insulin-sensitive compared with insulin-resistant FDR subjects (*P < 0.05 for LOW M [n = 14] compared with HIGH M [n = 13] by ANOVA with Bonferroni multiple comparison tests). B: ADAM17 activity is significantly higher in monocyte extracts from insulin-resistant (black bar; n = 14) compared with insulin-sensitive (white bar; n = 13) FDR subjects (*P < 0.05 by Student t test). C: mRNA expression of TIMP3 in monocytes from FDRs of type 2 diabetic subjects is negatively correlated with subclinical atherosclerosis. D: Expression of TIMP3 in monocytes from FDRs of type 2 diabetic subjects is positively correlated with IRS2 mRNA levels. E: Expression of TIMP3 in monocytes from FDRs of type 2 diabetic subjects is reduced according to IRS2 mRNA expressed in tertiles. F: Soluble IL-6 receptor (rec), a marker of increased ectodomain shedding, is significantly higher in subjects with lowest IRS2 mRNA expression levels. *P < 0.05 for LOW IRS2 (n = 14) compared with HIGH IRS2 (n = 14) by Student t test. a.u., arbitrary unit.

This Article

  1. Diabetes vol. 60 no. 12 3265-3270