The Same Chromosome 9p21.3 Locus Is Associated With Type 2 Diabetes and Coronary Artery Disease in a Chinese Han Population
- Xiang Cheng1,2,3,
- Lisong Shi2,3,
- Shaofang Nie1,3,
- Fan Wang2,3,
- Xiuchun Li2,3,
- Chengqi Xu2,3,
- Pengyun Wang2,3,
- Baofeng Yang4,
- Qingxian Li6,
- Zhenwei Pan4,
- Yue Li5,
- Hao Xia7,
- Chenhong Zheng8,
- Yuhe Ke8,
- Yanxia Wu8,
- Tingting Tang1,3,
- Xinxin Yan1,3,
- Yan Yang1,3,
- Ni Xia1,3,
- Rui Yao1,3,
- Binbin Wang9,
- Xu Ma9,
- Qiutang Zeng1,3,
- Xin Tu2,3,
- Yuhua Liao1,3 and
- Qing K. Wang2,3
- 1Institute of Cardiology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- 2Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, China
- 3Cardio-X Institute, Huazhong University of Science and Technology, Wuhan, China
- 4Department of Pharmacology, Harbin Medical University, Harbin, China
- 5Department of Cardiology, the First Affiliated Hospital of Harbin Medical University, Harbin, China
- 6Department of Cardiology, Jining Medical College Affiliated Hospital, Jining, China
- 7Renmin Hospital of Wuhan University, Wuhan, China
- 8Wuhan No.1 Hospital, Wuhan, China
- 9Research Institute of the National Population and Family Planning Commission, Beijing, China
- Corresponding authors: Xin Tu, xtu{at}mail.hust.edu.cn; Yuhua Liao, liaoyh27{at}163.com; or Qing K. Wang, qkwang{at}mail.hust.edu.cn.
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X.C., L.S., and S.N. contributed equally to this work.
Abstract
OBJECTIVE Recent genome-wide association studies (GWAS) revealed that a 9p21.3 locus was associated with type 2 diabetes. In this study, we carried out a large-scale case-control study in the GeneID Chinese Han population to 1) further replicate the association of 9p21.3 type 2 diabetes GWAS single nucleotide polymorphisms (SNPs) and 2) assess the association of these SNPs with coronary artery disease.
RESEARCH DESIGN AND METHODS Three SNPs (rs2383208, rs10811661, and rs10757283) were genotyped in two GeneID cohorts of 3,167 Chinese Han individuals. Case-control association design was used to determine the association of the SNPs with type 2 diabetes and coronary artery disease. Gensini scores were calculated in the coronary artery disease subjects and were tested for association with the variants. Multivariate logistic regressions were performed on association studies.
RESULTS The association between two of the three SNPs and type 2 diabetes was replicated in the GeneID population (rs2383208, P = 0.936; rs10811661-T, P = 0.02, odds ratio [OR] = 1.23; rs10757283-C, P = 0.003, OR = 1.30). The same two SNPs also contributed to the risk of coronary artery disease (CAD) (rs10811661-T, P = 0.002, OR = 1.19; rs10757283-C, P = 0.003, OR = 1.18). In addition, rs10757283 was associated with severity of coronary atherosclerosis estimated by the Gensini scoring system (risk allele C, quantitative-trait regression adjusted P = 0.002).
CONCLUSIONS For the first time to our knowledge, our results indicated that the same 9p21.3 locus, represented by SNPs rs10811661 and rs10757283, contributed to the risk of type 2 diabetes and coronary artery disease in our GeneID Chinese Han population.
Footnotes
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This article contains Supplementary Data online at http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db10-0185/-/DC1.
- Received February 6, 2010.
- Accepted October 29, 2010.
- © 2011 by the American Diabetes Association.
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