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Table of Contents

March 2011; 60 (3)

Editorial

    • Carla Greenbaum and
    • Mark A. Atkinson

    Persistence is the Twin Sister of Excellence: An Important Lesson for Attempts to Prevent and Reverse Type 1 Diabetes

    Diabetes March 2011 60:693-694; doi:10.2337/db10-1810

Commentaries

    • Ele Ferrannini

    Learning From Glycosuria

    Diabetes March 2011 60:695-696; doi:10.2337/db10-1667
    • Lars Groth Grunnet and
    • Thomas Mandrup-Poulsen

    Cytokines and Type 1 Diabetes: A Numbers Game

    Diabetes March 2011 60:697-699; doi:10.2337/db10-1782

Metabolism

    • Hua V. Lin,
    • Hongxia Ren,
    • Varman T. Samuel,
    • Hui-Young Lee,
    • Taylor Y. Lu,
    • Gerald I. Shulman,
    • and Domenico Accili

    Diabetes in Mice With Selective Impairment of Insulin Action in Glut4-Expressing Tissues

    Diabetes March 2011 60:700-709; published ahead of print January 24, 2011, doi:10.2337/db10-1056
    • Jae Geun Kim,
    • Byong Seo Park,
    • Chang Ho Yun,
    • Hyun Jun Kim,
    • Sang Soo Kang,
    • Angela Valentina D’Elia,
    • Giuseppe Damante,
    • Ki-Up Lee,
    • Jeong Woo Park,
    • Eun Sook Kim,
    • Il Seong Namgoong,
    • Young Il Kim,
    • and Byung Ju Lee

    Thyroid Transcription Factor‐1 Regulates Feeding Behavior via Melanocortin Pathway in the Hypothalamus

    Diabetes March 2011 60:710-719; published ahead of print January 31, 2011, doi:10.2337/db10-0183
    • Roland H. Stimson,
    • Ruth Andrew,
    • Norma C. McAvoy,
    • Dhiraj Tripathi,
    • Peter C. Hayes,
    • and Brian R. Walker

    Increased Whole-Body and Sustained Liver Cortisol Regeneration by 11β-Hydroxysteroid Dehydrogenase Type 1 in Obese Men With Type 2 Diabetes Provides a Target for Enzyme Inhibition

    Diabetes March 2011 60:720-725; published ahead of print January 24, 2011, doi:10.2337/db10-0726
    • Chia Lin Chang,
    • James J. Cai,
    • Po Jen Cheng,
    • Ho Yen Chueh,
    • and Sheau Yu Teddy Hsu

    Identification of Metabolic Modifiers That Underlie Phenotypic Variations in Energy-Balance Regulation

    Diabetes March 2011 60:726-734; published ahead of print February 7, 2011, doi:10.2337/db10-1331
    • Marc Claret,
    • Mark A. Smith,
    • Claude Knauf,
    • Hind Al-Qassab,
    • Angela Woods,
    • Amanda Heslegrave,
    • Kaisa Piipari,
    • Julian J. Emmanuel,
    • André Colom,
    • Philippe Valet,
    • Patrice D. Cani,
    • Ghazala Begum,
    • Anne White,
    • Phillip Mucket,
    • Marco Peters,
    • Keiko Mizuno,
    • Rachel L. Batterham,
    • K. Peter Giese,
    • Alan Ashworth,
    • Remy Burcelin,
    • Michael L. Ashford,
    • David Carling,
    • and Dominic J. Withers

    Deletion of Lkb1 in Pro-Opiomelanocortin Neurons Impairs Peripheral Glucose Homeostasis in Mice

    Diabetes March 2011 60:735-745; published ahead of print January 24, 2011, doi:10.2337/db10-1055
    • Fei Xiao,
    • Zhiying Huang,
    • Houkai Li,
    • Junjie Yu,
    • Chunxia Wang,
    • Shanghai Chen,
    • Qingshu Meng,
    • Ying Cheng,
    • Xiang Gao,
    • Jia Li,
    • Yong Liu,
    • and Feifan Guo

    Leucine Deprivation Increases Hepatic Insulin Sensitivity via GCN2/mTOR/S6K1 and AMPK Pathways

    Diabetes March 2011 60:746-756; published ahead of print January 31, 2011, doi:10.2337/db10-1246
    • Nabila Aboulaich,
    • Patricia C. Chui,
    • John M. Asara,
    • Jeffrey S. Flier,
    • and Eleftheria Maratos-Flier

    Polymerase I and Transcript Release Factor Regulates Lipolysis via a Phosphorylation-Dependent Mechanism

    Diabetes March 2011 60:757-765; published ahead of print January 31, 2011, doi:10.2337/db10-0744
    • Roger W. Hunter,
    • Jonas T. Treebak,
    • Jørgen F.P. Wojtaszewski,
    • and Kei Sakamoto

    Molecular Mechanism by Which AMP-Activated Protein Kinase Activation Promotes Glycogen Accumulation in Muscle

    Diabetes March 2011 60:766-774; published ahead of print January 31, 2011, doi:10.2337/db10-1148
    • Hyeong-Kyu Park,
    • Mohammed Qatanani,
    • Erika R. Briggs,
    • Rexford S. Ahima,
    • and Mitchell A. Lazar

    Inflammatory Induction of Human Resistin Causes Insulin Resistance in Endotoxemic Mice

    Diabetes March 2011 60:775-783; published ahead of print January 31, 2011, doi:10.2337/db10-1416

Obesity Studies

    • Alexandre G. Oliveira,
    • Bruno M. Carvalho,
    • Natália Tobar,
    • Eduardo R. Ropelle,
    • José R. Pauli,
    • Renata A. Bagarolli,
    • Dioze Guadagnini,
    • José B.C. Carvalheira,
    • and Mario J.A. Saad

    Physical Exercise Reduces Circulating Lipopolysaccharide and TLR4 Activation and Improves Insulin Signaling in Tissues of DIO Rats

    Diabetes March 2011 60:784-796; published ahead of print January 31, 2011, doi:10.2337/db09-1907
    • Xavier Prieur,
    • Crystal Y.L. Mok,
    • Vidya R. Velagapudi,
    • Vanessa Núñez,
    • Lucía Fuentes,
    • David Montaner,
    • Ko Ishikawa,
    • Alberto Camacho,
    • Nuria Barbarroja,
    • Stephen O’Rahilly,
    • Jaswinder K. Sethi,
    • Joaquin Dopazo,
    • Matej Orešič,
    • Mercedes Ricote,
    • and Antonio Vidal-Puig

    Differential Lipid Partitioning Between Adipocytes and Tissue Macrophages Modulates Macrophage Lipotoxicity and M2/M1 Polarization in Obese Mice

    Diabetes March 2011 60:797-809; published ahead of print January 24, 2011, doi:10.2337/db10-0705
    • Keval Chandarana,
    • Cigdem Gelegen,
    • Efthimia Karra,
    • Agharul I. Choudhury,
    • Megan E. Drew,
    • Veronique Fauveau,
    • Benoit Viollet,
    • Fabrizio Andreelli,
    • Dominic J. Withers,
    • and Rachel L. Batterham

    Diet and Gastrointestinal Bypass–Induced Weight Loss: The Roles of Ghrelin and Peptide YY

    Diabetes March 2011 60:810-818; published ahead of print February 3, 2011, doi:10.2337/db10-0566
    • Masayuki Ichioka,
    • Takayoshi Suganami,
    • Naoto Tsuda,
    • Ibuki Shirakawa,
    • Yoichiro Hirata,
    • Noriko Satoh-Asahara,
    • Yuri Shimoda,
    • Miyako Tanaka,
    • Misa Kim-Saijo,
    • Yoshihiro Miyamoto,
    • Yasutomi Kamei,
    • Masataka Sata,
    • and Yoshihiro Ogawa

    Increased Expression of Macrophage-Inducible C-type Lectin in Adipose Tissue of Obese Mice and Humans

    Diabetes March 2011 60:819-826; published ahead of print January 31, 2011, doi:10.2337/db10-0864

Islet Studies

    • Yanyun Gu,
    • Jill Lindner,
    • Anil Kumar,
    • Weiping Yuan,
    • and Mark A. Magnuson

    Rictor/mTORC2 Is Essential for Maintaining a Balance Between β-Cell Proliferation and Cell Size

    Diabetes March 2011 60:827-837; published ahead of print January 24, 2011, doi:10.2337/db10-1194
    • Xiao-Qing Dai,
    • Greg Plummer,
    • Marina Casimir,
    • Youhou Kang,
    • Catherine Hajmrle,
    • Herbert Y. Gaisano,
    • Jocelyn E. Manning Fox,
    • and Patrick E. MacDonald

    SUMOylation Regulates Insulin Exocytosis Downstream of Secretory Granule Docking in Rodents and Humans

    Diabetes March 2011 60:838-847; published ahead of print January 24, 2011, doi:10.2337/db10-0440
    • Yoshifumi Saisho,
    • Erica Manesso,
    • Alexandra E. Butler,
    • Ryan Galasso,
    • Kylie Kavanagh,
    • Mickey Flynn,
    • Li Zhang,
    • Paige Clark,
    • Tatyana Gurlo,
    • Gianna M. Toffolo,
    • Claudio Cobelli,
    • Janice D. Wagner,
    • and Peter C. Butler

    Ongoing β-Cell Turnover in Adult Nonhuman Primates Is Not Adaptively Increased in Streptozotocin-Induced Diabetes

    Diabetes March 2011 60:848-856; published ahead of print January 26, 2011, doi:10.2337/db09-1368

Immunology and Transplantation

    • Huilian Qin,
    • I-Fang Lee,
    • Constadina Panagiotopoulos,
    • Xiaoxia Wang,
    • Alvina D. Chu,
    • Paul J. Utz,
    • John J. Priatel,
    • and Rusung Tan

    Natural Killer Cells From Children With Type 1 Diabetes Have Defects in NKG2D-Dependent Function and Signaling

    Diabetes March 2011 60:857-866; published ahead of print January 26, 2011, doi:10.2337/db09-1706
    • Helen M. McGuire,
    • Stacey Walters,
    • Alexis Vogelzang,
    • Carol M.Y. Lee,
    • Kylie E. Webster,
    • Jonathan Sprent,
    • Daniel Christ,
    • Shane Grey,
    • and Cecile King

    Interleukin-21 Is Critically Required in Autoimmune and Allogeneic Responses to Islet Tissue in Murine Models

    Diabetes March 2011 60:867-875; doi:10.2337/db10-1157
    • Eitan M. Akirav,
    • Maria-Teresa Baquero,
    • Lynn W. Opare-Addo,
    • Michael Akirav,
    • Eva Galvan,
    • Jake A. Kushner,
    • David L. Rimm,
    • and Kevan C. Herold

    Glucose and Inflammation Control Islet Vascular Density and β-Cell Function in NOD Mice: Control of Islet Vasculature and Vascular Endothelial Growth Factor by Glucose

    Diabetes March 2011 60:876-883; published ahead of print February 9, 2011, doi:10.2337/db10-0793
    • Kaoru Aida,
    • Yoriko Nishida,
    • Shoichiro Tanaka,
    • Taro Maruyama,
    • Akira Shimada,
    • Takuya Awata,
    • Masako Suzuki,
    • Hiroki Shimura,
    • Soichi Takizawa,
    • Masashi Ichijo,
    • Daiichiro Akiyama,
    • Fumihiko Furuya,
    • Akio Kawaguchi,
    • Masahiro Kaneshige,
    • Jun Itakura,
    • Hideki Fujii,
    • Toyoshi Endo,
    • and Tetsuro Kobayashi

    RIG-I– and MDA5-Initiated Innate Immunity Linked With Adaptive Immunity Accelerates β-Cell Death in Fulminant Type 1 Diabetes

    Diabetes March 2011 60:884-889; published ahead of print February 2, 2011, doi:10.2337/db10-0795

Pathophysiology

    • Michael J. Jurczak,
    • Hui-Young Lee,
    • Andreas L. Birkenfeld,
    • Francois R. Jornayvaz,
    • David W. Frederick,
    • Rebecca L. Pongratz,
    • Xiaoxian Zhao,
    • Gilbert W. Moeckel,
    • Varman T. Samuel,
    • Jean M. Whaley,
    • Gerald I. Shulman,
    • and Richard G. Kibbey

    SGLT2 Deletion Improves Glucose Homeostasis and Preserves Pancreatic β-Cell Function

    Diabetes March 2011 60:890-898; doi:10.2337/db10-1328
    • Arti Dhar,
    • Indu Dhar,
    • Bo Jiang,
    • Kaushik M. Desai,
    • and Lingyun Wu

    Chronic Methylglyoxal Infusion by Minipump Causes Pancreatic β-Cell Dysfunction and Induces Type 2 Diabetes in Sprague-Dawley Rats

    Diabetes March 2011 60:899-908; published ahead of print February 7, 2011, doi:10.2337/db10-0627
    • Cheuk-Lun Lee,
    • Philip C.N. Chiu,
    • Poh-Choo Pang,
    • Ivan K. Chu,
    • Kai-Fai Lee,
    • Riitta Koistinen,
    • Hannu Koistinen,
    • Markku Seppälä,
    • Howard R. Morris,
    • Bérangère Tissot,
    • Maria Panico,
    • Anne Dell,
    • and William S.B. Yeung

    Glycosylation Failure Extends to Glycoproteins in Gestational Diabetes Mellitus: Evidence From Reduced α2-6 Sialylation and Impaired Immunomodulatory Activities of Pregnancy-Related Glycodelin-A

    Diabetes March 2011 60:909-917; published ahead of print February 7, 2011, doi:10.2337/db10-1186
    • Changting Xiao,
    • Adria Giacca,
    • and Gary F. Lewis

    Sodium Phenylbutyrate, a Drug With Known Capacity to Reduce Endoplasmic Reticulum Stress, Partially Alleviates Lipid-Induced Insulin Resistance and β-Cell Dysfunction in Humans

    Diabetes March 2011 60:918-924; published ahead of print January 26, 2011, doi:10.2337/db10-1433
    • Isabel Huang-Doran,
    • Louise S. Bicknell,
    • Francis M. Finucane,
    • Nuno Rocha,
    • Keith M. Porter,
    • Y.C. Loraine Tung,
    • Ferenc Szekeres,
    • Anna Krook,
    • John J. Nolan,
    • Mark O’Driscoll,
    • Michael Bober,
    • Stephen O’Rahilly,
    • Andrew P. Jackson,
    • Robert K. Semple,
    • and for the Majewski Osteodysplastic Primordial Dwarfism Study Group

    Genetic Defects in Human Pericentrin Are Associated With Severe Insulin Resistance and Diabetes

    Diabetes March 2011 60:925-935; published ahead of print January 26, 2011, doi:10.2337/db10-1334
    • Reut Ashwal,
    • Rina Hemi,
    • Amir Tirosh,
    • Reut Gordin,
    • Eleanor Yissachar,
    • Anat Cohen-Dayag,
    • Avi Rosenberg,
    • Avraham Karasik,
    • Matthias Blüher,
    • and Hannah Kanety

    Differential Expression of Novel Adiponectin Receptor-1 Transcripts in Skeletal Muscle of Subjects With Normal Glucose Tolerance and Type 2 Diabetes

    Diabetes March 2011 60:936-946; published ahead of print February 2, 2011, doi:10.2337/db09-0532

Complications

    • Chun Hong Shao,
    • Haley L. Capek,
    • Kaushik P. Patel,
    • Mu Wang,
    • Kang Tang,
    • Cyrus DeSouza,
    • Ryoji Nagai,
    • William Mayhan,
    • Muthu Periasamy,
    • and Keshore R. Bidasee

    Carbonylation Contributes to SERCA2a Activity Loss and Diastolic Dysfunction in a Rat Model of Type 1 Diabetes

    Diabetes March 2011 60:947-959; published ahead of print February 7, 2011, doi:10.2337/db10-1145
    • Yuichi Matsushita,
    • Daisuke Ogawa,
    • Jun Wada,
    • Noriko Yamamoto,
    • Kenichi Shikata,
    • Chikage Sato,
    • Hiromi Tachibana,
    • Noriko Toyota,
    • and Hirofumi Makino

    Activation of Peroxisome Proliferator–Activated Receptor δ Inhibits Streptozotocin-Induced Diabetic Nephropathy Through Anti-Inflammatory Mechanisms in Mice

    Diabetes March 2011 60:960-968; published ahead of print January 26, 2011, doi:10.2337/db10-1361
    • Hai-Rong Jin,
    • Woo Jean Kim,
    • Jae Sook Song,
    • Shuguang Piao,
    • Min Ji Choi,
    • Munkhbayar Tumurbaatar,
    • Sun Hwa Shin,
    • Guo Nan Yin,
    • Gou Young Koh,
    • Ji-Kan Ryu,
    • and Jun-Kyu Suh

    Intracavernous Delivery of a Designed Angiopoietin-1 Variant Rescues Erectile Function by Enhancing Endothelial Regeneration in the Streptozotocin-Induced Diabetic Mouse

    Diabetes March 2011 60:969-980; published ahead of print January 26, 2011, doi:10.2337/db10-0354
    • Yumi Takiyama,
    • Tatsuo Harumi,
    • Jun Watanabe,
    • Yukihiro Fujita,
    • Jun Honjo,
    • Norihiko Shimizu,
    • Yuichi Makino,
    • and Masakazu Haneda

    Tubular Injury in a Rat Model of Type 2 Diabetes Is Prevented by Metformin: A Possible Role of HIF-1α Expression and Oxygen Metabolism

    Diabetes March 2011 60:981-992; published ahead of print January 31, 2011, doi:10.2337/db10-0655
    • Hung-Yuan Li,
    • Yi-Der Jiang,
    • Tien-Jyun Chang,
    • Jung-Nan Wei,
    • Mao-Shin Lin,
    • Cheng-Hsin Lin,
    • Fu-Tien Chiang,
    • Shyang-Rong Shih,
    • Chi Sheng Hung,
    • Cyue-Huei Hua,
    • David J. Smith,
    • Jani Vanio,
    • and Lee-Ming Chuang

    Serum Vascular Adhesion Protein-1 Predicts 10-Year Cardiovascular and Cancer Mortality in Individuals With Type 2 Diabetes

    Diabetes March 2011 60:993-999; published ahead of print January 31, 2011, doi:10.2337/db10-0607

Genetics

    • Simonetta Bacci,
    • Stefano Rizza,
    • Sabrina Prudente,
    • Belinda Spoto,
    • Christine Powers,
    • Antonio Facciorusso,
    • Antonio Pacilli,
    • Davide Lauro,
    • Alessandra Testa,
    • Yuan-Yuan Zhang,
    • Giuseppe Di Stolfo,
    • Francesca Mallamaci,
    • Giovanni Tripepi,
    • Rui Xu,
    • Davide Mangiacotti,
    • Filippo Aucella,
    • Renato Lauro,
    • Ernest V. Gervino,
    • Thomas H. Hauser,
    • Massimiliano Copetti,
    • Salvatore De Cosmo,
    • Fabio Pellegrini,
    • Carmine Zoccali,
    • Massimo Federici,
    • Alessandro Doria,
    • and Vincenzo Trischitta

    The ENPP1 Q121 Variant Predicts Major Cardiovascular Events in High-Risk Individuals: Evidence for Interaction With Obesity in Diabetic Patients

    Diabetes March 2011 60:1000-1007; published ahead of print January 31, 2011, doi:10.2337/db10-1300
    • N. Maneka G. De Silva,
    • Rachel M. Freathy,
    • Tom M. Palmer,
    • Louise A. Donnelly,
    • Jian'an Luan,
    • Tom Gaunt,
    • Claudia Langenberg,
    • Michael N. Weedon,
    • Beverley Shields,
    • Beatrice A. Knight,
    • Kirsten J. Ward,
    • Manjinder S. Sandhu,
    • Roger M. Harbord,
    • Mark I. McCarthy,
    • George Davey Smith,
    • Shah Ebrahim,
    • Andrew T. Hattersley,
    • Nicholas Wareham,
    • Debbie A. Lawlor,
    • Andrew D. Morris,
    • Colin N.A. Palmer,
    • and Timothy M. Frayling

    Mendelian Randomization Studies Do Not Support a Role for Raised Circulating Triglyceride Levels Influencing Type 2 Diabetes, Glucose Levels, or Insulin Resistance

    Diabetes March 2011 60:1008-1018; published ahead of print January 31, 2011, doi:10.2337/db10-1317
    • Steven C. Elbein,
    • Philip A. Kern,
    • Neda Rasouli,
    • Aiwei Yao-Borengasser,
    • Neeraj K. Sharma,
    • and Swapan K. Das

    Global Gene Expression Profiles of Subcutaneous Adipose and Muscle From Glucose-Tolerant, Insulin-Sensitive, and Insulin-Resistant Individuals Matched for BMI

    Diabetes March 2011 60:1019-1029; published ahead of print January 24, 2011, doi:10.2337/db10-1270
    • Grant Morahan,
    • Munish Mehta,
    • Ian James,
    • Wei-Min Chen,
    • Beena Akolkar,
    • Henry A. Erlich,
    • Joan E. Hilner,
    • Cécile Julier,
    • Jørn Nerup,
    • Concepcion Nierras,
    • Flemming Pociot,
    • John A. Todd,
    • Stephen S. Rich,
    • and for the Type 1 Diabetes Genetics Consortium

    Tests for Genetic Interactions in Type 1 Diabetes: Linkage and Stratification Analyses of 4,422 Affected Sib-Pairs

    Diabetes March 2011 60:1030-1040; published ahead of print January 24, 2011, doi:10.2337/db10-1195
    • Austin D.-E. Swafford,
    • Joanna M.M. Howson,
    • Lucy J. Davison,
    • Chris Wallace,
    • Deborah J. Smyth,
    • Helen Schuilenburg,
    • Meeta Maisuria-Armer,
    • Trupti Mistry,
    • Michael J. Lenardo,
    • and John A. Todd

    An Allele of IKZF1 (Ikaros) Conferring Susceptibility to Childhood Acute Lymphoblastic Leukemia Protects Against Type 1 Diabetes

    Diabetes March 2011 60:1041-1044; published ahead of print January 26, 2011, doi:10.2337/db10-0446
    • Andrea K. Steck,
    • Taylor K. Armstrong,
    • Sunanda R. Babu,
    • George S. Eisenbarth,
    • and the Type 1 Diabetes Genetics Consortium

    Stepwise or Linear Decrease in Penetrance of Type 1 Diabetes With Lower-Risk HLA Genotypes Over the Past 40 Years

    Diabetes March 2011 60:1045-1049; published ahead of print February 9, 2011, doi:10.2337/db10-1419

Errata

  • Errata

    Diabetes March 2011 60:1050-1051; doi:10.2337/db11-er03

  • Errata

    Diabetes March 2011 60:1052; doi:10.2337/db11-er03a

Issues and Events

  • Issues and Events

    Diabetes March 2011 60:1053; doi:10.2337/db11-ie03
|

This Issue

March 2011; 60 (3)
  1. Editorial
  2. Commentaries
  3. Metabolism
  4. Obesity Studies
  5. Islet Studies
  6. Immunology and Transplantation
  7. Pathophysiology
  8. Complications
  9. Genetics
  10. Errata
  11. Issues and Events

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