Partial Reversibility of Hypothalamic Dysfunction and Changes in Brain Activity After Body Mass Reduction in Obese Subjects

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

FIG. 2.
FIG. 2.

TCA of the human brain after glucose intake. A: Time course of the activation depicted as the means of all analyzed subjects in the respective groups (black, lean; red, obese before surgery; blue, obese after surgery); W1–W3 represent the time windows selected for spatial analysis. B: Spatial mapping of the brain activity at each of the time windows (W1–W3); individual group analyses were performed for lean and obese subjects before and after surgery; comparisons were also performed for all pairs of groups. The inset graphs on the right represent the signal intensity in the region of the hypothalamus for each group. N = 8 for lean subjects; N = 13 for obese subjects. A pixel clustering size of 5 and a t-threshold of |t| >2.1 were chosen to afford a P < 0.01 level of statistical significance of the detected signal changes. This is represented by the different colors, as defined by the normalized color bars. Color bars indicate t value for one-sample t test (lean, BS, and AS) and two-sample t test (lean vs. BS, lean vs. AS, and BS vs. AS). In the insets in B, *P < 0.01 vs. lean and #P < 0.01 vs. before surgery. AS, after surgery; BS, before surgery; Cb, cerebellum; Hy, hypothalamus; Oc, occipital cortex; Of, orbitofrontal cortex; Ss, somatosensory cortex. (A high-quality digital representation of this figure is available in the online issue.)

This Article

  1. Diabetes vol. 60 no. 6 1699-1704