Partial Reversibility of Hypothalamic Dysfunction and Changes in Brain Activity After Body Mass Reduction in Obese Subjects

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FIG. 3.
FIG. 3.

Functional connectivity maps. A seed was placed in the hypothalamus, and intragroup (A–C) and intergroup (D and E) analyses were performed. A: Connectivity maps of lean subjects are depicted. B: Connectivity maps of obese patients before surgery are depicted. C: Connectivity maps of obese patients after surgery are depicted. D: Intergroup analysis between lean subjects and obese patients before surgery (lean × BS) is depicted. E: Intergroup analysis between obese patients before surgery and obese patients after surgery (BS × AS) is depicted. Color bars represent t values. For intragroup analysis (A–C), hot colors indicate the common level of correlation and cold colors indicate the common level of anticorrelation with the time course provided by the seed within each group. For intergroup analysis (D and E), hot colors indicate the level of differences between two groups toward lean and obese patients before surgery, respectively, and cold colors indicate the level of differences between two groups toward obese patients before and after surgery, respectively. AS, after surgery; BS, before surgery; Cb, cerebellum; Hy, hypothalamus; Oc, occipital cortex; Of, orbitofrontal cortex; Ss, somatosensory cortex. (A high-quality digital representation of this figure is available in the online issue.)

This Article

  1. Diabetes vol. 60 no. 6 1699-1704