Partial Reversibility of Hypothalamic Dysfunction and Changes in Brain Activity After Body Mass Reduction in Obese Subjects

TABLE 1

Blood metabolic and inflammatory parameters

Lean Obese before surgery Obese after surgery
6 females, 2 males 11 females, 2 males
Age (years) 29.5 ± 4 34.0 ± 10
BMI (kg/m2) 20.9 ± 2.4 39.1 ± 1.9* 28.1 ± 2.8*§
WC (cm) 72.2 ± 9.2 110.3 ± 9.9* 89.7 ± 8.7*§
HC (cm) 91.3 ± 7.3 127.0 ± 5.2* 105.0 ± 7.5*§
Glucose (mg/dL) 80.6 ± 3.1 84.3 ± 6.1 77.9 ± 7.3
HbA1c (%) 4.8 ± 0.2 5.2 ± 0.3 5.1 ± 0.3
Insulin (pmol/L) 25.0 ± 10.3 68.7 ± 38.1* 21.5 ± 10.4§
HOMA-IR 0.7 ± 0.3 2.1 ± 1.2* 0.6 ± 0.2§
Cholesterol (mg/dL) 189 ± 28 153 ± 24 141 ± 16
HDL (mg/dL) 74.5 ± 25.7 36.9 ± 5.8* 52.6 ± 9.1*§
LDL (mg/dL) 99.5 ± 22.4 97.6 ± 26.4 73.6 ± 16.1
Triglycerides (mg/dL) 75.5 ± 38.9 94.1 ± 27.1 76.6 ± 19.9
CRP (mg/dL) 0.13 ± 0.02 0.91 ± 0.70* 0.17 ± 0.02§
ESR (mm/1 h) 14 ± 12 26 ± 16* 16 ± 9§
Adiponectin (μg/mL) 6.9 ± 1.7 2.7 ± 1.8* 7.8 ± 1.6§
Leptin (ng/mL) 21.4 ± 6.2 36.8 ± 12.0* 17.0 ± 13.9§
TNF-α (pg/mL) 5.8 ± 5.5 25.6 ± 10.3* 12.4 ± 9.8§
IL-1β (pg/mL) 2.0 ± 1.8 42.9 ± 26.7* 13.6 ± 4.3*§
IL-6 (pg/mL) 4.1 ± 4.2 26.3 ± 10.2* 8.5 ± 6.4§
IL-10 (pg/mL) 14.0 ± 10.1 15.6 ± 16.5 15.8 ± 5.5
  • CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; HC, hip circumference; HOMA-IR, homeostasis model assessment of insulin resistance; WC, waist circumference.

  • *P < 0.05 vs. lean.

  • §P < 0.05 vs. obese before surgery.

This Article

  1. Diabetes vol. 60 no. 6 1699-1704