Suppression of FoxO1 Activity by Long-Chain Fatty Acyl Analogs

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FIG. 8.
FIG. 8.

Suppression of FoxO1 by insulin and insulin-mimetics. Suppression of FoxO1 by insulin or Mαα-activated AMPK may be ascribed to its nuclear exclusion and degradation, complemented by suppression of its nuclear transcriptional activity by insulin- or Mαα-induced C/EBPβ isoforms. In contrast with insulin and Mαα, suppression of FoxO1 by metformin is solely accounted for by nuclear exclusion of FoxO1 by metformin-activated AMPK. Suppression of transactivation in the context of FRE-responsive promoters may account for the insulin-sensitizing activity and hypoglycemic hypolipidemic efficacy, whereas suppression of FoxO1 coactivation of STAT3-responsive promoters may account for the insulin-sensitizing activity, anti-inflammatory, and antiatherogenic efficacy of insulin and insulin sensitizers.

This Article

  1. Diabetes vol. 60 no. 7 1872-1881