Table of Contents

Perspectives in Diabetes

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- Norbert Stefan and
- Hans-Ulrich Häring
The Metabolically Benign and Malignant Fatty Liver
Diabetes August 2011 60:2011-2017; doi:10.2337/db11-0231

Commentaries

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- Gordon C. Weir and
- Susan Bonner-Weir
Sleeping Islets and the Relationship Between β-Cell Mass and Function
Diabetes August 2011 60:2018-2019; doi:10.2337/db10-1808
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- Roberto Mallone and
- Vedran Brezar
To B or Not to B: (Anti)bodies of Evidence on the Crime Scene of Type 1 Diabetes?
Diabetes August 2011 60:2020-2022; doi:10.2337/db11-0700

Metabolism

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- Nirupa Sachithanandan,
- Kate L. Graham,
- Sandra Galic,
- Jane E. Honeyman,
- Stacey L. Fynch,
- Kimberly A. Hewitt,
- Gregory R. Steinberg,
- and Thomas W. Kay
Macrophage Deletion of SOCS1 Increases Sensitivity to LPS and Palmitic Acid and Results in Systemic Inflammation and Hepatic Insulin Resistance
Diabetes August 2011 60:2023-2031; published ahead of print June 6, 2011, doi:10.2337/db11-0259
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- Christina Koutsari,
- Asem H. Ali,
- Manpreet S. Mundi,
- and Michael D. Jensen
Storage of Circulating Free Fatty Acid in Adipose Tissue of Postabsorptive Humans: Quantitative Measures and Implications for Body Fat Distribution
Diabetes August 2011 60:2032-2040; published ahead of print June 9, 2011, doi:10.2337/db11-0154
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- Ying Wang,
- Prasanth Puthanveetil,
- Fang Wang,
- Min Suk Kim,
- Ashraf Abrahani,
- and Brian Rodrigues
Severity of Diabetes Governs Vascular Lipoprotein Lipase by Affecting Enzyme Dimerization and Disassembly
Diabetes August 2011 60:2041-2050; published ahead of print June 6, 2011, doi:10.2337/db11-0042
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- Sangeeta Ghosh,
- Raweewan Lertwattanarak,
- Natalie Lefort,
- Marjorie Molina-Carrion,
- Joaquin Joya-Galeana,
- Benjamin P. Bowen,
- Jose de Jesus Garduno-Garcia,
- Muhammad Abdul-Ghani,
- Arlan Richardson,
- Ralph A. DeFronzo,
- Lawrence Mandarino,
- Holly Van Remmen,
- and Nicolas Musi
Reduction in Reactive Oxygen Species Production by Mitochondria From Elderly Subjects With Normal and Impaired Glucose Tolerance
Diabetes August 2011 60:2051-2060; published ahead of print June 15, 2011, doi:10.2337/db11-0121
Select this article
- Alexey Shemyakin,
- Firoozeh Salehzadeh,
- Daniella Esteves Duque-Guimaraes,
- Felix Böhm,
- Eric Rullman,
- Thomas Gustafsson,
- John Pernow,
- and Anna Krook
Endothelin-1 Reduces Glucose Uptake in Human Skeletal Muscle In Vivo and In Vitro
Diabetes August 2011 60:2061-2067; published ahead of print June 15, 2011, doi:10.2337/db10-1281
Select this article
- Richard Olsson and
- Per-Ola Carlsson
A Low-Oxygenated Subpopulation of Pancreatic Islets Constitutes a Functional Reserve of Endocrine Cells
Diabetes August 2011 60:2068-2075; doi:10.2337/db09-0877

Islet Studies

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- Evrard Nguidjoe,
- Sophie Sokolow,
- Serge Bigabwa,
- Nathalie Pachera,
- Eva D'Amico,
- Florent Allagnat,
- Jean-Marie Vanderwinden,
- Abdullah Sener,
- Mario Manto,
- Marianne Depreter,
- Jan Mast,
- Geraldine Joanny,
- Eduard Montanya,
- Jacques Rahier,
- Alessandra K. Cardozo,
- Décio L. Eizirik,
- Stéphane Schurmans,
- and André Herchuelz
Heterozygous Inactivation of the Na/Ca Exchanger Increases Glucose-Induced Insulin Release, β-Cell Proliferation, and Mass
Diabetes August 2011 60:2076-2085; published ahead of print June 9, 2011, doi:10.2337/db10-0924
Select this article
- Diego Ize-Ludlow,
- Yaima L. Lightfoot,
- Matthew Parker,
- Song Xue,
- Clive Wasserfall,
- Michael J. Haller,
- Desmond Schatz,
- Dorothy J. Becker,
- Mark A. Atkinson,
- and Clayton E. Mathews
Progressive Erosion of β-Cell Function Precedes the Onset of Hyperglycemia in the NOD Mouse Model of Type 1 Diabetes
Diabetes August 2011 60:2086-2091; published ahead of print June 9, 2011, doi:10.2337/db11-0373
Select this article
- Israel Hodish,
- Afaf Absood,
- Leanza Liu,
- Ming Liu,
- Leena Haataja,
- Dennis Larkin,
- Ahmed Al-Khafaji,
- Anthony Zaki,
- and Peter Arvan
In Vivo Misfolding of Proinsulin Below the Threshold of Frank Diabetes
Diabetes August 2011 60:2092-2101; published ahead of print June 15, 2011, doi:10.2337/db10-1671

Immunology and Transplantation

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- Diego G. Silva,
- Stephen R. Daley,
- Jennifer Hogan,
- Sau K. Lee,
- Charis E. Teh,
- Daniel Y. Hu,
- Kong-Peng Lam,
- Christopher C. Goodnow,
- and Carola G. Vinuesa
Anti-Islet Autoantibodies Trigger Autoimmune Diabetes in the Presence of an Increased Frequency of Islet-Reactive CD4 T Cells
Diabetes August 2011 60:2102-2111; doi:10.2337/db10-1344
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- Sefina Arif,
- Fabrice Moore,
- Katherine Marks,
- Thomas Bouckenooghe,
- Colin M. Dayan,
- Raquel Planas,
- Marta Vives-Pi,
- Jake Powrie,
- Timothy Tree,
- Piero Marchetti,
- Guo Cai Huang,
- Esteban N. Gurzov,
- Ricardo Pujol-Borrell,
- Decio L. Eizirik,
- and Mark Peakman
Peripheral and Islet Interleukin-17 Pathway Activation Characterizes Human Autoimmune Diabetes and Promotes Cytokine-Mediated β-Cell Death
Diabetes August 2011 60:2112-2119; published ahead of print June 9, 2011, doi:10.2337/db10-1643
Select this article
- Ester Badami,
- Chiara Sorini,
- Margherita Coccia,
- Vera Usuelli,
- Laura Molteni,
- Andrea Mario Bolla,
- Marina Scavini,
- Alberto Mariani,
- Cecile King,
- Emanuele Bosi,
- and Marika Falcone
Defective Differentiation of Regulatory FoxP3⁺ T Cells by Small-Intestinal Dendritic Cells in Patients With Type 1 Diabetes
Diabetes August 2011 60:2120-2124; published ahead of print June 6, 2011, doi:10.2337/db10-1201
Select this article
- Angela Hughson,
- Irina Bromberg,
- Barbara Johnson,
- Sally Quataert,
- Nicholas Jospe,
- and Deborah J. Fowell
Uncoupling of Proliferation and Cytokines From Suppression Within the CD4+CD25+Foxp3+ T–Cell Compartment in the 1st Year of Human Type 1 Diabetes
Diabetes August 2011 60:2125-2133; published ahead of print June 29, 2011, doi:10.2337/db10-1661
Select this article
- Daorong Feng,
- Yan Tang,
- Hyokjoon Kwon,
- Haihong Zong,
- Meredith Hawkins,
- Richard N. Kitsis,
- and Jeffrey E. Pessin
High-Fat Diet–Induced Adipocyte Cell Death Occurs Through a Cyclophilin D Intrinsic Signaling Pathway Independent of Adipose Tissue Inflammation
Diabetes August 2011 60:2134-2143; published ahead of print July 6, 2011, doi:10.2337/db10-1411
Select this article
- Terri C. Thayer,
- Matthew Delano,
- Chao Liu,
- Jing Chen,
- Lindsey E. Padgett,
- Hubert M. Tse,
- Mani Annamali,
- Jon D. Piganelli,
- Lyle L. Moldawer,
- and Clayton E. Mathews
Superoxide Production by Macrophages and T Cells Is Critical for the Induction of Autoreactivity and Type 1 Diabetes
Diabetes August 2011 60:2144-2151; published ahead of print June 29, 2011, doi:10.2337/db10-1222

Pathophysiology

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- Nolwenn Regnault,
- Jérémie Botton,
- Barbara Heude,
- Anne Forhan,
- Régis Hankard,
- Bernard Foliguet,
- Teresa A. Hillier,
- Jean-Claude Souberbielle,
- Patricia Dargent-Molina,
- Marie-Aline Charles,
- and the EDEN Mother-Child Cohort Study Group
Higher Cord C-Peptide Concentrations Are Associated With Slower Growth Rate in the 1st Year of Life in Girls but Not in Boys
Diabetes August 2011 60:2152-2159; published ahead of print June 23, 2011, doi:10.2337/db10-1189
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- Björn A. Menge,
- Lena Grüber,
- Signe M. Jørgensen,
- Carolyn F. Deacon,
- Wolfgang E. Schmidt,
- Johannes D. Veldhuis,
- Jens J. Holst,
- and Juris J. Meier
Loss of Inverse Relationship Between Pulsatile Insulin and Glucagon Secretion in Patients With Type 2 Diabetes
Diabetes August 2011 60:2160-2168; published ahead of print June 15, 2011, doi:10.2337/db11-0251
Select this article
- Afroze Abbas,
- Helen Imrie,
- Hema Viswambharan,
- Piruthivi Sukumar,
- Adil Rajwani,
- Richard M. Cubbon,
- Matthew Gage,
- Jessica Smith,
- Stacey Galloway,
- Nadira Yuldeshava,
- Matthew Kahn,
- Shouhong Xuan,
- Peter J. Grant,
- Keith M. Channon,
- David J. Beech,
- Stephen B. Wheatcroft,
- and Mark T. Kearney
The Insulin-Like Growth Factor-1 Receptor Is a Negative Regulator of Nitric Oxide Bioavailability and Insulin Sensitivity in the Endothelium
Diabetes August 2011 60:2169-2178; published ahead of print June 15, 2011, doi:10.2337/db11-0197
Select this article
- José Manuel Fernández-Real,
- Sofia Pérez del Pulgar,
- Elodie Luche,
- José Maria Moreno-Navarrete,
- Aurelie Waget,
- Matteo Serino,
- Eleonora Sorianello,
- Alex Sánchez-Pla,
- Francesc Carmona Pontaque,
- Joan Vendrell,
- Matilde R. Chacón,
- Wifredo Ricart,
- Remy Burcelin,
- and Antonio Zorzano
CD14 Modulates Inflammation-Driven Insulin Resistance
Diabetes August 2011 60:2179-2186; published ahead of print June 23, 2011, doi:10.2337/db10-1210

Complications

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- Agbor Ndip,
- Alfred Williams,
- Edward B. Jude,
- Ferdinand Serracino-Inglott,
- Steve Richardson,
- J.V. Smyth,
- Andrew J.M. Boulton,
- and M. Yvonne Alexander
The RANKL/RANK/OPG Signaling Pathway Mediates Medial Arterial Calcification in Diabetic Charcot Neuroarthropathy
Diabetes August 2011 60:2187-2196; published ahead of print June 9, 2011, doi:10.2337/db10-1220

Genetics

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- Lu Qi,
- Claudia Menzaghi,
- Lucia Salvemini,
- Concetta De Bonis,
- Vincenzo Trischitta,
- and Frank B. Hu
Novel Locus FER Is Associated With Serum HMW Adiponectin Levels
Diabetes August 2011 60:2197-2201; published ahead of print June 23, 2011, doi:10.2337/db10-1645

Issues and Events

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Issues and Events
Diabetes August 2011 60:2202; doi:10.2337/db11-ie08

Online Letters to the Editor

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- Dimitrios Tsikas,
- Stefan Engeli,
- Jens Tank,
- Dirk O. Stichtenoth,
- and Jens Jordan
Comment on: Ott et al. Reduction in Basal Nitric Oxide Activity Causes Albuminuria. Diabetes 2011;60:572–576
Diabetes August 2011 60:e21; doi:10.2337/db11-0519
Select this article
- Christian Ott,
- Markus P. Schneider,
- and Roland E. Schmieder
Response to Comment on: Ott et al. Reduction in Basal Nitric Oxide Activity Causes Albuminuria. Diabetes 2011;60:572–576
Diabetes August 2011 60:e22; doi:10.2337/db11-0602

Diabetes

Perspectives in Diabetes

The Metabolically Benign and Malignant Fatty Liver

Commentaries

Sleeping Islets and the Relationship Between β-Cell Mass and Function

To B or Not to B: (Anti)bodies of Evidence on the Crime Scene of Type 1 Diabetes?

Metabolism

Macrophage Deletion of SOCS1 Increases Sensitivity to LPS and Palmitic Acid and Results in Systemic Inflammation and Hepatic Insulin Resistance

Storage of Circulating Free Fatty Acid in Adipose Tissue of Postabsorptive Humans: Quantitative Measures and Implications for Body Fat Distribution

Severity of Diabetes Governs Vascular Lipoprotein Lipase by Affecting Enzyme Dimerization and Disassembly

Reduction in Reactive Oxygen Species Production by Mitochondria From Elderly Subjects With Normal and Impaired Glucose Tolerance

Endothelin-1 Reduces Glucose Uptake in Human Skeletal Muscle In Vivo and In Vitro

A Low-Oxygenated Subpopulation of Pancreatic Islets Constitutes a Functional Reserve of Endocrine Cells

Islet Studies

Heterozygous Inactivation of the Na/Ca Exchanger Increases Glucose-Induced Insulin Release, β-Cell Proliferation, and Mass

Progressive Erosion of β-Cell Function Precedes the Onset of Hyperglycemia in the NOD Mouse Model of Type 1 Diabetes

In Vivo Misfolding of Proinsulin Below the Threshold of Frank Diabetes

Immunology and Transplantation

Anti-Islet Autoantibodies Trigger Autoimmune Diabetes in the Presence of an Increased Frequency of Islet-Reactive CD4 T Cells

Peripheral and Islet Interleukin-17 Pathway Activation Characterizes Human Autoimmune Diabetes and Promotes Cytokine-Mediated β-Cell Death

Defective Differentiation of Regulatory FoxP3+ T Cells by Small-Intestinal Dendritic Cells in Patients With Type 1 Diabetes

Uncoupling of Proliferation and Cytokines From Suppression Within the CD4+CD25+Foxp3+ T–Cell Compartment in the 1st Year of Human Type 1 Diabetes

High-Fat Diet–Induced Adipocyte Cell Death Occurs Through a Cyclophilin D Intrinsic Signaling Pathway Independent of Adipose Tissue Inflammation

Superoxide Production by Macrophages and T Cells Is Critical for the Induction of Autoreactivity and Type 1 Diabetes

Pathophysiology

Higher Cord C-Peptide Concentrations Are Associated With Slower Growth Rate in the 1st Year of Life in Girls but Not in Boys

Loss of Inverse Relationship Between Pulsatile Insulin and Glucagon Secretion in Patients With Type 2 Diabetes

The Insulin-Like Growth Factor-1 Receptor Is a Negative Regulator of Nitric Oxide Bioavailability and Insulin Sensitivity in the Endothelium

CD14 Modulates Inflammation-Driven Insulin Resistance

Complications

The RANKL/RANK/OPG Signaling Pathway Mediates Medial Arterial Calcification in Diabetic Charcot Neuroarthropathy

Genetics

Novel Locus FER Is Associated With Serum HMW Adiponectin Levels

Issues and Events

Issues and Events

Online Letters to the Editor

Comment on: Ott et al. Reduction in Basal Nitric Oxide Activity Causes Albuminuria. Diabetes 2011;60:572–576

Response to Comment on: Ott et al. Reduction in Basal Nitric Oxide Activity Causes Albuminuria. Diabetes 2011;60:572–576

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Defective Differentiation of Regulatory FoxP3⁺ T Cells by Small-Intestinal Dendritic Cells in Patients With Type 1 Diabetes