Maternal Serum Levels of 25-Hydroxy-Vitamin D During Pregnancy and Risk of Type 1 Diabetes in the Offspring
- Ingvild M. Sørensen1⇓,
- Geir Joner1,2,
- Pål A. Jenum3,
- Anne Eskild4,5,
- Peter A. Torjesen6 and
- Lars C. Stene7
- 1Department of Pediatrics, Oslo University Hospital Ullevål, Oslo, Norway
- 2Department of Health Management and Health Economics, Institute of Health and Society, University of Oslo, Oslo, Norway
- 3Department of Medical Microbiology, Vestre Viken Hospital Trust, Rud, Norway
- 4Department of Obstetrics and Gynecology, Akershus University Hospital, Oslo, Norway
- 5Institute of Clinical Medicine, University of Oslo, Oslo, Norway
- 6Hormone Laboratory, Oslo University Hospital Aker, Oslo, Norway
- 7Norwegian Institute of Public Health, Oslo, Norway
- Corresponding author: Ingvild M. Sørensen, .
Previous studies indicate reduced risk of type 1 diabetes after intake of vitamin D supplements during pregnancy or early childhood. We aimed to test whether lower maternal serum concentrations of 25-hydroxy-vitamin D (25-OH D) during pregnancy were associated with an increased risk of childhood-onset type 1 diabetes. In this case-control study nested within a cohort of 29,072 women in Norway, 25-OH D levels were measured using a radioimmunoassay on samples from late pregnancy in 109 women delivering a child who developed type 1 diabetes before 15 years of age (case subjects) and from 219 control women. Dividing the levels of maternal 25-OH D into quartiles, there was a trend toward a higher risk of type 1 diabetes with lower levels of vitamin D during pregnancy. The odds of type 1 diabetes was more than twofold higher for the offspring of women with the lowest levels of 25-OH D compared with the offspring of those with levels above the upper quartile. Given future replication in independent cohorts, our findings provide support for the initiation of a randomized intervention trial to prevent type 1 diabetes in children by enhancing maternal 25-OH D status during pregnancy.
This article contains Supplementary Data online at http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db11-0875/-/DC1.
- Received June 24, 2011.
- Accepted October 5, 2011.
- © 2012 by the American Diabetes Association.
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