Insulin Sensitivity and β-Cell Function in Adults Born Preterm and Their Children
- Sarah Mathai1,2,
- Wayne S. Cutfield1,2,
- José G.B. Derraik1,
- Stuart R. Dalziel3,
- Jane E. Harding1,
- Elizabeth Robinson4,
- Janene Biggs1,
- Craig Jefferies1 and
- Paul L. Hofman1,2⇓
- 1Liggins Institute, University of Auckland, Auckland, New Zealand
- 2National Research Centre for Growth and Development, University of Auckland, Auckland, New Zealand
- 3Children’s Emergency Department, Starship Children’s Hospital, Auckland, New Zealand
- 4Department of Epidemiology and Biostatistics, University of Auckland, Auckland, New Zealand
- Corresponding author: Paul L. Hofman, .
We aimed to evaluate insulin secretion and insulin sensitivity in adults born preterm and their children. Subjects were adults born both preterm and at term, with their children aged 5–10 years born at term. Insulin sensitivity and secretion were assessed using hyperglycemic clamps in adults and frequently sampled intravenous glucose tolerance tests using Bergman minimal model in children. In total, 52 adults aged 34–38 years participated (31 born preterm, mean gestational age 33.3 weeks). Adults born preterm were less insulin sensitive than those born at term (19.0 ± 2.5 vs. 36.3 ± 5.2 mg ⋅ kg−1 ⋅ min−1mU ⋅ L; P < 0.05) with compensatory increased first-phase insulin secretion (56.1 ± 8.5 vs. 25.3 ± 3.7 mU/L; P < 0.001) but similar disposition index indicating appropriate insulin secretion. These differences were independent of sex and remained when subjects born <32 weeks' gestation were excluded from analyses. In total, 61 children were studied (37 of preterm parents, mean age 7.9 ± 0.3 years). Children of parents born preterm had similar insulin sensitivity to children of parents born at term, but a correlation between parental and offspring insulin sensitivity was noted only among children of parents born preterm. In conclusion, adults born preterm have insulin resistance in midadulthood, but this was not associated with insulin resistance in their children.
- Received December 1, 2011.
- Accepted March 28, 2012.
- © 2012 by the American Diabetes Association.
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