31P-Magnetization Transfer Magnetic Resonance Spectroscopy Measurements of In Vivo Metabolism
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Both Pi → ATP flux, assessed by 31P-ST MRS, and TCA cycle flux, measured using 13C-MRS to monitor the metabolism of infused [2-13C]acetate, were reduced by ∼40% in the muscle of healthy elderly subjects. Data adapted from Petersen et al. (18), reproduced courtesy of Science.