Pi → ATP flux was reduced by ∼30% in healthy, young, lean IR offspring of type 2 diabetic patients (IR offspring) compared with
age-BMI-activity–matched IS control subjects (IS subjects). A similar decrease in TCA cycle flux was observed in an equivalent
group of IR offspring. Adapted from Petersen et al. (19) and reproduced courtesy of the New England Journal of Medicine. Data reproduced from Befroy et al. (20).