C1q/TNF-Related Protein-3 (CTRP-3) and Pigment Epithelium-Derived Factor (PEDF) Concentrations in Patients With Type 2 Diabetes and Metabolic Syndrome
- Kyung Mook Choi1,
- Soon Young Hwang2,
- Ho Cheol Hong1,
- Sae Jeong Yang1,
- Hae Yoon Choi1,
- Hye Jin Yoo1,
- Kwan Woo Lee3,
- Moon Suk Nam4,
- Yong Soo Park5,
- Jeong Taek Woo6,
- Young Seol Kim6,
- Dong Seop Choi1,
- Byung-Soo Youn7 and
- Sei Hyun Baik1⇓
- 1Department of Internal Medicine, Division of Endocrinology and Metabolism, College of Medicine, Korea University, Seoul, Korea
- 2Department of Biostatistics, College of Medicine, Korea University, Seoul, Korea
- 3Department of Internal Medicine, College of Medicine, Ajou University, Suwon, Korea
- 4Department of Internal Medicine, College of Medicine, Inha University, Incheon, Korea
- 5Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, Korea
- 6Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Korea
- 7AdipoGen, Inc., Yeonsu-gu, Incheon, Korea
- Corresponding author: Sei Hyun Baik, .
B.-S.Y. and S.H.B. contributed equally to this work.
Recent studies have suggested that a novel adipokine, C1q/tumor necrosis factor-related protein-3 (CTRP-3), a paralog of adiponectin, may play an important role in the regulation of glucose metabolism and innate immunity. Pigment epithelium-derived factor (PEDF), a multifunctional protein with antioxidant and anti-inflammatory properties, is associated with insulin resistance and metabolic syndrome. We examined circulating CTRP-3 and PEDF concentrations in 345 subjects with diverse glucose tolerance statuses. Furthermore, we evaluated the involvement of CTRP-3 and PEDF with cardiometabolic risk factors including insulin resistance, high-sensitivity C-reactive protein (hsCRP), estimated glomerular filtration rate (eGFR), and brachial-ankle pulse wave velocity (baPWV). CTRP-3 concentrations were significantly higher in patients with type 2 diabetes or prediabetes than the normal glucose tolerance group, whereas PEDF levels were not different. Subjects with metabolic syndrome showed significantly higher levels of both CTRP-3 and PEDF compared with subjects without metabolic syndrome. Both CTRP-3 and PEDF were significantly associated with cardiometabolic parameters, including waist-to-hip ratio, triglycerides, HDL-cholesterol, alanine aminotransferase, eGFR, hsCRP, and baPWV. In conclusion, circulating CTRP-3 concentrations were elevated in patients with glucose metabolism dysregulation. Both CTRP-3 and PEDF concentrations were increased in subjects with metabolic syndrome and associated with various cardiometabolic risk factors.
This article contains Supplementary Data online at http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db12-0217/-/DC1.
- Received February 28, 2012.
- Accepted May 7, 2012.
- © 2012 by the American Diabetes Association.
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