Schematic overview of the instant blood-mediated inflammatory response. Tissue factor expression and antibody binding to non-Gal
antigens (as well as to Gal on neonatal pig islets) activate coagulation and complement cascades, leading to clotting, direct
cellular membrane damage through the membrane attack complex (MAC), and recruitment of macrophages and monocytes through the
chemoattractants C3a and C5a. TF, tissue factor.