Clinical Islet Xenotransplantation

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FIG. 1.
FIG. 1.

Schematic overview of the instant blood-mediated inflammatory response. Tissue factor expression and antibody binding to non-Gal antigens (as well as to Gal on neonatal pig islets) activate coagulation and complement cascades, leading to clotting, direct cellular membrane damage through the membrane attack complex (MAC), and recruitment of macrophages and monocytes through the chemoattractants C3a and C5a. TF, tissue factor.

This Article

  1. Diabetes vol. 61 no. 12 3046-3055