Clinical Islet Xenotransplantation

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FIG. 3.
FIG. 3.

A: Functional survival of pig islets with a single genetic modification, that is, the transgenic expression of a human complement regulatory protein (hCD46), after transplantation in a cohort of five diabetic cynomolgus monkey recipients. Immunosuppression consisted of induction with antithymocyte globulin and was maintained with an anti-CD154 mAb and mycophenolate mofetil. All experiments were electively terminated; all monkeys were healthy when they were killed. Partial graft function (white bars) and full graft function (insulin independence) (black bars) are shown. Arrowheads indicate retransplantation. B: Serum acute C-peptide responses (ACR) of monkey C-peptide (white bars) and pig C-peptide (black bars) in nanograms per milliliter after a metabolic challenge with intravenous glucose (glu) during follow-up of case 5. The ACR was calculated as the mean of postchallenge C-peptide values obtained at 5 and 15 min minus the corresponding prechallenge value. Pre, the acute monkey C-peptide response before diabetes induction; post, the average of acute monkey C-peptide responses during follow-up after transplantation, monitored until day 372. C: Blood glucose values and insulin requirements in a monkey transplanted with pig islets carrying four genetic modifications—GTKO/hCD46/hTFPIIns/pCTLA4-IgIns. The monkey is currently insulin independent for >150 days. Immunosuppression is identical to the regimen in A.

This Article

  1. Diabetes vol. 61 no. 12 3046-3055