Response to Comment on: Greenbaum et al. Through the Fog: Recent Clinical Trials to Preserve β-Cell Function in Type 1 Diabetes. Diabetes 2012;61:1323–1330

  1. Srinath Sanda1,3
  1. From the 1Benaroya Research Institute, Seattle, Washington; the
  2. 2Department of Pediatrics, Division of Endocrinology, University of Florida, Gainesville, Florida; and the
  3. 3Department of Pediatrics, Division of Endocrinology, Seattle Children’s Hospital, Seattle, Washington
  1. Corresponding author: Carla J. Greenbaum, cjgreen{at}

We applaud the thoughtful letter from Vialettes and Valéro (1) bringing attention to endoplasmic reticulum (ER) stress as a potential mechanism influencing the decline in β-cell function observed in individuals with type 1 diabetes. We agree that it is a plausible mechanism underlying the preservation of C-peptide seen with aggressive correction of metabolic dysregulation and look forward …

| Table of Contents